433 research outputs found
Gamma Ray Lines from a Universal Extra Dimension
Indirect Dark Matter searches are based on the observation of secondary
particles produced by the annihilation or decay of Dark Matter. Among them,
gamma-rays are perhaps the most promising messengers, as they do not suffer
deflection or absorption on Galactic scales, so their observation would
directly reveal the position and the energy spectrum of the emitting source.
Here, we study the detailed gamma-ray energy spectrum of Kaluza--Klein Dark
Matter in a theory with 5 Universal Extra Dimensions. We focus in particular on
the two body annihilation of Dark Matter particles into a photon and another
particle, which produces monochromatic photons, resulting in a line in the
energy spectrum of gamma rays. Previous calculations in the context of the five
dimensional UED model have computed the line signal from annihilations into
\gamma \gamma, but we extend these results to include \gamma Z and \gamma H
final states. We find that these spectral lines are subdominant compared to the
predicted \gamma \gamma signal, but they would be important as follow-up
signals in the event of the observation of the \gamma \gamma line, in order to
distinguish the 5d UED model from other theoretical scenarios.Comment: 21 pages, 6 figure
Neutron time-of-flight measurements of charged-particle energy loss in inertial confinement fusion plasmas
Neutron spectra from secondary ^{3}H(d,n)α reactions produced by an implosion of a deuterium-gas capsule at the National Ignition Facility have been measured with order-of-magnitude improvements in statistics and resolution over past experiments. These new data and their sensitivity to the energy loss of fast tritons emitted from thermal ^{2}H(d,p)^{3}H reactions enable the first statistically significant investigation of charged-particle stopping via the emitted neutron spectrum. Radiation-hydrodynamic simulations, constrained to match a number of observables from the implosion, were used to predict the neutron spectra while employing two different energy loss models. This analysis represents the first test of stopping models under inertial confinement fusion conditions, covering plasma temperatures of k_{B}T≈1-4 keV and particle densities of n≈(12-2)×10^{24} cm^{-3}. Under these conditions, we find significant deviations of our data from a theory employing classical collisions whereas the theory including quantum diffraction agrees with our data
TeV physics and the Planck scale
Supersymmetry is one of the best motivated possibilities for new physics at
the TeV scale. However, both concrete string constructions and phenomenological
considerations suggest the possibility that the physics at the TeV scale could
be more complicated than the Minimal Supersymmetric Standard Model (MSSM),
e.g., due to extended gauge symmetries, new vector-like supermultiplets with
non-standard SU(2)xU(1) assignments, and extended Higgs sectors. We briefly
comment on some of these possibilities, and discuss in more detail the class of
extensions of the MSSM involving an additional standard model singlet field.
The latter provides a solution to the problem, and allows significant
modifications of the MSSM in the Higgs and neutralino sectors, with important
consequences for collider physics, cold dark matter, and electroweak
baryogenesis.Comment: 17 pages, 5 figures. To appear in New Journal of Physic
Differential allocation of study time: Incomplete compensation for the difficulty of the materials
Melody and pitch processing in five musical savants with congenital blindness
Abstract. We examined absolute-pitch (AP) and short-term musical memory abilities of five musical savants with congenital blindness, seven musicians, and seven non-musicians with good vision and normal intelligence in two experiments. In the first, short-term memory for musical phrases was tested and the savants and musicians performed statistically indistinguishably, both signifi- cantly outperforming the non-musicians and remembering more material from the C major scale sequences than random trials. In the second experiment, participants learnt associations between four pitches and four objects using a non-verbal paradigm. This experiment approximates to testing AP ability. Low statistical power meant the savants were not statistically better than the musicians, although only the savants scored statistically higher than the non-musicians. The results are evidence for a musical module, separate from general intelligence; they also support the anecdotal reporting of AP in musical savants, which is thought to be necessary for the development of musical-savant skill
Consensus recommendations for risk stratification in multiple myeloma: report of the International Myeloma Workshop Consensus Panel 2.
A panel of members of the 2009 International Myeloma Workshop developed guidelines for risk stratification in multiple myeloma. The purpose of risk stratification is not to decide time of therapy but to prognosticate. There is general consensus that risk stratification is applicable to newly diagnosed patients; however, some genetic abnormalities characteristic of poor outcome at diagnosis may suggest poor outcome if only detected at the time of relapse. Thus, in good-risk patients, it is necessary to evaluate for high-risk features at relapse. Although detection of any cytogenetic abnormality is considered to suggest higher-risk disease, the specific abnormalities considered as poor risk are cytogenetically detected chromosomal 13 or 13q deletion, t(4; 14) and del17p, and detection by fluorescence in situ hybridization of t(4; 14), t(14; 16), and del17p. Detection of 13q deletion by fluorescence in situ hybridization only, in absence of other abnormalities, is not considered a high-risk feature. High serum beta(2)-microglobulin level and International Staging System stages II and III, incorporating high beta(2)-microglobulin and low albumin, are considered to predict higher risk disease. There was a consensus that the high-risk features will change in the future, with introduction of other new agents or possibly new combinations. (Blood. 2011; 117(18): 4696-4700
Frequent and specific immunity to the embryonal stem cell–associated antigen SOX2 in patients with monoclonal gammopathy
Specific targets of cellular immunity in human premalignancy are largely unknown. Monoclonal gammopathy of undetermined significance (MGUS) represents a precursor lesion to myeloma (MM). We show that antigenic targets of spontaneous immunity in MGUS differ from MM. MGUS patients frequently mount a humoral and cellular immune response against SOX2, a gene critical for self-renewal in embryonal stem cells. Intranuclear expression of SOX2 marks the clonogenic CD138− compartment in MGUS. SOX2 expression is also detected in a proportion of CD138+ cells in MM patients. However, these patients lack anti-SOX2 immunity. Cellular immunity to SOX2 inhibits the clonogenic growth of MGUS cells in vitro. Detection of anti-SOX2 T cells predicts favorable clinical outcome in patients with asymptomatic plasmaproliferative disorders. Harnessing immunity to antigens expressed by tumor progenitor cells may be critical for prevention and therapy of human cancer
Dark Matter in the MSSM
We have recently examined a large number of points in the parameter space of
the phenomenological MSSM, the 19-dimensional parameter space of the
CP-conserving MSSM with Minimal Flavor Violation. We determined whether each of
these points satisfied existing experimental and theoretical constraints. This
analysis provides insight into general features of the MSSM without reference
to a particular SUSY breaking scenario or any other assumptions at the GUT
scale. This study opens up new possibilities for SUSY phenomenology both in
colliders and in astrophysical experiments. Here we shall discuss the
implications of this analysis relevant to the study of dark matter.Comment: 27 pages, 19 figs; Journal version in NJP issue "Focus on Dark Matter
and Particle Physics". Previous version had 26 pages, 19 figures. Text and
some figures have been update
Dark Matter Annihilation around Intermediate Mass Black Holes: an update
The formation and evolution of Black Holes inevitably affects the
distribution of dark and baryonic matter in the neighborhood of the Black Hole.
These effects may be particularly relevant around Supermassive and Intermediate
Mass Black Holes (IMBHs), the formation of which can lead to large Dark Matter
overdensities, called {\em spikes} and {\em mini-spikes} respectively. Despite
being larger and more dense, spikes evolve at the very centers of galactic
halos, in regions where numerous dynamical effects tend to destroy them.
Mini-spikes may be more likely to survive, and they have been proposed as
worthwhile targets for indirect Dark Matter searches. We review here the
formation scenarios and the prospects for detection of mini-spikes, and we
present new estimates for the abundances of mini-spikes to illustrate the
sensitivity of such predictions to cosmological parameters and uncertainties
regarding the astrophysics of Black Hole formation at high redshift. We also
connect the IMBHs scenario to the recent measurements of cosmic-ray electron
and positron spectra by the PAMELA, ATIC, H.E.S.S., and Fermi collaborations.Comment: 12 pages, 7 figures. Invited contribution to NJP Focus Issue on "Dark
Matter and Particle Physics
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