A New Genus of Agathidinae with the Description of a New Species Parasitic on \u3cem\u3eSamea Multiplicalis\u3c/em\u3e (Guenée)

A new genus of Agathidinae (Hymenoptera, Braconidae), Neothlipsis, is proposed to include 10 species. Nine of these species were formerly included in the polyphyletic genus Therophilus Wesmael 1837, formerly referred to as Bassus. A new species, Neothlipsis parysae, parasitic on Samea multiplicalis (Guenée), is described. The ten described species transferred to Neothlipsis are:, Neothlipsis agathoides, comb. n. for Bassus agathoides Newton and Sharkey 2000; Neothlipsis agilis, comb. n. for Bassus agilis Cresson 1868; Neothlipsis brevicauda, comb. n. for Bassus brevicaudus Muesebeck 1932; Neothlipsis californica, comb. n. for Bassus californicus Muesebeck 1927; Neothlipsis cincta, comb. n. for Microdus cinctus Cresson 1873; Neothlipsis coleophorae, comb. n. for Bassus coleophorae Rowher 1915; Neothlipsis discolor, comb. n. for Microdus discolor Cresson 1873; Neothlipsis nigricoxa, comb. n. for Microdus nigricoxus Provancher 1886; Neothlipsis petiolate, comb. n. for Bassus petiolatus Muesebeck 1932; Neothlipsis taeniativentris, comb. n. for Microdus taeniativentris Enderlein 1920. Phylogenetic analyses support the sister relationship between the new genus and Camptothlipsis. The type material of the new species is deposited at the Hymenoptera Institute Collection at the University of Kentucky, the United States National Museum, the Florida State Collection of Arthropods, and the Louisiana State Arthropod Museum

Tracking the global spread of vaccine sentiments: the global response to Japan's suspension of its HPV vaccine recommendation.

UNLABELLED: In June 2013 the Japanese Ministry of Health, Labor, and Welfare (MHLW) suspended its HPV vaccination recommendation after a series of highly publicized alleged adverse events following immunization stoked public doubts about the vaccine's safety. This paper examines the global spread of the news of Japan's HPV vaccine suspension through online media, and takes a retrospective look at non-Japanese media sources that were used to support those claiming HPV vaccine injury in Japan. METHODS: Two searches were conducted. One searched relevant content in an archive of Google Alerts on vaccines and vaccine preventable diseases. The second search was conducted using Google Search on January 6th 2014 and on July 18th 2014, using the keywords, "HPV vaccine Japan" and "cervical cancer vaccine Japan." Both searches were used as Google Searches render more (and some different) results than Google Alerts. RESULTS: Online media collected and analyzed totalled 57. Sixty 3 percent were published in the USA, 23% in Japan, 5% in the UK, 2% in France, 2% in Switzerland, 2% in the Philippines, 2% in Kenya and 2% in Denmark. The majority took a negative view of the HPV vaccine, the primary concern being vaccine safety. DISCUSSION: The news of Japan's suspension of the HPV vaccine recommendation has traveled globally through online media and social media networks, being applauded by anti-vaccination groups but not by the global scientific community. The longer the uncertainty around the Japanese HPV vaccine recommendation persists, the further the public concerns are likely to travel

Energy-optimal Timetable Design for Sustainable Metro Railway Networks

We present our collaboration with Thales Canada Inc, the largest provider of communication-based train control (CBTC) systems worldwide. We study the problem of designing energy-optimal timetables in metro railway networks to minimize the effective energy consumption of the network, which corresponds to simultaneously minimizing total energy consumed by all the trains and maximizing the transfer of regenerative braking energy from suitable braking trains to accelerating trains. We propose a novel data-driven linear programming model that minimizes the total effective energy consumption in a metro railway network, capable of computing the optimal timetable in real-time, even for some of the largest CBTC systems in the world. In contrast with existing works, which are either NP-hard or involve multiple stages requiring extensive simulation, our model is a single linear programming model capable of computing the energy-optimal timetable subject to the constraints present in the railway network. Furthermore, our model can predict the total energy consumption of the network without requiring time-consuming simulations, making it suitable for widespread use in managerial settings. We apply our model to Shanghai Railway Network's Metro Line 8 -- one of the largest and busiest railway services in the world -- and empirically demonstrate that our model computes energy-optimal timetables for thousands of active trains spanning an entire service period of one day in real-time (solution time less than one second on a standard desktop), achieving energy savings between approximately 20.93% and 28.68%. Given the compelling advantages, our model is in the process of being integrated into Thales Canada Inc's industrial timetable compiler.Comment: 28 pages, 8 figures, 2 table

Calcium puffs are generic InsP₃-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses

Elementary Ca2+ signals, such as "Ca2+ puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca2+ signalling. We characterized Ca2+ puffs in six cell types that expressed differing ratios of the three inositol 1,4,5-trisphosphate receptor isoforms. The amplitudes, spatial spreads and kinetics of the events were similar in each of the cell types. The resemblance of Ca2+ puffs in these cell types suggests that they are a generic elementary Ca2+ signal and, furthermore, that the different inositol 1,4,5-trisphosphate isoforms are functionally redundant at the level of subcellular Ca2+ signalling. Hormonal stimulation of SH-SY5Y neuroblastoma cells and HeLa cells for several hours downregulated inositol 1,4,5-trisphosphate expression and concomitantly altered the properties of the Ca2+ puffs. The amplitude and duration of Ca2+ puffs were substantially reduced. In addition, the number of Ca2+ puff sites active during the onset of a Ca2+ wave declined. The consequence of the changes in Ca2+ puff properties was that cells displayed a lower propensity to trigger regenerative Ca2+ waves. Therefore, Ca2+ puffs underlie inositol 1,4,5-trisphosphate signalling in diverse cell types and are focal points for regulation of cellular responses