Penyuluhan Bahaya Penyalahgunaan Napza Bagi Pelajar dan Remaja

Penyalahgunaan NAPZA (Narkotika, Psikotropika, dan Zat-zat Adiktif) merupakan suatu pola perilaku yang bersifat patologik, dan biasanya dilakukan oleh individu yang mempunyai kepribadian rentan atau mempunyai resiko tinggi, dan jika dilakukan dalam jangka waktu tertentu akan menimbulkan gangguan bio-psiko-sosial-spiritual. NAPZA bersifat psikotropika dan psikoaktif yang mempunyai pengaruh terhadap sistem syaraf dan biasanya digunakan sebagai analgetika (pengurang rasa sakit) dan memberikan pengaruh pada aktifitas mental dan perilaku serta digunakan sebagai terapi gangguan psikiatrik pada dunia kedokteran. Secara farmakologik, yang termasuk NAPZA antara lain ganja, morfin, sabu, ekstasi, marijuana, putau, kokain, pil koplo, dan sebagainya. Obat-obatan ini termasuk dalam daftar obat G yang artinya dalam penggunaannya harus disertai dengan kontrol dosis yang sangat ketat oleh dokter. Pelajar (siswi) adalah istilah bagi peserta didik pada jenjang pendidikan menengah pertama dan menengah atas. Siswa adalah komponen dalam sistem pendidikan, yang selanjutnya menjalani proses pendidikan, sehingga menjadi manusia yang berkualitas sesuai dengan tujuan pendidikan nasional. Penyuluhan ini menempatkan pelajar sebagai suatu komponen ditinjau dari pendekatan sosial, dan psikologis

Risk of de‐novo formation of chlormequat and mepiquat in industrial cocoa products assessed by ion chromatography coupled with high‐resolution mass spectrometry

Mepiquat (MQ) and chlormequat (CQ) are two main food contaminants that could be naturally present in various animal and plant foods due to heat treatments. Cocoa and its derivative products seem to be a matrix inclined, for both chemical characteristics and production technologies, to the formation of MQ and CQ. In this study, exploiting the selectivity and sensitivity of IC-HRMS, a new reliable analytical method was developed and validated for MQ and CQ quantification. The LOD of the method was set at 1.9 lg kg 1 for both CQ and MQ, and the linearity was defined from 6.25 to 625 lg kg 1 . Average recoveries, at 2 lg L 1 , were 96.5% and 97.5% for CQ and MQ, respectively, while precision as repeatability (RSDr%) was 2.3% and 5.1% respectively. Subsequently, a laboratory-scale experiment was conducted to assess, for the first time, the actual risk of MQ and CQ formation, confirming in cocoa products the presence of MQ at detectable concentration after 55 min at 180 °C, approximately 8 lg kg 1 for cocoa and 7 lg kg 1 for chips. However, the investigation of a wide variety of commercial cocoa and nuts products has fortunately ruled out the presence of such contaminants at detectable concentration

Fatal cardiac arrest in an adult patient with euthyroid anti-SSA/Ro-positive connective tissue disease: a case report

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Identification of a neutralizing epitope within minor repeat region of Plasmodium falciparum CS protein

Malaria remains a major cause of morbidity and mortality worldwide with 219 million infections and 435,000 deaths predominantly in Africa. The infective Plasmodium sporozoite is the target of a potent humoral immune response that can protect murine, simian and human hosts against challenge by malaria-infected mosquitoes. Early murine studies demonstrated that sporozoites or subunit vaccines based on the sporozoite major surface antigen, the circumsporozoite (CS) protein, elicit antibodies that primarily target the central repeat region of the CS protein. In the current murine studies, using monoclonal antibodies and polyclonal sera obtained following immunization with P. falciparum sporozoites or synthetic repeat peptides, we demonstrate differences in the ability of these antibodies to recognize the major and minor repeats contained in the central repeat region. The biological relevance of these differences in fine specificity was explored using a transgenic P. berghei rodent parasite expressing the P. falciparum CS repeat region. In these in vitro and in vivo studies, we demonstrate that the minor repeat region, comprised of three copies of alternating NANP and NVDP tetramer repeats, contains an epitope recognized by sporozoite-neutralizing antibodies. In contrast, murine monoclonal antibodies specific for the major CS repeats (NANP)n could be isolated from peptide-immunized mice that had limited or no sporozoite-neutralizing activity. These studies highlight the importance of assessing the fine specificity and functions of antirepeat antibodies elicited by P. falciparum CS-based vaccines and suggest that the design of immunogens to increase antibody responses to minor CS repeats may enhance vaccine efficacy

Nano-enabled synthetic biology

Biological systems display a functional diversity, density and efficiency that make them a paradigm for synthetic systems. In natural systems, the cell is the elemental unit and efforts to emulate cells, their components, and organization have relied primarily on the use of bioorganic materials. Impressive advances have been made towards assembling simple genetic systems within cellular scale containers. These biological system assembly efforts are particularly instructive, as we gain command over the directed synthesis and assembly of synthetic nanoscale structures. Advances in nanoscale fabrication, assembly, and characterization are providing the tools and materials for characterizing and emulating the smallest scale features of biology. Further, they are revealing unique physical properties that emerge at the nanoscale. Realizing these properties in useful ways will require attention to the assembly of these nanoscale components. Attention to systems biology principles can lead to the practical development of nanoscale technologies with possible realization of synthetic systems with cell-like complexity. In turn, useful tools for interpreting biological complexity and for interfacing to biological processes will result

Phase I Trial of an Alhydrogel Adjuvanted Hepatitis B Core Virus-Like Particle Containing Epitopes of Plasmodium falciparum Circumsporozoite Protein

The objectives of this non-randomized, non-blinded, dose-escalating Phase I clinical trial were to assess the safety, reactogenicity and immunogenicity of ICC-1132 formulated with Alhydrogel (aluminum hydroxide) in 51 healthy, malaria-naive adults aged 18 to 45 years. ICC-1132 (Malariavax) is a recombinant, virus-like particle malaria vaccine comprised of hepatitis core antigen engineered to express the central repeat regions from Plasmodium falciparum circumsporozoite protein containing an immunodominant B [(NANP)3] epitope, an HLA-restricted CD4 (NANPNVDPNANP) epitope and a universal T cell epitope (T*) (amino acids 326—345, NF54 isolate). We assessed an Alhydrogel (aluminum hydroxide)-adjuvanted vaccine formulation at three ICC-1132 dose levels, each injected intramuscularly (1.0 mL) on study days 0, 56 and 168. A saline vaccine formulation was found to be unstable after prolonged storage and this formulation was subsequently removed from the study. Thirty-two volunteers were followed for one year. Local and systemic adverse clinical events were measured and immune responses to P. falciparum and hepatitis B virus core antigens were determined utilizing the following assays: IgG and IgM ELISA, indirect immunofluorescence against P. falciparum sporozoites, circumsporozoite precipitin (CSP) and transgenic sporozoite neutralization assays. Cellular responses were measured by proliferation and IL-2 assays. Local and systemic reactions were similarly mild and well tolerated between dose cohorts. Depending on the ICC-1132 vaccine concentration, 95 to 100% of volunteers developed antibody responses to the ICC-1132 immunogen and HBc after two injections; however, only 29—75% and 29—63% of volunteers, respectively, developed malaria-specific responses measured by the malaria repeat synthetic peptide ELISA and IFA; 2 of 8 volunteers had positive reactions in the CSP assay. Maximal transgenic sporozoite neutralization assay inhibition was 54%. Forty-seven to seventy-five percent demonstrated T cell proliferation in response to ICC-1132 or to recombinant circumsporozoite protein (rCS) NF-54 isolate. This candidate malaria vaccine was well tolerated, but the vaccine formulation was poorly immunogenic. The vaccine may benefit from a more powerful adjuvant to improve immunogenicity

Dynamics of River Mouth Deposits

Bars and subaqueous levees often form at river mouths due to high sediment availability. Once these deposits emerge and develop into islands, they become important elements of the coastal landscape, hosting rich ecosystems. Sea level rise and sediment starvation are jeopardizing these landforms, motivating a thorough analysis of the mechanisms responsible for their formation and evolution. Here we present recent studies on the dynamics of mouth bars and subaqueous levees. The review encompasses both hydrodynamic and morphological results. We first analyze the hydrodynamics of the water jet exiting a river mouth. We then show how this dynamics coupled to sediment transport leads to the formation of mouth bars and levees. Specifically, we discuss the role of sediment eddy diffusivity and potential vorticity on sediment redistribution and related deposits. The effect of waves, tides, sediment characteristics, and vegetation on river mouth deposits is included in our analysis, thus accounting for the inherent complexity of the coastal environment where these landforms are common. Based on the results presented herein, we discuss in detail how river mouth deposits can be used to build new land or restore deltaic shorelines threatened by erosion

The Basics of Water Waves Theory for Analogue Gravity

This chapter gives an introduction to the connection between the physics of water waves and analogue gravity. Only a basic knowledge of fluid mechanics is assumed as a prerequisite.Comment: 36 pages. Lecture Notes for the IX SIGRAV School on "Analogue Gravity", Como (Italy), May 201