A Preliminary Evaluation of Mounds to Divert Wayward Vehicles Away from Rigid Obstructions

In the summer of 1965, the first fatality report involving an interstate median bridge pier in Kentucky caused concern among state and national officials for the safety of motorists who perchance or otherwise enter upon a collision course toward an unprotected bridge pier. A consensus of opinion seemed to indicate that some form of attenuation or deflection device was necessary. Early innovations employed various short guardrail configurations to deflect wayward vehicles from the piers. The use of small, short sections has since evolved until present methods include surrounding the bridge pier with several hundred feet of guardrail, including ramped-end treatment (see Figure 1). The use of guardrail has not been questioned from the standpoint of safety design, yet some effort has been applied by Kentucky and other states to finding an alternative approach. From these efforts, the use of mounds to decelerate and deflect vehicles originated. It was thought that this design concept was consistent with current safety developments as well as being an economical treatment of the problem, since most of the work involved in constructing the mound can be done during grade and drain construction using natural materials available on location. These mounds have since been constructed on certain interstate projects and on all bridge locations of the Jackson Purchase (51.4 miles) and Pennyrile (56.6 miles) Parkways in Kentucky. Having found no records of accidents involving these mounds in the interim, there has been no substantial means of evaluating the effectiveness of this innovation in preventing or reducing the severity of collisions with bridge piers. Consequently, it was decided that low speed excursions over a mound might provide a basis for evaluation. The Division of Research made a series of driver-controlled traverses at low speeds on a typical site constructed on a 60-foot median. The purpose of this report is to summarize the results obtained from these initial, low-speed tests and, in so doing, attempt to make some determination of the reliability of this particular type of earthwork. It is anticipated that these low-speed tests will be supplemented eventually by testing at higher speeds, using some form of remote guidance system in place of the human driver. Also, it must be emphasized that conclusions drawn from this report apply only to low-speed encroachments. Additional effects which may be encountered during high-speed testing can only be hypothesized at this time

The Behavior of Coupled Automata

We study the nature of statistical correlations that develop between systems of interacting self-organized critical automata (sandpiles). Numerical and analytical findings are presented describing the emergence of “synchronization” between sandpiles and the dependency of this synchronization on factors such as variations in coupling strength, toppling rule probabilities, symmetric versus asymmetric coupling rules, and numbers of sandpiles

The biomechanics of amnion rupture: an X-ray diffraction study

Pre-term birth is the leading cause of perinatal and neonatal mortality, 40% of which are attributed to the pre-term premature rupture of amnion. Rupture of amnion is thought to be associated with a corresponding decrease in the extracellular collagen content and/or increase in collagenase activity. However, there is very little information concerning the detailed organisation of fibrillar collagen in amnion and how this might influence rupture. Here we identify a loss of lattice like arrangement in collagen organisation from areas near to the rupture site, and present a 9% increase in fibril spacing and a 50% decrease in fibrillar organisation using quantitative measurements gained by transmission electron microscopy and the novel application of synchrotron X-ray diffraction. These data provide an accurate insight into the biomechanical process of amnion rupture and highlight X-ray diffraction as a new and powerful tool in our understanding of this process

Volume-energy correlations in the slow degrees of freedom of computer-simulated phospholipid membranes

Constant-pressure molecular-dynamics simulations of phospholipid membranes in the fluid phase reveal strong correlations between equilibrium fluctuations of volume and energy on the nanosecond time-scale. The existence of strong volume-energy correlations was previously deduced indirectly by Heimburg from experiments focusing on the phase transition between the fluid and the ordered gel phases. The correlations, which are reported here for three different membranes (DMPC, DMPS-Na, and DMPSH), have volume-energy correlation coefficients ranging from 0.81 to 0.89. The DMPC membrane was studied at two temperatures showing that the correlation coefficient increases as the phase transition is approached

Water Vapor Measurements by Howard University Raman Lidar during the WAVES 2006 Campaign

Retrieval of water vapor mixing ratio using the Howard University Raman Lidar is presented with emphasis on three aspects: i) performance of the lidar against collocated radiosondes and Raman lidar, ii) investigation of the atmospheric state variables when poor agreement between lidar and radiosondes values occurred and iii) a comparison with satellite-based measurements. The measurements were acquired during the Water Vapor Validation Experiment Sondes/Satellites 2006 field campaign. Ensemble averaging of water vapor mixing ratio data from ten night-time comparisons with Vaisala RS92 radiosondes shows on average an agreement within 10 % up to approx. 8 km. A similar analysis of lidar-to-lidar data of over 700 profiles revealed an agreement to within 20 % over the first 7 km (10 % below 4 km). A grid analysis, defined in the temperature - relative humidity space, was developed to characterize the lidar - radiosonde agreement and quantitatively localizes regions of strong and weak correlations as a function of altitude, temperature or relative humidity. Three main regions of weak correlation emerge: i) regions of low relative humidity and low temperature, ii) moderate relative humidity at low temperatures and iii) low relative humidity at moderate temperatures. Comparison of Atmospheric InfraRed Sounder and Tropospheric Emission Sounder satellites retrievals of moisture with that of Howard University Raman Lidar showed a general agreement in the trend but the formers miss a lot of the details in atmospheric structure due to their low resolution. A relative difference of about 20 % is usually found between lidar and satellites measurements

Development and Implementation of an Academic-Community Partnership to Enhance Care among Homeless Persons

An academic-community partnership between a Health Care for the Homeless (HCH) clinic and a school of pharmacy was created in 2005 to provide medication education and identify medication related problems. The urban community based HCH clinic in the Richmond, VA area provides primary health care to the homeless, uninsured and underinsured. The center also offers eye care, dental care, mental health and psychiatric care, substance abuse services, case management, laundry and shower facilities, and mail services at no charge to those in need. Pharmacist services are provided in the mental health and medical clinics. A satisfaction survey showed that the providers and staff (n = 13) in the clinic were very satisfied with the integration of pharmacist services. The quality and safety of medication use has improved as a result of the academic-community collaborative. Education and research initiatives have also resulted from the collaborative. This manuscript describes the implementation, outcomes and benefits of the partnership for both the HCH clinic and the school of pharmacy. Type: Clinical Experienc

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

Peer reviewedPublisher PD