ATP-binding cassette (ABC) transporters in normal and pathological lung

ATP-binding cassette (ABC) transporters are a family of transmembrane proteins that can transport a wide variety of substrates across biological membranes in an energy-dependent manner. Many ABC transporters such as P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP) are highly expressed in bronchial epithelium. This review aims to give new insights in the possible functions of ABC molecules in the lung in view of their expression in different cell types. Furthermore, their role in protection against noxious compounds, e.g. air pollutants and cigarette smoke components, will be discussed as well as the (mal)function in normal and pathological lung. Several pulmonary drugs are substrates for ABC transporters and therefore, the delivery of these drugs to the site of action may be highly dependent on the presence and activity of many ABC transporters in several cell types. Three ABC transporters are known to play an important role in lung functioning. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene can cause cystic fibrosis, and mutations in ABCA1 and ABCA3 are responsible for respectively Tangier disease and fatal surfactant deficiency. The role of altered function of ABC transporters in highly prevalent pulmonary diseases such as asthma or chronic obstructive pulmonary disease (COPD) have hardly been investigated so far. We especially focused on polymorphisms, knock-out mice models and in vitro results of pulmonary research. Insight in the function of ABC transporters in the lung may open new ways to facilitate treatment of lung diseases

Bathysabellaria Spinifera (Polychaeta: Sabellariidae), A New Species From Deep Water Off New Caledonia, Southwest Pacific Ocean

Volume: 109Start Page: 560End Page: 57

New Species Of Bathyal And Abyssal Sabellariidae (Annelida : Polychaeta) From Near New Caledonia (Southwest Pacific Ocean)

Volume: 111Start Page: 807End Page: 82

Effects a long terme du fonctionnement de l'usine maremotrice sur l'evolution du peuplement des sables fins vaseux de la Rance

Dynamic studies of the Abra alba-Melinna palmata muddy sand community from 1972 to 1982 show that after an initial recolonization until 1976 species richness and density exhibit a steady trend. Three groups of species and five main categories of population abundance evolution are deduced from qualitative and quantitative sampling. Rapid stabilization of abiotic factors occurs after the starting up of the tidal power dam in 1966 and the authors' evolutive scheme reflects both importance of hydrodynamic effects in the dispersion of benthic organisms and demographic strategies of main populations, especially annelids (80-90% of the community). Among the six annelid dominant species, four took part in the recolonization of the biotopa although they are able to live several years and possess a short pelagic stage in their larval development or none

Unusual Extramedullary Plasmacytoma: A Rare but Possible Cause of Lymphadenopathy in Chronic Lymphocytic Leukemia

Cervical bilateral lymphadenopathy is a frequent event during chronic lymphocytic leukemia (CLL) natural history. However, lymph node biopsy is generally not required as long as transformation into an aggressive lymphoma (Richter syndrome) is not suspected. We present here a rare case of CLL patient who developed progressive bilateral cervical lymph node and bilateral tonsillar hypertrophy. CLL front-line therapy was ineffective leading to adenectomy and diagnosis of concomitant extramedullary plasmacytoma. Radiotherapy did not result in the disappearance of lymphadenopathy. Adenectomy should be performed in CLL cases to avoid misdiagnosis

An integrative radiological, histopathological and molecular analysis of pediatric pontine histone-wildtype glioma with MYCN amplification (HGG-MYCN)

International audienc

EZHIP is a specific diagnostic biomarker for posterior fossa ependymomas, group PFA and diffuse midline gliomas H3-WT with EZHIP overexpression

International audienc

The pediatric supratentorial MYCN-amplified high-grade gliomas methylation class presents the same radiological, histopathological and molecular features as their pontine counterparts

International audienc