Some properties of two Nambu--Jona-Lasinio -type models with inputs from lattice QCD

We investigate the phase diagram of the so-called Polyakov--Nambu--Jona-Lasinio (PNJL) model at finite temperature and nonzero chemical potential. The calculations are performed in the light and strange quark sectors ($u$, $d$, $s$), which includes the 't Hooft instanton induced interaction term that breaks the axial symmetry, and the quarks are coupled to the (spatially constant) temporal background gauge field. On one hand, a special attention is payed to the critical end point (CEP). The strength of the flavor-mixing interaction alters the CEP location, since when it becomes weaker the CEP moves to low temperatures and can even disappear. On the other hand, we also explore the connection between QCD, a nonlocal Nambu--Jona-Lasinio type model and the Landau gauge gluon propagator. Possible links between the quenched gluon propagator and low energy hadronic phenomenology are investigated.Comment: Contribution to the International Meeting "Excited QCD", Peniche, Portugal, 06 - 12 May 201

Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury

AIMS: Neuropilins 1 and 2 (NRP1 and NRP2) play crucial roles in endothelial cell migration contributing to angiogenesis and vascular development. Both NRPs are also expressed by cultured vascular smooth muscle cells (VSMCs) and are implicated in VSMC migration stimulated by PDGF-BB, but it is unknown whether NRPs are relevant for VSMC function in vivo. We investigated the role of NRPs in the rat carotid balloon injury model, in which endothelial denudation and arterial stretch induce neointimal hyperplasia involving VSMC migration and proliferation. METHODS AND RESULTS: NRP1 and NRP2 mRNAs and proteins increased significantly following arterial injury, and immunofluorescent staining revealed neointimal NRP expression. Down-regulation of NRP1 and NRP2 using shRNA significantly reduced neointimal hyperplasia following injury. Furthermore, inhibition of NRP1 by adenovirally overexpressing a loss-of-function NRP1 mutant lacking the cytoplasmic domain (ΔC) reduced neointimal hyperplasia, whereas wild-type (WT) NRP1 had no effect. NRP-targeted shRNAs impaired, while overexpression of NRP1 WT and NRP1 ΔC enhanced, arterial re-endothelialization 14 days after injury. Knockdown of either NRP1 or NRP2 inhibited PDGF-BB-induced rat VSMC migration, whereas knockdown of NRP2, but not NRP1, reduced proliferation of cultured rat VSMC and neointimal VSMC in vivo. NRP knockdown also reduced the phosphorylation of PDGFα and PDGFβ receptors in rat VSMC, which mediate VSMC migration and proliferation. CONCLUSION: NRP1 and NRP2 play important roles in the regulation of neointimal hyperplasia in vivo by modulating VSMC migration (via NRP1 and NRP2) and proliferation (via NRP2), independently of the role of NRPs in re-endothelialization

Non-maximal sensitivity to synchronism in periodic elementary cellular automata: exact asymptotic measures

In [11] and [13] the authors showed that elementary cellular automata rules 0, 3, 8, 12, 15, 28, 32, 34, 44, 51, 60, 128, 136, 140, 160, 162, 170, 200 and 204 (and their conjugation, reflection, reflected-conjugation) are not maximum sensitive to synchronism, i.e. they do not have a different dynamics for each (non-equivalent) block-sequential update schedule (defined as ordered partitions of cell positions). In this work we present exact measurements of the sensitivity to synchronism for these rules, as functions of the size. These exhibit a surprising variety of values and associated proof methods, such as the special pairs of rule 128, and the connection to the bissection of Lucas numbers of rule 8

Incumbents, opposition and international lenders: governing Portugal in times of crisis

The Portuguese case provides a unique opportunity to study the opposition's behaviour in a variety of political conditions. It offers an insight into the impact of the financial crisis on the opposition's behaviour in both majority and minority political settings. It allows the comparison of the opposition's relationship with a minority government, during which non-collaboration could have dramatic consequences, and also with a majority government, when such a choice does not have major political or policy implications. Moreover, it enables us to study the effect of an additional veto player (the so-called troika composed of the European Commission, the European Central Bank and the International Monetary Fund), which not only constrains both majority and opposition parties, but also gives political entrepreneurs a unique opportunity to push ahead with liberal measures \u2013 in this case, clearly in disagreement with the moderate and radical left programmes. Relying on quantitative data on the legislative behaviour of the parliamentary party groups in the period 1995\u20132012, and on qualitative process-tracking of the opposition's positions on key economic issues \u2013 such as the decision to vote against Prime Minister S\uf3crates' last austerity package after a series of approvals \u2013 this article aims to determine whether, and if yes how, the financial crisis has affected the behaviour of the Portuguese opposition parties in parliament, by examining and comparing their behaviour in hard and in normal times

Effective restoration of chiral and axial symmetries at finite temperature and density

The effective restoration of chiral and axial symmetries is investigated within the framework of the SU(3) Nambu-Jona-Lasinio model. The topological susceptibility, modeled from lattice data at finite temperature, is used to extract the temperature dependence of the coupling strength of the anomaly. The study of the scalar and pseudoscalar mixing angles is performed in order to discuss the evolution of the flavor combinations of $q \bar q$ pairs and its consequences for the degeneracy of chiral partners. A similar study at zero temperature and finite density is also realized.Comment: 5 pages, 1 figure. Talk given at Strange Quark Matter 2004, Cape Town, South Africa, 15-20 September, 200

Efficacy of pimobendan in the prevention of congestive heart failure or sudden death in doberman pinschers with preclinical dilated cardiomyopathy (the PROTECT study)

<p>Background: The benefit of pimobendan in delaying the progression of preclinical dilated cardiomyopathy (DCM) in Dobermans is not reported.</p> <p>Hypothesis: That chronic oral administration of pimobendan to Dobermans with preclinical DCM will delay the onset of CHF or sudden death and improve survival.</p> <p>Animals: Seventy-six client-owned Dobermans recruited at 10 centers in the UK and North America.</p> <p>Methods: The trial was a randomized, blinded, placebo-controlled, parallel group multicenter study. Dogs were allocated in a 1:1 ratio to receive pimobendan (Vetmedin capsules) or visually identical placebo.</p> <p>The composite primary endpoint was prospectively defined as either onset of CHF or sudden death. Time to death from all causes was a secondary endpoint.</p> <p>Results: The proportion of dogs reaching the primary endpoint was not significantly different between groups (P = .1). The median time to the primary endpoint (onset of CHF or sudden death) was significantly longer in the pimobendan (718 days, IQR 441–1152 days) versus the placebo group (441 days, IQR 151–641 days) (log-rank P = 0.0088). The median survival time was significantly longer in the pimobendan (623 days, IQR 491–1531 days) versus the placebo group (466 days, IQR 236–710 days) (log-rank P = .034).</p> <p>Conclusion and Clinical Importance: The administration of pimobendan to Dobermans with preclinical DCM prolongs the time to the onset of clinical signs and extends survival. Treatment of dogs in the preclinical phase of this common cardiovascular disorder with pimobendan can lead to improved outcome.</p&gt

Usefulness of Perfusion CT to Assess Response to Neoadjuvant Combined Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer

RATIONALE AND OBJECTIVES: To prospectively evaluate perfusion computed tomography (CT) for assessment of changes in tumor vascularity after chemoradiation therapy (CRT) in locally advanced rectal cancer and to analyze the correlation between baseline perfusion parameters and tumor response. MATERIALS AND METHODS: Twenty patients with rectal cancer underwent baseline perfusion CT before CRT, and in 11 an examination after CRT was also performed. For each tumor, blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability-surface area product (PS) were quantified. The Mann-Whitney U test compared baseline perfusion parameters of responders and nonresponders and pre- and post-CRT measurements were compared by the Wilcoxon signed-rank test (P < .05 statistically significant for both tests). RESULTS: Baseline BF was significantly lower (P = .013) and MTT was significantly higher (P = .006) in responders. Both were able to discriminate responders from nonresponders with a sensitivity of 80% and 100% and a specificity of 73.3% and 86.7%, respectively, for BF and MTT. Baseline BV and PS were not significantly different in responders and nonresponders. Perfusion parameters changed significantly in post-CRT scans compared to baseline: BF (P = .003), BV (P = .003), and PS (P = .008) decreased, whereas MTT increased (P = .006). CONCLUSION: Baseline BF and MTT can discriminate patients with a favorable response from those that fail to respond to CRT, potentially selecting high-risk patients with resistant tumors that may benefit from an aggressive preoperative treatment approach

Características de la canal de terneros de la Denominación de Origen Protegida Mirandesa

El objetivo de este trabajo fue evaluar las características de la canal de la raza Mirandesa. Para llevar a cabo este estudio, un total de 20 animales de la raza Mirandesa fueron sacrificados a los 315 días. 24 horas tras el sacrificio, se determinó el peso canal y rendimiento canal, se realizaron las medidas morfométricas (longitud de la canal, longitud de la pierna, espesor de la pierna, profundidad interna del pecho y perímetro máximo de la pierna), se calcularon los siguientes índices: índice de compacidad de la canal e índice longitudinal transversal de la pierna y se realizó el despiece de los principales cortes comerciales. Los animales de la raza Mirandesa presentaron un peso vivo de 293,7 kg, un peso canal de 152 kg y un rendimiento canal de 60,5 %. En relación a las medidas morfométricas, la raza Mirandesa mostró una longitud de canal de 110 cm, una longitud de pierna de 69 cm y un perímetro de pierna de 89,8 cm. Los valores para el índice de compacidad de la canal y el índice longitudinal transversal de la pierna fueron de 1,4 y 3,7, respectivamente. Con respecto al quinto cuarto, la piel presentó los mayores porcentajes seguida de la cabeza y pies. Finalmente, la composición de las canales de la raza Mirandesa fue: 74,9 % de carne, 18,1 % de hueso y 7,0 % de grasa.The aim of this study was to evaluate the carcass characteristics of Mirandesa breed. To carry out this study, a total of 20 animals of Mirandesa breed were slaughter at 315 days. After 24 hours of slaughter, carcass weight and dressing percentage were determined, and morphometric measurements (carcass length, leg length, leg width, leg perimeter, chest external depth, chest internal depth and leg maximum perimeter) were performed and the following indexes were calculated: carcass compactness index and hindlimb compactness index and the main commercial cuts were obtained. Animals from Mirandesa breed presented a 293.7 kg live weight, a 152 kg carcass weight and a dressing percentage of 60.5 %. Regarding morphometric measurements, animals from Mirandesa breed showed a carcass length of 110 cm, leg length of 69 cm and leg perimeter of 89.8 cm. The values for the carcass compactness index and hindlimb compactness index were 1.4 and 3.7, respectively. Respecting fifth quarter, skin showed the highest percentages following by head and feet. Finally, the percentages of Mirandesa breed’s carcass quartering were 74.9 % for meat, 18.1 % for bone and 7.0 % for fat.info:eu-repo/semantics/publishedVersio

Influence of the rainfall in the content of nutrients in litter in agroforestry systems managed with burning and without burning in Amazon.

This study evaluated the nutrient content of the litter, testing different treatments with burning and no burning, of the vegetation, to identify which one provides better efficiency in operation and production of nutrients in different seasonal conditions. The study area is located on the property of the family farmer, initially selected by a diagnosis socioeconomic, community Benjamin Constant, in northeastern Para. Litter was collected during two periods: dry season (November) and rainy (March) in 2009. For the collection of litter samples, we used collectors measuring (0.25 × 0.25 m2), which were placed directly on the soil surface. The collected material was stored in paper bags and taken to the laboratory for Chemical Analysis of the Brazilian Agricultural Research Corporation (EMBRAPA), which was determined by analyses of macronutrients (N, P, K, Ca, Mg, Na) and micronutrients (Fe, Cu, Mn, Zn). The highest concentrations of macronutrients were found in N for agroforestry systems with and without burning in two seasons (wet and dry). All macronutrients showed influence of seasonality, which was verified by the wide variation in nutritional behavior. The decreasing concentration of nutrients was presented N > Ca > Mg > Na > K > P in agroforestry system with burning, with maximum values of all nutrients in the rainy season, and N, P, K, Ca, Na in higher concentrations in agroforestry system without burning, and showed only the Mg peak in agroforestry system with burning. The behavior of the concentration of nutrients was opposite to that observed one, for all elements analyzed showed a reduction in the concentrations of nutrients in the dry season. The decreasing concentration of nutrients was presented Fe > Mn > Zn > Cu