Constraining alternative polarization states of gravitational waves from individual black hole binaries using pulsar timing arrays

Pulsar timing arrays are sensitive to gravitational wave perturbations produced by individual supermassive black hole binaries during their early inspiral phase. Modified gravity theories allow for the emission of gravitational dipole radiation, which is enhanced relative to the quadrupole contribution for low orbital velocities, making the early inspiral an ideal regime to test for the presence of modified gravity effects. Using a theory-agnostic description of modified gravity theories based on the parametrized post-Einsteinian framework, we explore the possibility of detecting deviations from general relativity using simulated pulsar timing array data, and provide forecasts for the constraints that can be achieved. We generalize the enterprise pulsar timing software to account for possible additional polarization states and modifications to the phase evolution, and study how accurately the parameters of simulated signals can be recovered. We find that while a pure dipole model can partially recover a pure quadrupole signal, there is little possibility for confusion when the full model with all polarization states is used. With no signal present, and using noise levels comparable to those seen in contemporary arrays, we produce forecasts for the upper limits that can be placed on the amplitudes of alternative polarization modes as a function of the sky location of the source

Constraining alternative polarization states of gravitational waves from individual black hole binaries using pulsar timing arrays

Pulsar timing arrays are sensitive to gravitational wave perturbations produced by individual supermassive black hole binaries during their early inspiral phase. Modified gravity theories allow for the emission of gravitational dipole radiation, which is enhanced relative to the quadrupole contribution for low orbital velocities, making the early inspiral an ideal regime to test for the presence of modified gravity effects. Using a theory-agnostic description of modified gravity theories based on the parametrized post-Einsteinian framework, we explore the possibility of detecting deviations from general relativity using simulated pulsar timing array data, and provide forecasts for the constraints that can be achieved. We generalize the enterprise pulsar timing software to account for possible additional polarization states and modifications to the phase evolution, and study how accurately the parameters of simulated signals can be recovered. We find that while a pure dipole model can partially recover a pure quadrupole signal, there is little possibility for confusion when the full model with all polarization states is used. With no signal present, and using noise levels comparable to those seen in contemporary arrays, we produce forecasts for the upper limits that can be placed on the amplitudes of alternative polarization modes as a function of the sky location of the source

High Effectiveness of Broad Access Direct-Acting Antiviral Therapy for Hepatitis C in an Australian Real-World Cohort: The REACH-C Study

Australia was one of the first countries with unrestricted access to government subsidized direct-acting antiviral (DAA) therapy for adults with chronic hepatitis C virus. This study assessed real-world DAA treatment outcomes across a diverse range of Australian clinical services and evaluated factors associated with successful treatment and loss to follow-up. Real-world Effectiveness of Antiviral therapy in Chronic Hepatitis C (REACH-C) consisted a national observational cohort of 96 clinical services including specialist clinics and less traditional settings such as general practice. Data were obtained on consecutive individuals who commenced DAAs from March 2016 to June 2019. Effectiveness was assessed by sustained virological response ≥12 weeks following treatment (SVR) using intention-to-treat (ITT) and per-protocol (PP) analyses. Within REACH-C, 10,843 individuals initiated DAAs (male 69%; ≥50 years 52%; cirrhosis 22%). SVR data were available in 85% (9,174 of 10,843). SVR was 81% (8,750 of 10,843) by ITT and 95% (8,750 of 9,174) by PP. High SVR (≥92%) was observed across all service types and participant characteristics. Male gender (adjusted odds ratio [aOR] 0.56, 95% confidence interval [CI] 0.43-0.72), cirrhosis (aOR 0.52, 95% CI 0.41-0.64), recent injecting drug use (IDU; aOR 0.64, 95% CI 0.46-0.91) and previous DAA treatment (aOR 0.50, 95% CI 0.28-0.90) decreased the likelihood of achieving SVR. Multiple factors modified the likelihood of loss to follow-up including IDU ± opioid agonist therapy (OAT; IDU only: aOR 1.75, 95% CI 1.44-2.11; IDU + OAT: aOR 1.39, 95% CI 1.11-1.74; OAT only, aOR 1.36; 95% CI 1.13-1.68) and age (aOR 0.97, 95% CI 0.97-0.98). Conclusion: Treatment response was high in a diverse population and through a broad range of services following universal access to DAA therapy. Loss to follow-up presents a real-world challenge. Younger people who inject drugs were more likely to disengage from care, requiring innovative strategies to retain them in follow-up

Reproducibility of Standing Posture for X-Ray Radiography: A Feasibility Study of the BalancAid with Healthy Young Subjects

Unreliable spinal X-ray radiography measurement due to standing postural variability can be minimized by using positional supports. In this study, we introduce a balancing device, named BalancAid, to position the patients in a reproducible position during spinal X-ray radiography. This study aimed to investigate the performance of healthy young subjects’ standing posture on the BalancAid compared to standing on the ground mimicking the standard X-rays posture in producing a reproducible posture for the spinal X-ray radiography. A study on the posture reproducibility measurement was performed by taking photographs of 20 healthy young subjects with good balance control standing on the BalancAid and the ground repeatedly within two consecutive days. We analyzed nine posterior–anterior (PA) and three lateral (LA) angles between lines through body marks placed in the positions of T3, T7, T12, L4 of the spine to confirm any translocations and movements between the first and second day measurements. No body marks repositioning was performed to avoid any error. Lin’s CCC test on all angles comparing both standing postures demonstrated that seven out of nine angles in PA view, and two out of three angles in LA view gave better reproducibility for standing on the BalancAid compared to standing on the ground. The PA angles concordance is on average better than that of the LA angles

Electrocochleography and Subjective Methods for the Diagnosis of Meniere’s disease

between electrocochleography (ECochG) measures and the subjective scores based on the clinical guidelines provided by the American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing Equilibrium (AAO-HNS CHE) and the Gibson‟s Score. A total of 250 potential MD patients who have had their MD-related signs and symptoms documented and ECochG testing completed in the Department of Otolaryngology at Christchurch Hospital were included. A selection of details obtained from both the AAO-HNS CHE and ECochG testing results were examined to allow for an investigation on the function of these methods as a diagnostic tool for MD. The inter-method reliability between ECochG and the two subjective methods for the diagnosis of MD was found to be high. In addition, patients that tested “positive”, regardless of the diagnostic method used, showed a higher correlation among the four key symptoms of MD. These results demonstrate that ECochG is an effective diagnostic tool but should not be used as the sole assessment for the diagnosis of MD. This research provides empirical evidence in support of using ECochG as an effective tool as part of the differential diagnosis of MD

Fifty years of limnology (1969-2019) at Mahoney Lake, British Columbia, Canada

Mahoney Lake is a small, meromictic saline lake in south-central British Columbia noted for its unique layer of purple sulfur bacteria. First examined in 1969, this lake has undergone physical, chemical, biological, and pre-historical research to generate an understanding of how the lake and its biota function have developed through time. Advances in understanding the sulfur transformations and bacterial nutrient cycling over the last fifty years have been prolific, resulting in the description of several new taxa. Mahoney Lake is exceptional in its limnological characteristics and is an ideal site for training future limnologists