Influence of Maternal Prior Life Adversity on the Psycho-Neuroendocrine-Immune Profile During Pregnancy

Pregnancy is accompanied by a multitude of physical and psychological changes. Adaptation to these changes through reduced anxiety and attenuated stress responsiveness is necessary across gestation and into the postpartum period for optimal maternal-infant health. In contrast, exposure to higher amounts of stressors during pregnancy can disrupt neuroendocrine-immune processes required for successful pregnancy outcomes. Evolving evidence demonstrates that exposure to adversity early in life has long-lasting effects on stress response systems that alter stress reactivity during adulthood. Given this evidence, it is posited that women who experience greater pre-pregnancy adversity during their childhood are at greater risk for negative maternal-infant health sequelae. Thus, the purpose of this study is to investigate the relationship between maternal childhood adversity and the psychological-neuroendocrine-immune profile during pregnancy. In addition, maternal risk and protective factors posited to moderate this profile were examined. Lastly, the relationship among maternal childhood adversity, maternal PNI profile during pregnancy, and neonatal outcomes were explored. The findings can contribute to improved approaches to identify and stratify risk for adverse maternal-infant health outcomes, as well as guide the development of early intervention programs and health policy for women who are pregnant or who plan to become pregnant. This is significant because the well-being of mothers and infants determines the health of the next generation. Improving maternal-infant well-being can markedly reduce public health challenges and ultimately reduce health care costs across the lifespan (U.S. Department of Health and Human Service, 2011)

Prospective cohort study of the effectiveness of varenicline versus nicotine replacement therapy for smoking cessation in the "real world"

It is important to know the comparative effectiveness of varenicline and nicotine replacement therapy (NRT) for smoking cessation when prescribed under routine circumstances and in the general population. Previous estimates relied on cross-sectional data. The objective of the current study was to use longitudinal data to compare the abstinence rates of smokers trying to stop having used varenicline versus NRT on prescription (Rx) when provided with minimal professional support in the general population while adjusting for key potential confounders

Association between income and education with quit attempts, use of cessation aids, and short-term success in tobacco smokers: A social gradient analysis from a population-based cross-sectional household survey in Germany (DEBRA study)

INTRODUCTION: Smoking is more prevalent in smokers from lower compared with higher socioeconomic (SES) groups, but studies are inconsistent regarding underlying mechanisms. We aimed to assess associations between SES indicators and three distinct aspects of the smoking cessation process: attempting to quit; use of evidence-based cessation treatments; and success. METHODS: We analysed data of 12,161 last-year smokers (i.e., current smokers and recent ex-smokers who quit ≤ 12 months) from 20 waves (June/July 2016 to August/September 2019) of the German Study on Tobacco Use (DEBRA) - a representative household survey. Associations between indicators of SES (income and education) and (1) last-year quit attempts; (2) use of evidence-based cessation treatment or electronic cigarettes during the last attempt; and (3) short-term self-reported abstinence were analysed using multivariable logistic regression, adjusted for potential confounders. RESULTS: Of all last-years smokers, 18.6% had attempted to quit, of whom 15.2% had successfully stopped. Higher income (OR 0.82, 95%CI = 0.77-0.88 per 1000€) but low vs. high education (OR 0.83, 95%CI = 0.73-0.95) were associated with lower odds of quit attempts. In smokers with quit attempts, higher income but not education was associated with higher odds of using cessation medication (OR 1.31, 95%CI = 1.08-1.59 per 1000 €). Neither income nor education were associated with using behavioural support or success. CONCLUSIONS: In the German healthcare system without free access to evidence-based cessation therapy, low-income smokers are more likely to make a quit attempt but less likely to use cessation medication than high-income smokers. Equitable access to such medication is crucial to reduce SES-related health disparities

Alcohol consumption and associations with sociodemographic and health-related characteristics in Germany: a population survey

BACKGROUND: To assess the prevalence of ever-drinking and hazardous drinking among adults in Germany, and investigate the factors associated with level of alcohol consumption. METHODS: Cross-sectional population survey of a representative sample of 11,331 adults in Germany (2018 to 2019). The Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) was used to define ever-drinking (AUDIT-C>=1), hazardous drinking (AUDIT-C>=5) and an overall AUDIT-C (alcohol consumption) score (from 0 to 12). Regression models were used to examine sociodemographic and health-related characteristics associated with AUDIT-C score. RESULTS: The prevalence of ever-drinking and hazardous drinking was 84.7% (95% CI = 84.1–85.4) and 19.4% (95% CI = 18.6–20.1), respectively. The mean AUDIT-C score was 2.8 (SD = 2.16). AUDIT-C scores were independently positively associated with having medium (Badj = 0.12, 95% CI = 0.02–0.21) and high (Badj = 0.11, 95% CI = 0.01–0.21) educational qualifications (compared with low), monthly income (Badj = 0.31 per €1,000, 95% CI = 0.26–0.36), being a current smoker (Badj = 0.94, 95% CI = 0.86–1.02), anxiety (Badj = 0.26, 95% CI = 0.02–0.50), and living in North East (Badj = 0.43, 95% CI = 0.29–0.58), North West (Badj = 0.47, 95% CI = 0.39–0.55) and South East (Badj = 0.79, 95% CI = 0.64–0.93) Germany (compared with South West), and negatively associated with age (Badj = -0.17, 95% CI = -0.21- −0.13), being female (Badj = -1.21, 95% CI = -1.28- −1.14) and depression (Badj = -0.22, 95% CI = -0.43- −0.02). CONCLUSIONS: In a large, representative sample of adults in Germany, the majority were ever-drinkers and one fifth were hazardous drinkers. Higher alcohol consumption scores were associated with being younger, male, current smoker, of high socioeconomic position, anxiety, and not living in South West Germany, and lower scores were associated with depression. These groups may benefit from targeted alcohol reduction policies and support

Apparatus for Securely Configuring A Target Device and Associated Methods

Apparatus and method securely transfer first data from a source device to a target device. A wireless signal having (a) a higher speed channel conveying second data and (b) a lower speed channel conveying the first data is transmitted. The lower speed channel is formed by selectively transmitting the wireless signal from one of a first and second antennae of the source device based upon the first data. The first and second antenna are positioned a fixed distance apart and the target device uses a received signal strength indication (RSSI) of the first signal to decode the lower speed channel and receive the first data

Wanda: securely introducing mobile devices (Extended version)

Nearly every setting is increasingly populated with wireless and mobile devices -- whether appliances in a home, medical devices in a health clinic, sensors in an industrial setting, or devices in an office or school. There are three fundamental operations when bringing a new device into any of these settings: (1) to configure the device to join the wireless local-area network, (2) to partner the device with other nearby devices so they can work together, and (3) to configure the device so it connects to the relevant individual or organizational account in the cloud. The challenge is to accomplish all three goals simply, securely, and consistent with user intent. We present a novel approach we call Wanda -- a `magic wand\u27 that accomplishes all three of the above goals -- and evaluate a prototype implementation. This Tech Report contains supplemental information to our INFOCOM 2016 paper titled, ``Wanda: securely introducing mobile devices.\u27\u27 Much of the additional information is in Section II, III, and VI

Detecting the Presence of Electronic Devices in Smart Homes Using Harmonic Radar

Data about users is collected constantly by phones, cameras, Internet websites, and others. The advent of so-called ‘Smart Things\u27 now enable ever-more sensitive data to be collected inside that most private of spaces: the home. The first step in helping users regain control of their information (inside their home) is to alert them to the presence of potentially unwanted electronics. In this paper, we present a system that could help homeowners (or home dwellers) find electronic devices in their living space. Specifically, we demonstrate the use of harmonic radars (sometimes called nonlinear junction detectors), which have also been used in applications ranging from explosives detection to insect tracking. We adapt this radar technology to detect consumer electronics in a home setting and show that we can indeed accurately detect the presence of even ‘simple’ electronic devices like a smart lightbulb. We evaluate the performance of our radar in both wired and over-the-air transmission scenarios

Demo: Wanda, Securely Introducing Mobile Devices

Nearly every setting is increasingly populated with wireless and mobile devices – whether appliances in a home, medical devices in a health clinic, sensors in an industrial setting, or devices in an office or school. There are three fundamental operations when bringing a new device into any of these settings: (1) to configure the device to join the wireless local-area network, (2) to partner the device with other nearby devices so they can work together, and (3) to configure the device so it connects to the relevant individual or organizational account in the cloud. The challenge is to accomplish all three goals simply, securely, and consistent with user intent. We developed Wanda – a `magic wand\u27 that accomplishes all three of the above goals – and will demonstrate a prototype implementation