435 research outputs found
What do we know about communicating risk? A brief review and suggestion for contextualising serious, but rare, risk, and the example of cox-2 selective and non-selective NSAIDs
BACKGROUND: Communicating risk is difficult. Although different methods have been proposed - using numbers, words, pictures or combinations - none has been extensively tested. We used electronic and bibliographic searches to review evidence concerning risk perception and presentation. People tend to underestimate common risk and overestimate rare risk; they respond to risks primarily on the basis of emotion rather than facts, seem to be risk averse when faced with medical interventions, and want information on even the rarest of adverse events. METHODS: We identified observational studies (primarily in the form of meta-analyses) with information on individual non-steroidal anti-inflammatory drug (NSAID) or selective cyclooxygenase-2 inhibitor (coxib) use and relative risk of gastrointestinal bleed or cardiovascular event, the background rate of events in the absence of NSAID or coxib, and the likelihood of death from an event. Using this information we present the outcome of additional risk of death from gastrointestinal bleed and cardiovascular event for individual NSAIDs and coxibs alongside information about death from other causes in a series of perspective scales. RESULTS: The literature on communicating risk to patients is limited. There are problems with literacy, numeracy and the human tendency to overestimate rare risk and underestimate common risk. There is inconsistency in how people translate between numbers and words. We present a method of communicating information about serious risks using the common outcome of death, using pictures, numbers and words, and contextualising the information. The use of this method for gastrointestinal and cardiovascular harm with NSAIDs and coxibs shows differences between individual NSAIDs and coxibs. CONCLUSION: Although contextualised risk information can be provided on two possible adverse events, many other possible adverse events with potential serious consequences were omitted. Patients and professionals want much information about risks of medical interventions but we do not know how best to meet expectations. The impact of contextualised information remains to be tested
The DRIFT Dark Matter Experiments
The current status of the DRIFT (Directional Recoil Identification From
Tracks) experiment at Boulby Mine is presented, including the latest limits on
the WIMP spin-dependent cross-section from 1.5 kg days of running with a
mixture of CS2 and CF4. Planned upgrades to DRIFT IId are detailed, along with
ongoing work towards DRIFT III, which aims to be the world's first 10 m3-scale
directional Dark Matter detector.Comment: Proceedings of the 3rd International conference on Directional
Detection of Dark Matter (CYGNUS 2011), Aussois, France, 8-10 June 201
First measurement of the Head-Tail directional nuclear recoil signature at energies relevant to WIMP dark matter searches
We present first evidence for the so-called Head-Tail asymmetry signature of
neutron-induced nuclear recoil tracks at energies down to 1.5 keV/amu using the
1m^3 DRIFT-IIc dark matter detector. This regime is appropriate for recoils
induced by Weakly Interacting Massive Particle (WIMPs) but one where the
differential ionization is poorly understood. We show that the distribution of
recoil energies and directions induced here by Cf-252 neutrons matches well
that expected from massive WIMPs. The results open a powerful new means of
searching for a galactic signature from WIMPs.Comment: 4 pages, 6 figures, 1 tabl
Low Energy Electron and Nuclear Recoil Thresholds in the DRIFT-II Negative Ion TPC for Dark Matter Searches
Understanding the ability to measure and discriminate particle events at the
lowest possible energy is an essential requirement in developing new
experiments to search for weakly interacting massive particle (WIMP) dark
matter. In this paper we detail an assessment of the potential sensitivity
below 10 keV in the 1 m^3 DRIFT-II directionally sensitive, low pressure,
negative ion time projection chamber (NITPC), based on event-by-event track
reconstruction and calorimetry in the multiwire proportional chamber (MWPC)
readout. By application of a digital smoothing polynomial it is shown that the
detector is sensitive to sulfur and carbon recoils down to 2.9 and 1.9 keV
respectively, and 1.2 keV for electron induced events. The energy sensitivity
is demonstrated through the 5.9 keV gamma spectrum of 55Fe, where the energy
resolution is sufficient to identify the escape peak. The effect a lower energy
sensitivity on the WIMP exclusion limit is demonstrated. In addition to recoil
direction reconstruction for WIMP searches this sensitivity suggests new
prospects for applications also in KK axion searches
Quenching Factor for Low Energy Nuclear Recoils in a Plastic Scintillator
Plastic scintillators are widely used in industry, medicine and scientific
research, including nuclear and particle physics. Although one of their most
common applications is in neutron detection, experimental data on their
response to low-energy nuclear recoils are scarce. Here, the relative
scintillation efficiency for neutron-induced nuclear recoils in a
polystyrene-based plastic scintillator (UPS-923A) is presented, exploring
recoil energies between 125 keV and 850 keV. Monte Carlo simulations,
incorporating light collection efficiency and energy resolution effects, are
used to generate neutron scattering spectra which are matched to observed
distributions of scintillation signals to parameterise the energy-dependent
quenching factor. At energies above 300 keV the dependence is reasonably
described using the semi-empirical formulation of Birks and a kB factor of
(0.014+/-0.002) g/MeVcm^2 has been determined. Below that energy the measured
quenching factor falls more steeply than predicted by the Birks formalism.Comment: 8 pages, 9 figure
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