55 research outputs found

    Enhanced c-myc gene expression during forelimb regenerative outgrowth in the young Xenopus laevis.

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    Investigating the harmonization of highly noisy heterogeneous datasets hand-collected over the same study domain

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    International audienceThe objective of this paper is to propose an approach to harmonise noisy spatial data acquired by different operators using (low-cost) hand-held sensors over the same spatial domain. In such cases, datasets need to be harmonised first to be comparable before decision making. This work proposes a methodology to address this issue in the case of nested and noisy spatial data. First, it proposes the implementation of a non-parametric test of Kolmogorov-Smirnov to determine if harmonisation is needed. Then, it proposes an aspatial harmonization method based on standardization. The method was applied on grape sugar content datasets collected by 2 hand-held spectrometers. Results showed that harmonizing a less confident dataset is interesting solely if the size of the trusted one is too small

    Evidence of altered fertility in female roach (Rutilus rutilus) from the River Seine (France)

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    A large variety of anthropogenic chemicals present in the aquatic environment have been shown to be able to alter the endocrine system of exposed organisms, potentially impacting their reproductive function. The aim of this study was to assess the effects of environmental pollution on the reproductive system of wild female roach (Rutilus rutilus) from the Seine River (Normandy, France). A suite of biomarkers of endocrine disruption including gonado-somatic index, plasmatic vitellogenin, gonadal aromatase activity and histological parameters (oocyte diameter and gonad maturation) were studied. Female fish from the polluted sites showed a number of reproductive alterations, including inhibited gonad maturation, reduced oocyte growth, reduced levels of plasmatic vitellogenin and 3-fold lower gonadal aromatase activity than females collected in the reference site. Overall, these results highlight the presence of endocrine disruption in female roach from the Seine River. © 2014 Elsevier Ltd. All rights reserved

    A flexible floating-point format for optimizing data-paths and operators in FPGA based DSPs

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    A flexible floating-point format for optimizing data-paths and operators in FPGA based DSPs

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    Video signal processing requires complex algorithms performing many basic operations on a video stream. To perform these calculations in real-time in a FPGA, we must use innovative structures to meet speed requirements while managing complexity. As part of a project aiming at the development of a video noise reducer, we developed an optimized processing stream that required some floating-point calculations. This paper presents the rationale for developing a floating-point unit, justifies the data representation used, its implementation in a Xilinx VirtexE FPGA and reports the performance we obtained. A divider using this representation is also presented, with its implementation and performances in the same FPGA

    CYP19A and B gene expression and activity in roach (Rutilus rutilus)

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    Estrogens are steroid hormones involved in the control of important reproduction-related processes including sexual differentiation and maturation. Careful spatial and temporal balance of estrogens in the body is crucial for proper functioning. At the final step of estrogen biosynthesis, cytochrome P450 aromatase, encoded by the cyp19 gene, converts androgens into estrogens. Modulation of aromatase CYP19 expression and function can dramatically alter the rate of estrogen production, disturbing the local and systemic levels of estrogens. This activity has been shown to be sensitive to many endocrine disruptive compounds (EDC) released in the environment and thus could be used as a biomarker to screen for EDC effects. Teleosts are becoming increasingly important indicators of environmental health, and roach, Rutilus rutilus, was suggested as a sensitive model organism to assess the impact of xenobiotic in freshwater. A study has been undertaken to characterise both gene expression and activity of aromatase in the brain and gonad. Subsequently, seasonal variations, incidence of physical factors, biological factors (sex, age), presence of chemicals and association with pathological features (parasites, intersex) have been studied
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