AGN STORM 2. II. Ultraviolet Observations of Mrk 817 with the Cosmic Origins Spectrograph on the Hubble Space Telescope

We present reverberation mapping measurements for the prominent ultraviolet broad emission lines of the active galactic nucleus Mrk 817 using 165 spectra obtained with the Cosmic Origins Spectrograph on the Hubble Space Telescope. Our ultraviolet observations are accompanied by X-ray, optical, and near-infrared observations as part of the AGN Space Telescope and Optical Reverberation Mapping Program 2 (AGN STORM 2). Using the cross-correlation lag analysis method, we find significant correlated variations in the continuum and emission-line light curves. We measure rest-frame delayed responses between the far-ultraviolet continuum at 1180 Å and Lyα λ1215 Å ( 10.4 − 1.4 + 1.6 days), N v λ1240 Å ( 15.5 − 4.8 + 1.0 days), Si iv + ]O iv λ1397 Å ( 8.2 − 1.4 + 1.4 days), C iv λ1549 Å ( 11.8 − 2.8 + 3.0 days), and He ii λ1640 Å ( 9.0 − 1.9 + 4.5 days) using segments of the emission-line profile that are unaffected by absorption and blending, which results in sampling different velocity ranges for each line. However, we find that the emission-line responses to continuum variations are more complex than a simple smoothed, shifted, and scaled version of the continuum light curve. We also measure velocity-resolved lags for the Lyα and C iv emission lines. The lag profile in the blue wing of Lyα is consistent with virial motion, with longer lags dominating at lower velocities, and shorter lags at higher velocities. The C iv lag profile shows the signature of a thick rotating disk, with the shortest lags in the wings, local peaks at ±1500 km s−1, and a local minimum at the line center. The other emission lines are dominated by broad absorption lines and blending with adjacent emission lines. These require detailed models, and will be presented in future work

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

COVID-19 pathogenesis is associated with an exaggerated immune response. However, the specific cellular mediators and inflammatory components driving diverse clinical disease outcomes remain poorly understood. We undertook longitudinal immune profiling on both whole blood and peripheral blood mononuclear cells of hospitalized patients during the peak of the COVID-19 pandemic in the United Kingdom. Here, we report key immune signatures present shortly after hospital admission that were associated with the severity of COVID-19. Immune signatures were related to shifts in neutrophil to T cell ratio, elevated serum IL-6, MCP-1, and IP-10 and modulation of CD14+ monocyte phenotype and function. Modified features of CD14+ monocytes included poor induction of the prostaglandin-producing enzyme, COX-2, and enhanced expression of the cell cycle marker Ki-67. Longitudinal analysis revealed reversion of some immune features back to the healthy median level in patients with a good eventual outcome. These findings identify previously unappreciated alterations in the innate immune compartment of patients with COVID-19 and lend support to the idea that therapeutic strategies targeting release of myeloid cells from bone marrow should be considered in this disease. Moreover, they demonstrate that features of an exaggerated immune response are present early after hospital admission, suggesting that immunomodulating therapies would be most beneficial at early time points

Longitudinal double-spin asymmetry and cross section for inclusive jet production in polarized proton collisions at square root of s = 200 GeV

We report a measurement of the longitudinal double-spin asymmetry A(LL) and the differential cross section for inclusive midrapidity jet production in polarized proton collisions at s=200 GeV. The cross section data cover transverse momenta 5 < p(T)< 50 GeV/c and agree with next-to-leading order perturbative QCD evaluations. The A(LL) data cover 5 < p(T)< 17 GeV/c and disfavor at 98% C.L. maximal positive gluon polarization in the polarized nucleon