Atom Formation Rates Behind Shock Waves in Hydrogen and the Effect of Added Oxygen, July 1965 - July 1966

Formation rate of atomic hydrogen behind shock waves in hydrogen-argon mixture

Energy Wheel Performance and Optimization Opportunities for SDVAV AHU's In a Hot & Humid Climate

The HVAC system accounts for 30 to 50 percent of a typical building's energy consumption; in hot & humid climates it is closer to the upper end of that range. Implementing effective energy saving measures for the building HVAC system can reduce the building energy consumption, reduce peak demand, and improve building comfort. The energy wheel is widely used in new system designs to recover/reject both sensible and latent heat energy from/to the exhaust airflow of air handling units. In this study, field measurements were conducted to evaluate the performance of one energy wheel installed in a SDVAV AHU serving an education building on a large university campus located in a hot and humid area. This paper also presents recommended optimization and performance improvement opportunities associated with this unit based on the performance evaluation

Propofol Sedation for Oesophago-Gastro-Duodenoscopy

A questionnaire was sent to 53 patients who had undergone an upper gastrointestinal endoscopy under total intravenous anaesthesia (TIVA) using intermittent Propofol. All of the patients would accept the same technique again. Out of 20 patients who had previously had the procedure performed under Diazepam sedation, 18 preferred the use of Propofol. This technique can only be used with an anaesthetist present

Exclusive diffractive processes at HERA within the dipole picture

We present a simultaneous analysis, within an impact parameter dependent saturated dipole model, of exclusive diffractive vector meson (J/psi, phi and rho) production, deeply virtual Compton scattering and the total gamma* p cross section data measured at HERA. Various cross sections measured as a function of the kinematic variables Q^2, W and t are well described, with little sensitivity to the details of the vector meson wave functions. We determine the properties of the gluon density in the proton in both longitudinal and transverse dimensions, including the impact parameter dependent saturation scale. The overall success of the description indicates universality of the emerging gluon distribution and proton shape.Comment: 48 pages, 28 figures, the final version to appear in Physical Review

Development of Temperature and Humidity-Based Indicators for Diagnosing Problems in Low Tonnage, Split System Air Conditioners

This paper presents results of a survey of the literature and identifies the most common degraded conditions associated with low-tonnage air conditioners. Other laboratory studies as well as marketed diagnostic systems are also summarized. A procedure for identification of useful, low-cost temperature-based indicators of degraded conditions has been developed at the Energy Systems Laboratory, Texas A&M University in College Station, TX under contract to Honeywell. This paper presents the methodology used to identify the temperature-based indicators for the most common degraded conditions gleaned from the literature

Risk management as a basis for integrated water cycle management in Kazakhstan

Integrated Water Cycle Management (IWCM) aims to bring together a diversity of social, environmental, technological and economic aspects to implement sustainable water and land management systems. This paper investigates the challenges and opportunities facing Kazakhstan as it its efforts to move towards a more sustainable approach to managing its finite and highly stressed water resources. The use of a strategic-level risk governance framework to support a multi-disciplinary Kazakh-EU consortium in working collabora-tively towards enhancing capacity and capability to address identified challenges is described. With a clear focus on addressing capacity building needs, a strong emphasis is placed on developing taught integrated water cycle management programmes through communi-cation, stakeholder engagement and policy development including appropriate tools for managing the water issues including hydraulic models, GIS-based systems and scenario developments. Conclusions on the benefits of implementing an EU-style Water Framework Directive for Central Asia based on a risk management approach in Kazakhstan are formulated

The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries

Recently, we reported the combination of multitargeted ErbB1 inhibitor–DNA damage combi-molecules with OCT in order to downregulate ErbB1 and activate SSTRs. Absence of translation to cell kill was believed to be partially due to insufficient ErbB1 blockage and DNA damage. In this study, we evaluated cell response to molecules that damage DNA more aggressively and induce stronger attenuation of ErbB1 phosphorylation. We used three cell lines expressing low levels (U87MG) or transfected to overexpress wildtype (U87/EGFR) or a variant (U87/EGFRvIII) of ErbB1. The results showed that Iressa ± HN2 and the combi-molecules, ZRBA4 and ZR2003, significantly blocked ErbB1 phosphorylation in U87MG cells. Addition of OCT significantly altered cell cycle distribution. Analysis of the DNA damage response pathway revealed strong upregulation of p53 by HN2 and the combi-molecules. Apoptosis was only induced by a 48 h exposure to HN2. All other treatments resulted in cell necrosis. This is in agreement with Akt-Bad pathway activation and survivin upregulation. Despite strong DNA damaging properties and downregulation of ErbB1 phosphorylation by these molecules, the strongest effect of SSTR activation was on cell cycle distribution. Therefore, any enhanced antiproliferative effects of combining ErbB1 inhibition with SSTR activation must be addressed in the context of cell cycle arrest

Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

Glycogen availability can influence glucose transporter 4 (GLUT4) expression in skeletal muscle through unknown mechanisms. The multisubstrate enzyme AMP-activated protein kinase (AMPK) has also been shown to play an important role in the regulation of GLUT4 expression in skeletal muscle. During contraction, AMPK [alpha]2 translocates to the nucleus and the activity of this AMPK isoform is enhanced when skeletal muscle glycogen is low. In this study, we investigated if decreased pre-exercise muscle glycogen levels and increased AMPK [alpha]2 activity reduced the association of AMPK with glycogen and increased AMPK [alpha]2 translocation to the nucleus and GLUT4 mRNA expression following exercise. Seven males performed 60 min of exercise at ~70% [VO.sub.2] peak on 2 occasions: either with normal (control) or low (LG) carbohydrate pre-exercise muscle glycogen content. Muscle samples were obtained by needle biopsy before and after exercise. Low muscle glycogen was associated with elevated AMPK [alpha]2 activity and acetyl-CoA carboxylase [beta] phosphorylation, increased translocation of AMPK [alpha]2 to the nucleus, and increased GLUT4 mRNA. Transfection of primary human myotubes with a constitutively active AMPK adenovirus also stimulated GLUT4 mRNA, providing direct evidence of a role of AMPK in regulating GLUT4 expression. We suggest that increased activation of AMPK [alpha]2 under conditions of low muscle glycogen enhances AMPK [alpha]2 nuclear translocation and increases GLUT4 mRNA expression in response to exercise in human skeletal muscle. <br /