Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression

Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited. Despite the growing number of studies linking the disease with altered serum metabolite levels, an obstacle to the development of metabolome-based NAFLD predictors has been the lack of large cohort data from biopsy-proven patients matched for key metabolic features such as obesity. We studied 467 biopsied individuals with normal liver histology (n=90) or diagnosed with NAFLD (steatosis, n=246; NASH, n=131), randomly divided into estimation (80% of all patients) and validation (20% of all patients) groups. Qualitative determinations of 540 serum metabolite variables were performed using ultra-performance liquid chromatography coupled to mass spectrometry (UPLCMS). The metabolic profile was dependent on patient body-mass index (BMI), suggesting that the NAFLD pathogenesis mechanism may be quite different depending on an individual’s level of obesity. A BMI-stratified multivariate model based on the NAFLD serum metabolic profile was used to separate patients with and without NASH. The area under the receiver operating characteristic curve was 0.87 in the estimation and 0.85 in the validation group. The cutoff (0.54) corresponding to maximum average diagnostic accuracy (0.82) predicted NASH with a sensitivity of 0.71 and a specificity of 0.92 (negative/positive predictive values = 0.82/0.84). The present data, indicating that a BMI-dependent serum metabolic profile may be able to reliably distinguish NASH from steatosis patients, have significant implications for the development of NASH biomarkers and potential novel targets for therapeutic intervention

Curved dilatonic brane-worlds and the cosmological constant problem

We construct a model for dilatonic brane worlds with constant curvature on the brane, i.e. a non-zero four-dimensional cosmological constant, given in function of the dilaton coupling and the cosmological constant of the bulk. We compare this family of solutions to other known dilatonic domain wall solutions and apply a self-tunning mechanism to check the stability of our solutions under quantum fluctuations living on the brane.Comment: latex, 6 pages. (v2): considerable changes in the conclusion. (v3): added new discussion on the solutions and some references; version to appear in CQ

From transpressional to transtensional tectonics in Northern Central America

The Central American Volcanic Arc (CAVA) is located at the western margin of the Caribbean plate, over the Chortís Block, spanning from Guatemala to Costa Rica. The CAVA is associated to the subduction of the Cocos plate under the Caribbean plate at the Middle America Trench. Our study is focused in the Salvadorian CAVA segment, which is tectonically characterized by the presence of the El Salvador Fault Zone (ESFZ), part of the western boundary of a major block forming the Caribbean plate (the Chortis Block). The structural evolution of the western boundary of the Chortis Block, particularly in the CAVA crossing El Salvador remains unknown. We have done a kinematic analysis from seismic and fault slip data and combined our results with a review of regional previous studies. This approach allowed us to constrain the tectonic evolution and the forces that control the deformation in northern Central America. Along the active volcanic arc we identified active transtensional deformation. On the other hand, we have identified two deformation phases in the back arc region: A first one of transpressional wrenching close to simple shearing (Miocene); and a second one characterized by almost E-W extension. Our results reveal a change from transpressional to transtensional shearing coeval with a migration of the volcanism towards the trench in Late Miocene times. This strain change could be related with a coupled to decoupled transition on the Cocos – Caribbean subduction interface, which could be related to a slab roll-back of the Cocos Plate beneath the Chortis Block. The combination of different degrees of coupling on the subduction interface, together with a constant relative eastward drift of the Caribbean Plate, control the deformation style along the western boundary of the Chortis Block

Exploring Software Engineering Subjects by Using Visual Learning Analytics Techniques

[EN]The application of the Information and Communication Technologies to teaching and learning processes is linked to the development of new tools and services that can help students and teachers. Learning platforms are a clear example of this. They are very popular tools in eLearning contexts and provide different kinds of learning applications and services. In addition, these environments also register most of the interactions between the learning process stakeholders and the system. This information could potentially be used to make decisions but usually it is stored as raw data, which is very difficult to understand. This work presents a system that employs visual learning analytic techniques to facilitate the exploitation of that information. The system presented includes several tools that make possible to explore issues such as: when interaction is carried out, which contents are the most important for users, how they interact with others, etc. The system was tested in the context of a software engineering subject, taking into account the stored logs of five academic years. From this analysis it is possible to see how visual analytics can help decision-making and in this context how it helps to improve educational processes

The globular cluster system of the nearest Seyfert II galaxy Circinus

Context. The globular cluster (GC) system of Circinus galaxy has not been probed previously partly because of the location of the galaxy at - 3.8$^\circ$ Galactic latitude which suffers severely from interstellar extinction, stellar crowding, and Galactic foreground contamination. However, the deep near-infrared (NIR) photometry by the VISTA Variables in the Via L\'actea Extended Survey (VVVX) in combination with the precise astrometry of Gaia EDR3 allow us to map GCs in this region. Aims. Our long-term goal is to study and characterise the distributions of GCs and Ultra-compact dwarfs of Circinus galaxy which is the nearest Seyfert II galaxy. Here we conduct the first pilot search for GCs in this galaxy. Methods. We use NIR VVVX photometry in combination with Gaia EDR3 astrometric features such as astrometric excess noise and BP/RP excess factor to build the first homogeneous catalogue of GCs in Circinus galaxy. A robust combination of selection criteria allows us to effectively clean interlopers from our sample. Results. We report the detection of$\sim$ 70 GC candidates in this galaxy at a 3 $\sigma$ confidence level. They show a bimodal colour distribution with the blue peak at (G-Ks)$_0$ = 0.985$\pm$0.127 mag with a dispersion of 0.211$\pm$0.091 mag and the red peak at (G-Ks)$_0$ = 1.625$\pm$0.177 mag with a dispersion of 0.482$\pm$0.114 mag. A GC specific frequency (S$_N$) of 1.3$\pm$0.2 was derived for the galaxy, and we estimated a total population of 120$\pm$40 GCs. Based on the projected radial distribution it appears that Circinus has a different distribution of GC candidates than MW and M31. Conclusions. We demonstrate that Circinus galaxy hosts a sizeable number of cluster candidates. This result is the first leap towards understanding the evolution of old stellar clusters in this galaxy.Comment: 15 pages, 12 figure

Assessment of natural ventilation strategy to decrease the risk of COVID 19 infection at a rural elementary school

Natural ventilation in low-budget elementary schools is the main focus to ensure the health and comfort of its occupants, specifically when looking at the global pandemic related to SARS-COV-2. This paper presents an experimental and novel study of natural ventilation in a public elementary school (Los Zumacales), with a particularly low economic budget. The study was carried out during the winter months of the Covid 19 pandemic. The school is located in the rural area of Castilla y León (North-Western Spain) far from high traffic roads. In this study, a methodology of measuring CO2 concentration was applied in nine classrooms in a school. The experimental study shows the level of natural ventilation in each classroom, expressed in Air Changes per Hour (ACH), using the Decay CO2 concentration method. The method is proven by comparing the experimental values of the obtained ACH with those determined by the most powerful methods to achieve appropriate ventilation levels. Thus, ensuring health protection protocol in rural schools, against the COVID 19 pandemic. Harvard guide and Spanish regulations (RITE), two widely recognized methods have been used together with the experimentally obtained standard by Rey et al. Only one classroom showed a value lower than 3 indicating poor ventilation. In this study, the degree of thermal comfort in the nine classrooms were also analyzed according to the EN15251 standard. An average indoor temperature of approximately 19 °C was obtained, and the relative humidity was stable and correct according to Spanish regulations. In addition, the risk of infection in each classroom was estimated following the international method recommended by the federation of European Heating, Ventilation, and Air Conditioning Associations (REHVA). The probability of infection in all the cases studied was less than 14%.Funding for open access charge: Universidad de Málaga/CBU

Origin of slow magnetic relaxation in Kramers ions with non-uniaxial anisotropy

Transition metal ions with long-lived spin states represent minimum size magnetic bits. Magnetic memory has often been associated with the combination of high spin and strong uniaxial magnetic anisotropy. Yet, slow magnetic relaxation has also been observed in some Kramers ions with dominant easy-plane magnetic anisotropy, albeit only under an external magnetic field. Here we study the spin dynamics of cobalt(II) ions in a model molecular complex. We show, by means of quantitative first-principles calculations, that the slow relaxation in this and other similar systems is a general consequence of time-reversal symmetry that hinders direct spin–phonon processes regardless of the sign of the magnetic anisotropy. Its magnetic field dependence is a subtle manifestation of electronuclear spin entanglement, which opens relaxation channels that would otherwise be forbidden but, at the same time, masks the relaxation phenomenon at zero field. These results provide a promising strategy to synthesize atom-size magnetic memories