Deep griz GMOS Imaging of the Dwarf Irregular Galaxy Kar 50

Images obtained with the Gemini Multi-Object Spectrograph (GMOS) are used to investigate the stellar content and distance of the dwarf irregular galaxy Kar 50. The brightest object is an HII region, and the bright stellar content is dominated by stars with g'-r' < 0. The tips of the main sequence and the red giant branch are tentatively identified near r' = 24.9 and i' = 25.5, respectively. The galaxy has a blue integrated color with no significant color gradient, and we conclude that Kar 50 has experienced a recent galaxy-wide episode of star formation. The distance estimated from the brightest blue stars indicates that Kar 50 is behind the M81 group, and this is consistent with the tentative RGB-tip brightness. Kar 50 has a remarkably flat central surface brightness profile, even at wavelengths approaching 1um, although there is no evidence of a bar. In the absence of another large star-forming episode, Kar 50 will evolve into a very low surface brightness galaxy.Comment: 17 pages of text and 8 postscript figures. Accepted for publication in the PAS

Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements

BACKGROUND: Pleural effusion is a common cause of dyspnea in cats. N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) measurement, using a first‐generation quantitative ELISA, in plasma and pleural fluid differentiates cardiac from noncardiac causes of pleural effusion. HYPOTHESIS/OBJECTIVES: To determine whether NT‐proBNP measurements using second‐generation quantitative ELISA and point‐of‐care (POC) tests in plasma and pleural fluid distinguish cardiac from noncardiac pleural effusions and how results compare to the first‐generation ELISA. ANIMALS: Thirty‐eight cats (US cohort) and 40 cats (UK cohort) presenting with cardiogenic or noncardiogenic pleural effusion. METHODS: Prospective cohort study. Twenty‐one and 17 cats in the US cohort, and 22 and 18 cats in the UK cohort were classified as having cardiac or noncardiac pleural effusion, respectively. NT‐proBNP concentrations in paired plasma and pleural fluid samples were measured using second‐generation ELISA and POC assays. RESULTS: The second‐generation ELISA differentiated cardiac from noncardiac pleural effusion with good diagnostic accuracy (plasma: sensitivity, 95.2%, specificity, 82.4%; pleural fluid: sensitivity, 100%, specificity, 76.5%). NT‐proBNP concentrations were greater in pleural fluid (719 pmol/L (134–1500)) than plasma (678 pmol/L (61–1500), P = 0.003), resulting in different cut‐off values depending on the sample type. The POC test had good sensitivity (95.2%) and specificity (87.5%) when using plasma samples. In pleural fluid samples, the POC test had good sensitivity (100%) but low specificity (64.7%). Diagnostic accuracy was similar between first‐ and second‐generation ELISA assays. CONCLUSIONS AND CLINICAL IMPORTANCE: Measurement of NT‐proBNP using a quantitative ELISA in plasma and pleural fluid or POC test in plasma, but not pleural fluid, distinguishes cardiac from noncardiac causes of pleural effusion in cats

Atmospheric concentrations of carbon dioxide and its isotopic composition in southern Poland: comparison of high-altitude mountain site and a near-by urban environment

International audienceThe results of regular observations of atmospheric CO2 mixing ratios and its carbon isotope composition (?13C, ?14C), carried out at two continental sites located in central Europe are presented and discussed. The sites (Kasprowy Wierch, 49°14' N, 19°59' E, 1989 m a.s.l.; Krakow, 50°04' N, 19°55' E, 220 m a.s.l.), are located in two contrasting environments: (i) high-altitude mountaneous area, relatively free of anthropogenic influences, and (ii) typical urban environment with numerous local sources of carbon dioxide. Despite of relative proximity of those sites (ca. 100 km), substantial differences in both the recorded CO2 levels and their isotopic composition were detected. The CO2 mixing ratios measured in the urban atmosphere revealed quasi-permanent excess concentration of this gas when compared with near-by background atmosphere. The annual mean CO2 concentration recorded in Krakow in 2004 was almost 10% higher than that recorded at high-altitude mountain site (Kasprowy Wierch). Such effect is occuring probably in all urban centers. Carbon isotopic composition of atmospheric CO2 proved to be efficient tool for identification the surface CO2 fluxes into the atmosphere related to fossil fuel burning and their influence on the recorded levels of this gas in the local atmosphere. The available records of ?14C for Krakow and Kasprowy Wierch suggest gradual reduction of 14C-free CO2 fluxes into the urban atmosphere of Krakow in the past several years

All-cause and cause-specific mortality in individuals with zero and minimal coronary artery calcium: A long-term, competing risk analysis in the Coronary Artery Calcium Consortium.

Background and aimsThe long-term associations between zero, minimal coronary artery calcium (CAC) and cause-specific mortality are currently unknown, particularly after accounting for competing risks with other causes of death.MethodsWe evaluated 66,363 individuals from the CAC Consortium (mean age 54 years, 33% women), a multi-center, retrospective cohort study of asymptomatic individuals undergoing CAC scoring for clinical risk assessment. Baseline evaluations occurred between 1991 and 2010.ResultsOver a mean of 12 years of follow-up, individuals with CAC = 0 (45% prevalence, mean age 45 years) had stable low rates of coronary heart disease (CHD) death, cardiovascular disease (CVD) death (ranging 0.32 to 0.43 per 1000 person-years), and all-cause death (1.38-1.62 per 1000 person-years). Cancer was the predominant cause of death in this group, yet rates were also very low (0.47-0.79 per 1000 person-years). Compared to CAC = 0, individuals with CAC 1-10 had an increased multivariable-adjusted risk of CVD death only under age 40. Individuals with CAC&gt;10 had multivariable-adjusted increased risks of CHD death, CVD death and all-cause death at all ages, and a higher proportion of CVD deaths.ConclusionsCAC = 0 is a frequent finding among individuals undergoing CAC scanning for risk assessment and is associated with low rates of all-cause death at 12 years of follow-up. Our results support the emerging consensus that CAC = 0 represents a unique population with favorable all-cause prognosis who may be considered for more flexible treatment goals in primary prevention. Detection of any CAC in young adults could be used to trigger aggressive preventive interventions

Red Supergiants in the Disk of M81: Tracing the Spatial Distribution of Star Formation 25 Million Years in the Past

Near-infrared images are used to investigate the brightest red stars in the disk of the nearby spiral galaxy M81. Red supergiants (RSGs) form a well-defined sequence on the color-magnitude diagrams (CMDs) that peaks near M_K = -11.5; RSGs with this peak brightness are seen throughout all fields that were studied, indicating that star formation occured over a large part of the M81 disk only ~ 10 Myr in the past. The number of RSGs per unit integrated K-band light is compared at various locations in the disk. We conclude that star-forming activity in M81 during the past 10 - 25 Myr (1) was distributed over a larger fraction of the disk than it is at the present day, and (2) was not restricted to a given radial interval, but was distributed in a manner that closely followed the stellar mass profile. Star counts indicate that the mean SFR of M81 between 10 and 25 Myr in the past was ~ 0.1 solar masses per year, which is not greatly different from the present day SFR estimated from Halpha and FUV emission.Comment: 21 pages of text and 7 postscript figures; to appear in the PAS

Near-Infrared Adaptive Optics Imaging of the Central Regions of Nearby Sc Galaxies. II. NGC 247 and NGC 2403

J, H, and K' images obtained with the Canada-France-Hawaii Telescope adaptive optics system are used to investigate the star-forming histories of the central regions of the Sc galaxies NGC 247 and NGC 2403. The brightest resolved red stars within 15 arcsec of the nucleus of each galaxy are red supergiants, indicating that the central few hundred parsecs of these galaxies experienced star formation within the last ~ 0.1 Gyr. However, when averaged over Gyr time scales, the star-forming histories of the inner disks of these galaxies have been remarkably similar, as expected if the long-term evolution of disks is defined by local characteristics such as mass density. It is demonstrated that NGC 247 and NGC 2403, like M33, harbour nuclear star clusters with stellar contents that differ from the surrounding central light concentrations. The nucleus of NGC 2403 is significantly bluer than that of the other two galaxies and the K-band surface brightnesses near the centers of NGC 247 and NGC 2403 are 1 -- 2 mag per square arcsec lower than in M33. Finally, it is noted that young or intermediate-age nuclear star clusters are a common occurence in nearby spirals, indicating that nuclear star formation in these objects is either continuous or episodic on time scales of 0.1 - 1 Gyr.Comment: 27 pages of text and 14 figures; to appear in the Astronomical Journa

Sympatho-Excitatory Response to Pulmonary Chemosensitive Spinal Afferent Activation in Anesthetized, Vagotomized Rats

The sensory innervation of the lung is well known to be innervated by nerve fibers of both vagal and sympathetic origin. Although the vagal afferent innervation of the lung has been well characterized, less is known about physiological effects mediated by spinal sympathetic afferent fibers. We hypothesized that activation of sympathetic spinal afferent nerve fibers of the lung would result in an excitatory pressor reflex, similar to that previously characterized in the heart. In this study, we evaluated changes in renal sympathetic nerve activity (RSNA) and hemodynamics in response to activation of TRPV1-sensitive pulmonary spinal sensory fibers by agonist application to the visceral pleura of the lung and by administration into the primary bronchus in anesthetized, bilaterally vagotomized, adult Sprague-Dawley rats. Application of bradykinin (BK) to the visceral pleura of the lung produced an increase in mean arterial pressure (MAP), heart rate (HR), and RSNA. This response was significantly greater when BK was applied to the ventral surface of the left lung compared to the dorsal surface. Conversely, topical application of capsaicin (Cap) onto the visceral pleura of the lung, produced a biphasic reflex change in MAP, coupled with increases in HR and RSNA which was very similar to the hemodynamic response to epicardial application of Cap. This reflex was also evoked in animals with intact pulmonary vagal innervation and when BK was applied to the distal airways of the lung via the left primary bronchus. In order to further confirm the origin of this reflex, epidural application of a selective afferent neurotoxin (resiniferatoxin, RTX) was used to chronically ablate thoracic TRPV1-expressing afferent soma at the level of T1-T4 dorsal root ganglia pleura. This treatment abolished all sympatho-excitatory responses to both cardiac and pulmonary application of BK and Cap in vagotomized rats 9-10 weeks post-RTX. These data suggest the presence of an excitatory pulmonary chemosensitive sympathetic afferent reflex. This finding may have important clinical implications in pulmonary conditions inducing sensory nerve activation such as pulmonary inflammation and inhalation of chemical stimuli