Pacific contribution to the early twentieth-century warming in the Arctic

Arctic surface temperature warmed more than twice as fast as global temperature during the early twentieth century, similar to that during the recent global warming. This Arctic warming has been attributed to both external forcing1 and internal variability associated with atmospheric dynamics2,3 and Atlantic Ocean temperature4 in combination with Pacific variability5. Here we show, through coupled climate model experiments that superpose externally forced and dynamically driven changes, that Pacific decadal variability alone was a key contributor to the early twentieth century Arctic warming. Sea surface temperatures in the model are phased to observations by prescribing historical wind variations over the Pacific, which drive thermodynamically consistent decadal variations. During the early twentieth century, the Pacific Decadal Oscillation (PDO) transitioned to a positive phase with a concomitant deepening of the Aleutian Low that warms the Arctic by poleward low-level advection of extratropical air. In addition, our experiments revealed that the implemented Pacific surface changes weaken the polar vortex, which leads to subsidence-induced adiabatic heating of the Arctic surface. Thus, our results suggest that the observed recent shift to the positive PDO phase6 will intensify Arctic warming in the forthcoming decades.acceptedVersio

Advanced and controlled drug delivery systems in clinical disease management

Advanced and controlled drug delivery systems are important for clinical disease management. In this review the most important new systems which have reached clinical application are highlighted. Microbiologically controlled drug delivery is important for gastrointestinal diseases like ulcerative colitis and distally controlled release systems have improved patient compliance and decreased side effects. In the treatment of intractable pain the spinal and transdermal route is well documented. In neurology the flattened peak-through levels of antiepileptic drugs and anti Parkinson's drugs represents a more predictable kinetic profile. Tracheal delivery of corticosteroids and sympaticommimetics in asthma and Chronic Obstructive Pulmonary Disease is fully accepted in clinical practice: delivery by this route results in better efficacy and a better safety profile. In gynaecology the delivery of pulsatile hormones (LHRH) is used for pregnancy induction, while transdermal oestrogens are promising in the prevention of osteoporosis. In surgical practice the use of antibiotic impregnated bone cement and antibiotic impregnated biodegradable collagens is well established. To prevent infections intravascular catheters coated with heparin or antibiotics are used. In ophthalmology the Ocusert(R) systems provide a controlled release of different drugs in the eye. Most spectacular is the clinical introduction of the first liposomal drugs: amfotericine B and daunorubicine. Liposomal formulations of these drugs have enhanced activity and decreased toxicity compared to conventional formulations