Sensory integration intervention and the development of the premature infant: A controlled trial

Background. Premature infants are at risk of sensory processing difficulties and developmental delays due to an immature central nervous system and possible episodes of medical instability, discomfort, pain and stress during the first weeks or months after birth.Objective. To investigate the effect of Ayres Sensory Integration (ASI) on the development of premature infants in the first 12 months of life.Methods. A pre-/post-test experimental design was used to randomly divide 24 premature infants from a low socioeconomic setting in Bloemfontein, South Africa, into experimental and control groups after being matched by corrected age and gender. Developmental status was determined with the Bayley III Scales of Infant and Toddler Development, the Test of Sensory Functions in Infants and the Infant/ Toddler Sensory Profile. The experimental group received 10 weeks of ASI intervention.Results. ASI intervention had a positive effect on the sensory processing and development of premature infants, especially in terms of cognitive, language and motor development.Conclusions. ASI intervention at an early age enhances the developmental progress of premature infants

Four-year stability of anthropometric and cardio-metabolic parameters in a prospective cohort of older adults

Aim: To examine the medium-term stability of anthropometric and cardio-metabolic parameters in the general population. Materials & methods: Participants were 5160 men and women from the English Longitudinal Study of Ageing (age ≥50 years) assessed in 2004 and 2008. Anthropometric data included height, weight, BMI and waist circumference. Cardio-metabolic parameters included blood pressure, serum lipids (total cholesterol, HDL, LDL, triglycerides), hemoglobin, fasting glucose, fibrinogen and C-reactive protein. Results: Stability of anthropometric variables was high (all intraclass correlations >0.92), although mean values changed slightly (-0.01 kg weight, +1.33 cm waist). Cardio-metabolic parameters showed more variation: correlations ranged from 0.43 (glucose) to 0.81 (HDL). The majority of participants (71–97%) remained in the same grouping relative to established clinical cut-offs. Conclusion: Over a 4-year period, anthropometric and cardio-metabolic parameters showed good stability. These findings suggest that when no means to obtain more recent data exist, a one-time sample will give a reasonable approximation to average levels over the medium-term, although reliability is reduced

Gender-specific changes in quality of life following cardiovascular disease: a prospective study

Gender-specific changes in Quality of Life (QoL) following cardiovascular disease (CVD) were studied in 208 patients to determine whether gender-related differences in postmorbid QoL result from differences in disease severity, premorbid QoL, or different CVD-related recovery. Premorbid data were available from a community-based survey. Follow-ups were done at 6 weeks, 6 months, and 12 months after diagnosis. Results showed that females had worse QoL at all three postmorbid assessments compared to males. However, multivariate analyses adjusting for premorbid gender differences and disease severity showed no significant gender-related differences for physical and psychologic, functioning. Therefore, gender differences in QoL following CVD mainly result from premorbid differences in QoL, age, comorbidity, and disease severity at the time of diagnosis, and do not appear to be the consequence of gender-specific recovery. However, in clinical practice it is important to acknowledge the poorer QoL of females following CVD. (C) 2002 Elsevier Science. All rights reserve

Evaluation of point-of-care tests for detecting microalbuminuria in diabetic patients

Background: Microalbuminuria, the presence of low levels of albumin in the urine, indicates renal damage and is recognised as a risk factor for the progression of renal and cardiovascular disease. Several international scientific bodies recommend microalbuminuria screening. Point-of-care testing (POCT) of microalbuminuria allows immediate identification of risk, and monitoring of treatment effects. In this study, two POCT instruments were evaluated as microalbuminuria screening methods. Method: Spot urine specimens from diabetic patients were analysed with the quantitative HemoCue® urine albumin analyser (n = 245), and the semiquantitative Clinitek® microalbumin urine dipstick (n = 204). These results were compared to the respective data for laboratory-determined albumin (nephelometry), creatinine (modified Jaffe) and albumin-to-creatinine ratio (ACR). Results: Linear regression analysis demonstrated a good correlation for the HemoCue® urine albumin with the laboratorydetermined albumin concentration (y = 0.8557x + 0.2487y, r = 0.97). The sensitivities for the HemoCue® and Clinitek® POCT systems were 79.6% and 83.8%, and the specificities 97.1% and 93.8% respectively. Positive and negative predictive values for the HemoCue® were 95.6% and 85.8%, and were 88.6% and 91.0% the Clinitek®. The repeatability of both instruments was excellent. Both instruments are easy to use, and more cost-effective than the laboratory methods for albumin and ACR. Conclusion: Both the HemoCue® and the Clinitek® microalbumin POCT systems for albuminuria are easy to use and inexpensive, and are adequately accurate as a screening method. Although the HemoCue® POCT system measures only urine albumin concentration, its sensitivity and specificity compared well with that of the Clinitek® POCT system, which determines the ACR.Keywords: microalbuminuria, point-of-care testing, HemoCue®, Clinitek®, urinary albumin excretio

Accelerations due to impact at heel strike using below-knee prosthesis

The acceleration in the sagittal plane of the prosthetic tube at heel strike in normal walking was measured in five healthy amputees with their definitive below-knee prosthesis, every subject using six different prosthetic feet, wearing sport shoes as well as leather shoes. The experiments were carried out in the rehabilitation centre “Het Roessingh”, Enschede, The Netherlands. \ud \ud Maximum accelerations were extracted from the acceleration-time-signal. Mean acceleration maxima of all subjects were calculated for each foot-shoe combination to eliminate the individual influence of the subjects. In the axial direction the maximal accelerations demonstrate a clear difference among the prosthetic feet and the shoes, while in dorsoventral (tangential) direction the. inter-individual variation in the acceleration extremes dominates the difference between the types of footwear. In comparison with non-amputees the magnitude of the maximal axial acceleration at heel strike does not differ significantly

The contribution of dark-green leafy vegetables to total micronutrient intake of two- to five-year-old children in a rural setting

This study determined the contribution of dark-green leafy vegetables (DGLV) to total micronutrient intake of two- to fiveyear- old children residing in two neighbouring rural villages in KwaZulu-Natal where production and consumption of these vegetables were promoted. A repeated cross-sectional study that included five repeated 24 h dietary recalls per study period was done during February (n=79), May (n=74), August (n=75) and November (n=78) of 2005 by interviewing the caregivers. Consumption of spinach (mostly Swiss chard) and imifino (a collective term for various dark-green leaves) complemented each other, with imifino being consumed mostly during the first and last quarter of the year, and spinach (mostly Swiss chard) during the 3rd quarter. The proportion of children who consumed DGLV during the 5 d recall period ranged from 36% (May survey) to 86% (February survey), and the average number of times that children consumed it ranged from 1.4 (May survey) to 2.2 (February survey). The average portion size consumed was approximately ½ cup (87 ± 56 g for spinach; 87 ± 38 g for imifino). For children consuming DGLV, these vegetables contributed significantly to dietary intake of calcium (21 to 39% of total intake), iron (19 to 39%), vitamin A (42 to 68%) and riboflavin (9 to 22%).In conclusion, DGLV made a significant contribution towards total nutrient intake of the children for several of the micronutrients. This contribution can potentially be increased should these vegetables be consumed more frequently and by a larger proportion of the children.Keywords: dark-green leafy vegetables, dietary intake, micronutrients, children, rural, South Afric

Effect of Juice Turbidity and Yeast Lees Content on Brandy Base Wine and Unmatured Pot-still Brandy Quality

The aims of this project were to identify a suitable grape juice clarification technique for the attainment of the optimal brandy base wine turbidity, to determine the importance of chemical components (volatile components and long-chain fatty acids) in brandy base wine and unmatured pot-still brandy quality, and to study the effect of yeast lees content on quality. Although common industry practice is to use the grape cultivars Colombar(d) and Chenin blanc for the production of brandy base wine, the optimal conditions for Chenin blanc have been defined in this study. The juice clarification treatments applied included no settling, cold settling, whisk, large- and small-scale centrifugation and bentonite. Yeast strain 228 was compared with VIN13, large-scale (L) distillation was compared with small-scale (s) distillation, and the use of no enzyme was compared with the use of pectolytic enzyme. The data for four vintages were compiled and evaluated. Settling with or without pectolytic enzyme, bentonite, small-scale centrifugation and whisk treatments gave clearer Chenin blanc juice, higher concentrations of certain volatile components and long-chain fatty acids, and higher quality brandy base wine and unmatured pot-still brandy. No settling and large-scale centrifugation yielded the most turbid and lowest quality products. There is a definite relationship between treatments, turbidity, concentrations of esters, higher alcohols and acids, and overall brandy base wine and unmatured pot-still brandy quality. The use of yeast strain VIN13 (as opposed to strain 228), in conjunction with an increased yeast lees content of 1.5x that is normally found in brandy base wine, yielded the best quality unmatured pot-still brandy. Based on the results of this study, it is possible to recommend the best juice clarification method(s) for optimal turbidity as well as optimal levels of yeast lees addition, and to identify chemical compounds that positively relate to quality

Total β-carotene content of orange sweetpotato cultivated under optimal conditions and at a rural village

At community level, sweetpotato is often cultivated in marginal soils, with low agricultural inputs and is harvested when needed. Total β-carotene content of orange sweetpotato harvested four, five and six months after planting at optimal cultivation conditions and at a rural village was determined. Compared to those produced under optimal conditions, sweetpotato produced under rural village conditions were smaller, had higher β-carotene content and required a smaller serving size to provide 100% of the dietary vitamin A requirements. Harvesting at four, five and six months after planting at a rural village showed gradual increases in β-carotene content; no change was observed under optimal conditions. Differences in β-carotene content due to harvesting time and management level should be considered in food-based interventions addressing vitamin A deficiency.Keywords: Provitamin A content, orange sweet potato, cultivation conditionsAfrican Journal of Biotechnology Vol. 12(25), pp. 3947-395

Metal Concentrations in Grape Spirits

Metals are a necessity for human health as they play significant roles in biological systems. However,contamination of food and beverages by heavy metals such as lead (Pb), iron (Fe), chromium (Cr), cadmium(Cd), copper (Cu), cobalt (Co), Nickel (Ni) and zinc (Zn) is a major public health problem in developingcountries. In this study we evaluated the levels of Li, Be, B, Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Sr,Mo, Cd, Sb, Ba, Hg and Pb in grape spirits, including pot still spirit, neutral wine spirit and commercialbrandies. Interesting variations in the levels of metals was observed. Factors such as origin and type ofspirits influenced levels of metals in spirits. These differences in some metal levels such as copper canbe used to determine possible adulteration and in authenticity assessments of brandies. Surprisingly thecommercial brandies had higher metal concentrations when compared to pot still spirit and neutral winespirit. Unmatured pot still spirit had the highest copper levels. Our study shows that generally the metallevels in most of the commercial brandies were within permissible limits

Simultaneous optimization of speed and buffer times for robust transportation systems

Transport companies often have a published timetable. To maintain timetable reliability despite delays, companies include buffer times during timetable development, and adjust the traveling speed during timetable execution. We develop an approach that can integrate decisions at different time scales (tactical and operational). We model execution of the timetable as a stochastic dynamic program (SDP). An SDP is a natural framework to model random events causing (additional) delay, propagation of delays, and real-time speed adjustments. However, SDPs alone cannot incorporate the buffer allocation, as buffer allocation requires to choose the same action in different states of the SDP. Our objective is finding the buffer allocation that yields the SDP which has minimal long run average costs. We derive several analytical insights into the model. We prove tha