21 research outputs found
An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice
Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI
Experimental traumatic brain injury
Traumatic brain injury, a leading cause of death and disability, is a result of an outside force causing mechanical disruption of brain tissue and delayed pathogenic events which collectively exacerbate the injury. These pathogenic injury processes are poorly understood and accordingly no effective neuroprotective treatment is available so far. Experimental models are essential for further clarification of the highly complex pathology of traumatic brain injury towards the development of novel treatments. Among the rodent models of traumatic brain injury the most commonly used are the weight-drop, the fluid percussion, and the cortical contusion injury models. As the entire spectrum of events that might occur in traumatic brain injury cannot be covered by one single rodent model, the design and choice of a specific model represents a major challenge for neuroscientists. This review summarizes and evaluates the strengths and weaknesses of the currently available rodent models for traumatic brain injury
Zeitlicher Verlauf der Gewebeoxygenierung (pTiO2) nach experimeteller Subarachnoidalblutung bei Ratten
Magnesiumsulfat in der Behandlung aneurysmatischer Subarachnoidalblutungen - eine randomisierte Studie
Correlation of brain edema and perfusion deficit in the acute phase after experimental subarachnoid hemorrhage
General view of Carrick's transport, DDB1 in rear, photographed October 1963