53,176 research outputs found
Preparation and evaluation of fiber metal nickel battery plaques third quarterly progress report, feb. 1 - apr. 30, 1965
Effect of fiber size opon internal surface area and pore size of nickel fiber metal plaque
The resistible effects of Coulomb interaction on nucleus-vapor phase coexistence
We explore the effects of Coulomb interaction upon the nuclear liquid vapor
phase transition. Because large nuclei (A>60) are metastable objects, phases,
phase coexistence, and phase transitions cannot be defined with any generality
and the analogy to liquid vapor is ill-posed for these heavy systems. However,
it is possible to account for the Coulomb interaction in the decay rates and
obtain the coexistence phase diagram for the corresponding uncharged system.Comment: 5 pages, 5 figure
Entropy-expansiveness for partially hyperbolic diffeomorphisms
We show that diffeomorphisms with a dominated splitting of the form
, where is a nonhyperbolic central bundle that
splits in a dominated way into 1-dimensional subbundles, are entropy-expansive.
In particular, they have a principal symbolic extension and equilibrium states.Comment: 15 pages, 1 figur
Party finance reform as constitutional engineering? The effectiveness and unintended consequences of party finance reform in France and Britain
In both Britain and France, party funding was traditionally characterized by a laissez faire approach and a conspicuous lack of regulation. In France, this was tantamount to a 'legislative vacuum'. In the last two decades, however, both countries have sought to fundamentally reform their political finance regulation regimes. This prompted, in Britain, the Political Parties, Elections and Referendums Act 2000, and in France a bout of 'legislative incontinence' — profoundly transforming the political finance regime between 1988 and 1995. This article seeks to explore and compare the impacts of the reforms in each country in a bid to explain the unintended consequences of the alternative paths taken and the effectiveness of the new party finance regime in each country. It finds that constitutional engineering through party finance reform is a singularly inexact science, largely due to the imperfect nature of information, the limited predictability of cause and effect, and the constraining influence of non-party actors, such as the Constitutional Council in France, and the Electoral Commission in Britain
Robust non-adiabatic molecular dynamics for metals and insulators
We present a new formulation of the correlated electron-ion dynamics (CEID)
scheme, which systematically improves Ehrenfest dynamics by including quantum
fluctuations around the mean-field atomic trajectories. We show that the method
can simulate models of non-adiabatic electronic transitions, and test it
against exact integration of the time-dependent Schroedinger equation. Unlike
previous formulations of CEID, the accuracy of this scheme depends on a single
tunable parameter which sets the level of atomic fluctuations included. The
convergence to the exact dynamics by increasing the tunable parameter is
demonstrated for a model two level system. This algorithm provides a smooth
description of the non-adiabatic electronic transitions which satisfies the
kinematic constraints (energy and momentum conservation) and preserves quantum
coherence. The applicability of this algorithm to more complex atomic systems
is discussed.Comment: 36 pages, 5 figures. Accepted for publication in Journal of Chemical
Physic
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Current and Future Issues in the Development of Spinal Agents for the Management of Pain.
Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal dorsal horn and this output informs the brain as to the peripheral environment. This encoding process is subject to strong upregulation resulting in hyperesthetic states and downregulation reducing the ongoing processing of nociceptive stimuli reversing the hyperesthesia and pain processing. The present review addresses the biology of spinal nociceptive processing as relevant to the effects of intrathecally-delivered drugs in altering pain processing following acute stimulation, tissue inflammation/injury and nerve injury. The review covers i) the major classes of spinal agents currently employed as intrathecal analgesics (opioid agonists, alpha 2 agonists; sodium channel blockers; calcium channel blockers; NMDA blockers; GABA A/B agonists; COX inhibitors; ii) ongoing developments in the pharmacology of spinal therapeutics focusing on less studied agents/targets (cholinesterase inhibition; Adenosine agonists; iii) novel intrathecal targeting methodologies including gene-based approaches (viral vectors, plasmids, interfering RNAs); antisense, and toxins (botulinum toxins; resniferatoxin, substance P Saporin); and iv) issues relevant to intrathecal drug delivery (neuraxial drug distribution), infusate delivery profile, drug dosing, formulation and principals involved in the preclinical evaluation of intrathecal drug safety
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