Affect intensity and affect regulation in prisoners with a history of self-harm

Prisoners with a history of self-harm have reported experiencing more anger (e.g., Hilbrand, Krystal, Sharpe, & Foster, 1994 ), and despair (e.g., Shea, 1993 ), and less ability to cope (e.g., Shea, 1993; Liebling, 1992) than prisoners with no history of self-harm. This suggests that intense negative affective experiences and less control over these states might be pervasive characteristics in individuals vulnerable to self-harm. The present study tested the hypotheses that high affect intensity, the tendency to experience both positive and negative emotional states intensely (Larsen & Diener, 1987), and deficits in negative affect regulation would be associated with self-harm behaviour. Twenty prisoners with a history of self-harm and twenty control prisoners rated emotional responsiveness on a modified version of the Affect Intensity Measure (Larsen & Diener, 1987), and the utility of strategies to decrease intense negative affective states on an affect regulation strategies checklist (ARSC). Prisoners with a history of self-harm reported experiencing significantly more intense- levels of negative affect and less experience of serene states than control prisoners. Positive affect intensity levels did not differ between groups. The self-harm group reported utilising a significantly more varied, but less efficient repertoire of affect regulation strategies. They also rated cognitive strategies significantly lower and aggressive strategies significantly higher. Results suggest that screening prisoners for intense negative emotional responsiveness and dysfunctional affect regulation may facilitate the identification and management of prisoners vulnerable to self-harm. Further research is required to validate the dimensions of the AlM(M) and the ARSC, and explore the mechanisms of intense negative affective experiences and self-harm behaviour

Leading with Marianist Values: Report of the Marianist Leadership Task Force

In the academic climate survey conducted in April, 2014 some respondents indicated they did not believe UD is responding/behaving in ways that are consistent with a Marianist institution. This finding was found in multiple units, leading to several unit leaders proposing to conduct training/education on Marianist administration. Many deans and others had already shared with their leadership teams the Steven Neiheisel paper “Characteristics of Marianist Administration,” and units were trying to draw practical conclusions from the content of that manuscript. Discussion of the document at the Provost Council meeting in December 2014 led to the suggestion that Deb Bickford convene a group of people involved in leadership development touching upon our Marianist charism. Our charge was to develop, if possible, programming guidelines that complement and support work already taking place with MEAs and in Leadership UD and HR. Specifically, we were asked to tease out, and extend more deeply some of the work already taking place, and to identify guiding principles or guidelines for engagement around training supervisors and supervisees on administrative standards fitting for a Marianist institution. We were asked to develop educational opportunities for academic leaders to gain a better understanding of what Marianist Administration would “look like” in everyday practice

Stratified statistical models of North Atlantic basin-wide and regional tropical cyclone counts

Using the historical Atlantic tropical cyclone record, this study examines the empirical relationships between climate state variables and Atlantic tropical cyclone counts. The state variables considered as predictors include indices of the El Niño/Southern Oscillation and Northern Atlantic Oscillation, and both “local” and “relative” measures of Main Development Region sea surface temperature. Other predictors considered include indices measuring the Atlantic Meridional Mode and the West African monsoon. Using all of the potential predictors in a forward stepwise Poisson regression, we examine the relationships between tropical cyclone counts and climate state variables. As a further extension on past studies, both basin-wide named storm counts and cluster analysis time series representing distinct flavors of tropical cyclones, are modeled. A wide variety of cross validation metrics reveal that basin-wide counts or sums over appropriately chosen clusters may be more skillfully modeled than the individual cluster series. Ultimately, the most skillful models typically share three predictors: indices for the main development region sea surface temperatures, the El Niño/Southern Oscillation, and the North Atlantic Oscillation

Alterations in Content and Localization of Defensins in Rat Ileum and Jejunum Following Ischemia-Reperfusion. Specific Peptides, in Specific Places, for Specific Jobs?

Objective: To determine alterations in quantities and distributions of natural antimicrobials following ischemia-reperfusion injury. We hypothesized that these compounds would be upregulated in areas of small intestine where changes in permeability and cellular disruption were likely and where protective mechanisms would be initiated. Methods: Rats with ischemia-reperfusion underwent superior mesenteric artery clamping and reperfusion. Shams were subjected to laparotomy but no clamping. Ileum and jejunum were harvested and sectioned, and subjected to fluorescence deconvolution microscopy for determinations of content and localization of rat beta defensins, 1, 2, 3; rat neutrophil protein-1; and cathelicidin LL-37. Modeling was performed to determine cellular location of antimicrobials. Results: Ischemia-reperfusion increased neutrophil defensin alpha (RNP-1) in jejunum; rat beta defensin 1 was increased 2-fold in ileal mucosa and slightly reduced in jejunal mucosa; rat beta defensin 2 was reduced by ischemia-reperfusion in ileum, but slightly increased in jejunum; rat beta defensin 3 was concentrated in the muscularis externa and myenteric plexus of the jejunum; ischemia-reperfusion did not alter cathelicidin LL-37 content in the small intestine, although a greater concentration was seen in jejunum compared with ileum. Conclusion: Ischemia-reperfusion injury caused changes in antimicrobial content in defined areas, and these different regulations might reflect the specific roles of jejunum versus ileum

Basketball game-related statistics that discriminate between teams season-long success

The aim of the present study was to identify the game-related statistics that discriminate between season-long successful and unsuccessful basketball teams participating in the Spanish Basketball League (LEB1). The sample included all 145 average records per season from the 870 games played between the 2000-2001 and the 2005-2006 regular seasons. The following game-related statistics were gathered from the official box scores of the Spanish Basketball Federation: 2- and 3-point field-goal attempts (both successful and unsuccessful), free-throws (both successful and unsuccessful), defensive and offensive rebounds, assists, steals, turnovers, blocks (both made and received), and fouls (both committed and received). To control for season variability, all results were normalized to minutes played each season and then converted to z-scores. The results allowed discrimination between best and worst teams' performances through the following game-related statistics: assists (SC=0.47), steals (SC=0.34), and blocks (SC=0.30). The function obtained correctly classified 82.4% of the cases. In conclusion, season-long performance may be supported by players' and teams' passing skills and defensive preparation

Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration

The intestinal epithelium is largely maintained by self-renewing stem cells but with apparently committed progenitors also contributing, particularly following tissue damage. However, the mechanism of, and requirement for, progenitor plasticity in mediating pathological response remain unknown. Here we show that phosphorylation of the transcription factor Atoh1 is required for both the contribution of secretory progenitors to the stem cell pool and for a robust regenerative response. As confirmed by lineage tracing, Atoh1+ cells (Atoh1(WT)CreERT2 mice) give rise to multilineage intestinal clones both in the steady state and after tissue damage. In a phosphomutant Atoh1(9S/T-A)CreERT2 line, preventing phosphorylation of ATOH1 protein acts to promote secretory differentiation and inhibit the contribution of progenitors to self-renewal. Following chemical colitis, Atoh1+ cells of Atoh1(9S/T-A)CreERT2 mice have reduced clonogenicity that affects overall regeneration. Progenitor plasticity maintains robust self-renewal in the intestinal epithelium, and the balance between stem and progenitor fate is directly coordinated by ATOH1 multisite phosphorylation

"They're Really PD Today": An Exploration of Mental Health Nursing Students' Perceptions of Developing a Therapeutic Relationship With Patients With a Diagnosis of Antisocial Personality Disorder

The therapeutic relationship is of particular importance when working with patients with antisocial personality disorder, but despite this, there is a paucity of literature exploring student nurses’ perceptions of developing a therapeutic relationship with such patients. Hence, this qualitative study explored the perceptions of second-year mental health nursing students of developing a therapeutic relationship with this patient group. Student nurses from a University in the Northwest of England participated in two focus groups, to compare the perceptions of a group of student nurses who had experience in secure settings (forensic hospital) with those who had not. Four key themes emerged: diagnosis, safety, engagement, and finally environmental influences. Both groups commented on looking beyond the diagnosis and seeing the person. The student nurses cited other staff in their clinical placement areas as hugely influential in terms of the development of their perceptions of patients with antisocial personality disorder and how to relate to them

Roadmap for Computer-Aided Modeling of Theranostics and Related Nanosystems

Detailed understanding of the interactions of novel metal-containing nanoparticles with biological membranes, macromolecules and other molecular targets of the living cell is crucial for the elucidation of the biological actions of such functionalized nanosystems. We present here the construction and modeling of thiolate-protected gold clusters and the prediction of their static and dynamic properties