Torakalna hernijacija kralješnične moždine

Herniation of the spinal cord through a dural defect is a rather rare deformity and very easily misdiagnosed as retromedullary occult intraspinal arachnoid cyst or meningocele. The possible origin of the dural defect can be traumatic, iatrogenic or unknown, so in these cases, congenital with great probability. On the thoracal part of the spinal column it shows a rather characteristic and misleading appearance. The anomaly leads to progressive Brown-Sequard syndrome, and the case history can be extremely long. Surgical repair of the dural defect results in improvement, or even complete recovery, if performed in time. These are the facts that emphasize the importance of early diagnosis.Hernijacija kralježnične moždine kroz duralne defekte prilično je rijetka deformacija koja se vrlo lako pogrešno dijagnosticira kao retromedularna okultna intraspinalna arahnoidna cista ili kao meningokela. Uzrok duralnog defekta može biti traumatski, jatrogeni ili nepoznat, a u ovim je slučajevima vrlo vjerojatno prirođen. Torakalni dio kralježnice pokazuje prilično karakterističan izgled, no koji može zavarati. Poremećaj uzrokuje pojavu progresivnog Brown-Séquardova sindroma, a anamneza može biti izrazito dugotrajna. Ako se provede na vrijeme, kirurško zatvaranje duralnog defekta dovodi do poboljšanja, pa čak i do potpunog oporavka, .to upućuje na važnost rane dijagnoze

Pseudoanguillosporin A and B: Two New Isochromans Isolated from the Endophytic Fungus Pseudoanguillospora sp

Two new isochromans named pseudoanguillosporin A (2a) and B (3), together with the known cephalochromin (1), were isolated from Pseudoanguillospora sp. The C-2 absolute configuration of 2a and 3 was deduced from its CD spectrum by the isochroman helicity rule, supported by TDDFT CD calculations. The absolute configuration of the sec-hydroxyl group of 3 was determined by the Mosher NMR method from the MPA esters of its methylated erivative. The axial chirality of 1 was assigned through exciton analysis of its CD spectrum and confirmed by ZINDO CD calculations. The metabolites showed broad antimicrobial activities

A modified “far-lateral” approach for safe resection of retroodontoid dural cysts

Cystic mass lesions at the ventral craniocervical junction have been described only rarely in the past, however, they have received more attention with improved imaging modalities in recent years. These lesions have been approached by various operative procedures. A modified “far-lateral” approach combined with a C1 hemilaminectomy without fusion was used to safely remove the cyst and decompress the cervical medulla in a 72-year-old woman with cervicooccipital pain and paresthesia in both arms. Following surgery, complete resolution of symptoms was achieved, and no recurrence at 1 year follow-up was detected. A modified “far-lateral” approach offers several advantages when compared with other operation techniques