Embodied space-pitch associations are shaped by language

Height-pitch associations are claimed to be universal and independent of language, but this claim remains controversial. The present study sheds new light on this debate with a multimodal analysis of individual sound and melody descriptions obtained in an interactive communication paradigm with speakers of Dutch and Farsi. The findings reveal that, in contrast to Dutch speakers, Farsi speakers do not use a height-pitch metaphor consistently in speech. Both Dutch and Farsi speakers’ co-speech gestures did reveal a mapping of higher pitches to higher space and lower pitches to lower space, and this gesture space-pitch mapping tended to co-occur with corresponding spatial words (high-low). However, this mapping was much weaker in Farsi speakers than Dutch speakers. This suggests that cross-linguistic differences shape the conceptualization of pitch and further calls into question the universality of height-pitch associations

Absorption coefficient dependent non-linear properties of thin film luminescent solar concentrators

This research article studied absorption coefficient dependent losses and efficiency of thin film luminescent solar concentrator (LSC). The optimum absorption coefficient was determined by fabricating red dye doped thin film LSCs with varying absorption coefficients of 24–202 cm-1. The optical, electrical, and ray-trace model predicted results were compared to establish the optimum absorption coefficient for fabricated thin film LSCs. The optical and electrical efficiencies of thin film LSCs are a function of absorption coefficient; follow linearly at lower values, gradually becoming non- linear at higher values of absorption coefficient which restricts the overall efficiency. The multi layered ray–trace model predicted results deviated from the experimental results at high absorption coefficient. Non-linearity was introduced by losses mechanism of re-absorption, resonant energy transfer (RET), and scattering in thin film LSCs. Re-absorption losses were found to be dependent on optical path-length and absorption coefficient of thin film. They were identified and quantified through locally collected emission and optical path-length in thin film LSCs. Re-absorption losses caused a red shift in emission peak by ≈ 20 nm as the absorption coefficient increased from 24 to 202 cm-1. RET decreased fluorescence life time of dye from 5 ns to 2 ns for the absorption coefficient increased from 24–202 cm-1. These absorption coefficient dependent losses limit the optical and electrical efficiency of thin film LSC devices, and compared with bulk LSC

Expanding the Circuitry of Pluripotency by Selective Isolation of Chromatin-Associated Proteins

Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4, Sox2, and Nanog (OSN), yet a systematic investigation of the composition and dynamics of the OSN protein network specifically on chromatin is still missing. Here we have developed a method combining ChIP with selective isolation of chromatin-associated proteins (SICAP) followed by mass spectrometry to identify chromatin-bound partners of a protein of interest. ChIP-SICAP in mouse embryonic stem cells (ESCs) identified over 400 proteins associating with OSN, including several whose interaction depends on the pluripotent state. Trim24, a previously unrecognized protein in the network, converges with OSN on multiple enhancers and suppresses the expression of developmental genes while activating cell cycle genes. Consistently, Trim24 significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency. Collectively, ChIP-SICAP provides a powerful tool to decode chromatin protein composition, further enhanced by its integrative capacity to perform ChIP-seq

Stochastic model for nucleosome sliding in the presence of DNA ligands

Heat-induced mobility of nucleosomes along DNA is an experimentally well-studied phenomenon. A recent experiment shows that the repositioning is modified in the presence of minor-groove binding DNA ligands. We present here a stochastic three-state model for the diffusion of a nucleosome along DNA in the presence of such ligands. It allows us to describe the dynamics and the steady state of such a motion analytically. The analytical results are in excellent agreement with numerical simulations of this stochastic process.With this model, we study the response of a nucleosome to an external force and how it is affected by the presence of ligands.Comment: 10 pages, 8 figures, submitted to Eur. Phys. J.

Acceleration and Substructure Constraints in a Quasar Outflow

We present observations of probable line-of-sight acceleration of a broad absorption trough of C IV in the quasar SDSS J024221.87+004912.6. We also discuss how the velocity overlap of two other outflowing systems in the same object constrains the properties of the outflows. The Si IV doublet in each system has one unblended transition and one transition which overlaps with absorption from the other system. The residual flux in the overlapping trough is well fit by the product of the residual fluxes in the unblended troughs. For these optically thick systems to yield such a result, at least one of them must consist of individual subunits rather than being a single structure with velocity-dependent coverage of the source. If these subunits are identical, opaque, spherical clouds, we estimate the cloud radius to be r = 3.9 10^15 cm. If they are identical, opaque, linear filaments, we estimate their width to be w = 6.5 10^14 cm. These subunits are observed to cover the Mg II broad emission line region of the quasar, at which distance from the black hole the above filament width is equal to the predicted scale height of the outer atmosphere of a thin accretion disk. Insofar as that scale height is a natural size scale for structures originating in an accretion disk, these observations are evidence that the accretion disk can be a source of quasar absorption systems. Based on data from ESO program 075.B-0190(A).Comment: 14 emulateapj pages, 7 figures, ApJ in pres

Some Physiological Effects of Nanofertilizers on Wheat-Aphid Interactions

The increasing use of nanofertilizers in modern agriculture and their impact on crop yield and pest management require further research. In this study, the effects of nano-Fe, -Zn, and -Cu (which are synthesized based on nanochelating technology), and urea (N) fertilizers on the antioxidant activities of wheat plants (cv. Chamran), and the wheat green aphid Schizaphis graminum (Rondani) are investigated. The authors observed the highest levels of phenolics in non-infested nano-Zn-treated plants (26% higher compared with control). The highest H2O2 levels are in the infested and non-infested nano-Zn-treated and infested nano-Fe-treated plants (in infested nano-Zn and nano-Fe treated plants, 18% and non-infested nano-Zn-treated plants, 28% higher compared with control). The highest peroxidase (POX) activity is observed in the infested and non-infested N-treated and non-infested water-treated plants (almost 14%, 37%, and 46% higher than control, respectively). The lowest activity is in the infested plants’ nano-Zn and -Fe treatments (almost 7 and 5 folds lower compared to the control, respectively). The highest and lowest catalase (CAT) activity are in the infested N-treated plants (almost 42% higher than control) and water-treated plants, respectively. The infested nano-Zn, -Fe, -Cu and Hoagland-treated plants showed the highest superoxide dismutase (SOD) activity. Regarding the antioxidant enzyme activities of S. graminum, the highest POX activity is in the nano-Cu treatment (more than two folds higher compared with control); the highest CAT and SOD activities are in the nano-Cu and -Zn treatments. It can be concluded that the application of nanofertilizers caused increasing effects on the wheat plant’s antioxidant system and its resistance to S. graminum

Evaluating the effect of a herb on the control of blood glucose and insulin-resistance in patients with advanced type 2 diabetes (a double-blind clinical trial)

Background: Different benefits of various herbal medicines in decreasing blood sugar have been reported in different clinical trials so far. Considering the growing tendency toward these combinations and the booming market, inappropriate advice is growing accordingly. Hence, it is necessary to evaluate the effects and possible complications of such combinations on health status and blood glucose control. Methods: Two 38-subject groups were formed and a 12-week treatment program was administered for both groups. The inclusion criteria were failure to control blood glucose with two oral medicines, unwillingness to inject insulin. The medicine was prepared in capsules by Booali Company. Each capsule weighed 750 mg and contained nettle leaf 20 (w/w), berry leaf 10 (w/w), onion and garlic 20 (w/w), fenugreek seed 20 (w/w), walnut leaf 20 (w/w), and cinnamon bark 10 (w/w) all in powder. Results: At the beginning of the study, there was no significant difference between the subjects regarding the evaluated parameters, but after the intervention, the level of glucose was significantly lower in fasting (P=0.0001) and 2-hour postprandial (P=0.002) levels. The level of glycated hemoglobin A1c (HbA1c) (P=0.0001) also decreased from 0.33±9.72 to 0.20±8.39 . Finally, the level of insulin resistance reduced from 1.9±4.1 to 1.4±2.6 (P=0.001) after consuming herbal medicine. Conclusion: According to the results of the current study, the herbal combination was effective in controlling blood sugar, and considering the reduction of HbA1c by 1.31 , it seems that the herbal combination is an effective medicine to treat diabetes. © 2020 Babol University of Medical Sciences. All rights reserved

Chromatin-contact atlas reveals disorder-mediated protein interactions and moonlighting chromatin-associated RBPs

RNA-binding proteins (RBPs) play diverse roles in regulating co-transcriptional RNA-processing and chromatin functions, but our knowledge of the repertoire of chromatin-associated RBPs (caRBPs) and their interactions with chromatin remains limited. Here, we developed SPACE (Silica Particle Assisted Chromatin Enrichment) to isolate global and regional chromatin components with high specificity and sensitivity, and SPACEmap to identify the chromatin-contact regions in proteins. Applied to mouse embryonic stem cells, SPACE identified 1459 chromatin-associated proteins, ∼48% of which are annotated as RBPs, indicating their dual roles in chromatin and RNA-binding. Additionally, SPACEmap stringently verified chromatin-binding of 403 RBPs and identified their chromatin-contact regions. Notably, SPACEmap showed that about 40% of the caRBPs bind chromatin by intrinsically disordered regions (IDRs). Studying SPACE and total proteome dynamics from mES cells grown in 2iL and serum medium indicates significant correlation (R = 0.62). One of the most dynamic caRBPs is Dazl, which we find co-localized with PRC2 at transcription start sites of genes that are distinct from Dazl mRNA binding. Dazl and other PRC2-colocalised caRBPs are rich in intrinsically disordered regions (IDRs), which could contribute to the formation and regulation of phase-separated PRC condensates. Together, our approach provides an unprecedented insight into IDR-mediated interactions and caRBPs with moonlighting functions in native chromatin

Toxicity of some biorational and conventional insecticides to cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae) and its ectoparasitoid, Habrobracon hebetor (Hymenoptera: Braconidae)

Insect growth regulators and spinosyns which are physiologically and ecologically selective, respectively, have been investigated as replacements or complements to non-selective conventional insecticides. The effects of diflubenzuron, hexaflumuron, profenofos, spinosad and thiodicarb were assessed on the 1st instars of cotton bollworm, Helicoverpa armigera (Hübner) using dietary and leaf disc bioassay methods. Based on modes of action of the insecticides tested, the mortalities were recorded after 24 h in profenofos, thiodicarb and spinosad experiments and after 120 h in hexaflumuron and diflubenzuron treatments. The LC50 values for diflubenzuron, hexaflumuron, profenofos, spinosad and thiodicarb in dietary method were 595.05, 0.31, 3.69, 0.13 and 11.2 mg ai/L; and in leaf disc method, they were >2000, 0.46, 9.55, 0.2 and 15.52 mg ai/L, respectively. The effects of these insecticides on adult Habrobracon hebetor Say, an ectoparasitoid of cotton bollworm were tested using residual method. The mortalities were recorded after 24 h in all treatments. The LC50 values for diflubenzuron, hexaflumuron, profenofos, spinosad and thiodicarb for females were >2000, >2000, 12.44, 15.64 and 81.04 mg ai/L, respectively and for males, they were >2000, >2000, 6.91, 11.73 and 40.39 mg ai/L, respectively. In this study spinosad and hexaflumuron seemed to be more useful than the other insecticides due to their higher toxicity to H. armigera and lower toxicity to H. hebetor

Spontaneous pneumothorax and pneumomediastinum as a rare complication of COVID-19 pneumonia: Report of 6 cases

Spontaneous pneumothorax (SPT) and pneumomediastinum (SPM) have been reported as uncommon complications of coronavirus disease (COVID-19) pneumonia. The exact incidence and risk factors are still unrecognized. We report 6 nonventilated, COVID-19 pneumonia cases with SPT and SPM and their outcomes. The major risk factors for development of SPT and SPM in our patients were male gender, advance age, and pre-existing lung disease. These complications may occur in the absence of mechanical ventilation and associated with increasing morbidity (chest tube insertion, sepsis, hospital admission) and mortality. SPT and SPM should be considered as a potential predictive factor for adverse outcome and probable cause of unexplained deterioration of clinical condition in COVID-19 pneumonia. © 2021 The Author