Improvements in ERBS attitude determination without gyros

Previous papers have described the modification of the Earth Radiation Budget Satellite (ERBS) Attitude Determination System (ADS) to overcome the impact of on board gyro degradation and failure on attitude ground support of the mission. Two approaches were taken: implementing a Kalman filter in place of the batch-least-squares attitude estimator to account for the propagation error produced by high-noise gyro data, and modeling the ERBS attitude dynamics to restore rate information in the case of gyro failure. Both of these methods had shortcomings. In practice, the filter attitude diverged without complete sensor observability, and accurate dynamics modeling required knowledge of disturbance torque parameters that had to be determined manually. These difficulties have been overcome by improved tuning of the filter and by incorporating dynamics parameter estimation into the ERBS ADS

1943-09-08, Harold to Frances

https://digitalcommons.chapman.edu/hjglickman_collection/1001/thumbnail.jp

Photograph

https://digitalcommons.chapman.edu/hjglickman_collection/1005/thumbnail.jp

Photograph

https://digitalcommons.chapman.edu/hjglickman_collection/1004/thumbnail.jp

1943-12-02, Harold to Frances

https://digitalcommons.chapman.edu/hjglickman_collection/1002/thumbnail.jp

1943-08-09, Harold to Frances

https://digitalcommons.chapman.edu/hjglickman_collection/1000/thumbnail.jp

1943-12-12, Harold to Frances

https://digitalcommons.chapman.edu/hjglickman_collection/1003/thumbnail.jp

Molecular Dynamics Simulation of Ga Penetration along Grain Boundaries in Al: a Dislocation Climb Mechanism

Many systems where a liquid metal is in contact with a polycrystalline solid exhibit deep liquid grooves where the grain boundary meets the solid-liquid interface. For example, liquid Ga quickly penetrates deep into grain boundaries in Al, leading to intergranular fracture under very small stresses. We report on a series of molecular dynamics simulations of liquid Ga in contact with an Al bicrystal. We identify the mechanism for liquid metal embrittlement, develop a new model for it, and show that is in excellent agreement with both simulation and experimental data

A core genetic module : the Mixed Feedback Loop

The so-called Mixed Feedback Loop (MFL) is a small two-gene network where protein A regulates the transcription of protein B and the two proteins form a heterodimer. It has been found to be statistically over-represented in statistical analyses of gene and protein interaction databases and to lie at the core of several computer-generated genetic networks. Here, we propose and mathematically study a model of the MFL and show that, by itself, it can serve both as a bistable switch and as a clock (an oscillator) depending on kinetic parameters. The MFL phase diagram as well as a detailed description of the nonlinear oscillation regime are presented and some biological examples are discussed. The results emphasize the role of protein interactions in the function of genetic modules and the usefulness of modelling RNA dynamics explicitly.Comment: To be published in Physical Review

Endogenous Gonadal Hormone Exposure and Bone Sarcoma Risk

Although experimental and clinical evidence suggest that endogenous sex hormones influence bone sarcoma genesis, the hypothesis has not been adequately tested in an appropriate animal model. We conducted a historical cohort study of Rottweiler dogs because they frequently undergo elective gonadectomy and spontaneously develop appendicular bone sarcomas, which mimic the biological behavior of the osteosarcomas that affect children and adolescents. Data were collected by questionnaire from owners of 683 Rottweiler dogs living in North America. To determine whether there was an association between endogenous sex hormones and risk of bone sarcoma, relative risk (RR) of incidence rates and hazard ratios for bone sarcoma were calculated for dogs subdivided on the basis of lifetime gonadal hormone exposure. Bone sarcoma was diagnosed in 12.6% of dogs in this cohort during 71,004 dog-months follow-up. Risk for bone sarcoma was significantly influenced by age at gonadectomy. Male and female dogs that underwent gonadectomy before 1 year of age had an approximate one in four lifetime risk for bone sarcoma and were significantly more likely to develop bone sarcoma than dogs that were sexually intact [RR ±95% CI = 3.8 (1.5–9.2) for males; RR ±95% CI = 3.1 (1.1–8.3) for females]. χ2 test for trend showed a highly significant inverse dose-response relationship between duration of lifetime gonadal exposure and incidence rate of bone sarcoma (P = 0.008 for males, P = 0.006 for females). This association was independent of adult height or body weight. We conclude that the subset of Rottweiler dogs that undergo early gonadectomy represent a unique, highly accessible target population to further study the gene:environment interactions that determine bone sarcoma risk and to test whether interventions can inhibit the spontaneous development of bone sarcoma