Unusual Large Sporadic Angiomyolipoma Co-existing with Huge Simple Renal Cyst

Renal Angiomyolipoma (AML) is an unusual benign mesenchymal tumor with no malignant potential. It is composed of adipose tissue, smooth muscle and abnormal thick walled blood vessels. It can occur sporadically or may be associated with tuberous sclerosis. Sporadic angiomyolipoma (AML) coexisting with simple renal cyst is extremely rare and only one case report is available in the literature. In our case, unique combination of sporadic AML along with simple renal cyst with huge size and weight was noted. To the best of our knowledge, ours is the second such case and first case from India. Due to its large size, complete nephrectomy was performed to avoid chances of rupture and retroperitoneal hemorrhage. Post-operative period was uneventful and the patient ahs been on regular follow-up

Shelter from the storm : the land struggles of bonded labor in India

Meeting: Celebrating Dialogue : An International SAS2 Forum, November 3, 2008, Carleton University, Ottawa, ON, CASAS reports are made available in order to provide timely access to the information by interested researchers. This report has been subject to an internal review process to ensure accuracy and quality

SAS2

SAS reports are made available in order to provide timely access to the information by interested researchers. This report has been subject to an internal review process to ensure accuracy and quality.The paper outlines issues arising in a planning process with a poor tribal group who have no legal title to the land where their homes have been for decades. Families live with the constant fear of eviction, an ever-increasing occurrence in Thane District where land prices are rising rapidly due to proximity to Mumbai. The character of the project was identified and a planning approach and management tool was selected. Six months later, a second assessment was done and project modalities adjusted

SAS2

SAS reports are made available in order to provide timely access to the information by interested researchers. This report has been subject to an internal review process to ensure accuracy and quality.Towards the end of this assessment process, participants decided to present a land petition at the village assembly and with officials of the revenue department, in an attempt to broaden their network of support and draw attention to their rights. The focus of the assessment was neglect of government officials and elected representatives. Participants also recognized that gaps in information and communication related to the Katkari’s legal rights as residents of tribal lands, worsen the situation by keeping from public view illegal advantages held by wealthy landowners. The paper provides a brief overview of this situation

SAS2

SAS reports are made available in order to provide timely access to the information by interested researchers. This report has been subject to an internal review process to ensure accuracy and quality.The Katkari are classified as a Primitive Tribal Group with specific measures for legal protection of their rights, and there are provisions in the Integrated Tribal Development Project (ITDP) to compensate land owners in cases of expropriation of land. This paper provides a rationale, co-created by the villagers, to continue learning about their land rights, and to explore more actively the options for diversifying community livelihoods. The vast majority work as bonded labour on brick-making units in the region, and fear eviction now that land has been sold to a wealthy Mumbai landowner

SAS2

SAS reports are made available in order to provide timely access to the information by interested researchers. This report has been subject to an internal review process to ensure accuracy and quality

Age impairs soluble guanylyl cyclase function in mouse mesenteric arteries

Endothelial dysfunction (ED) comes with age, even without overt vessel damage such as that which occurs in atherosclerosis and diabetic vasculopathy. We hypothesized that aging would affect the downstream signalling of the endothelial nitric oxide (NO) system in the vascular smooth muscle (VSM). With this in mind, resistance mesenteric arteries were isolated from 13-week (juvenile) and 40-week-old (aged) mice and tested under isometric conditions using wire myography. Acetylcholine (ACh)-induced relaxation was reduced in aged as compared to juvenile vessels. Pretreatment with L-NAME, which inhibits nitrix oxide synthases (NOS), decreased ACh-mediated vasorelaxation, whereby differences in vasorelaxation between groups disappeared. Endothelium-independent vasorelaxation by the NO donor sodium nitroprusside (SNP) was similar in both groups; however, SNP bolus application (10(-6) mol L(-1)) as well as soluble guanylyl cyclase (sGC) activation by runcaciguat (10(-6) mol L(-1)) caused faster responses in juvenile vessels. This was accompanied by higher cGMP concentrations and a stronger response to the PDE5 inhibitor sildenafil in juvenile vessels. Mesenteric arteries and aortas did not reveal apparent histological differences between groups (van Gieson staining). The mRNA expression of the α1 and α2 subunits of sGC was lower in aged animals, as was PDE5 mRNA expression. In conclusion, vasorelaxation is compromised at an early age in mice even in the absence of histopathological alterations. Vascular smooth muscle sGC is a key element in aged vessel dysfunction

Oral Insulin

Oral insulin is an exciting area of research and development in the field of diabetology. This brief review covers the various approaches used in the development of oral insulin, and highlights some of the recent data related to novel oral insulin preparation