856 research outputs found
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Pollinator limitation causes sexual reproductive failure in ex situ populations of self-compatible Iris ensata
Identification of Free and Bound Exciton States and Their Phase-Dependent Trapping Behavior in Lead Halide Perovskites
In this work we probe the sub-gap energy states within polycrystalline and
single crystal lead halide perovskites to better understand their intrinsic
photophysics behaviors. Through combined temperature and intensity-dependent
optical measurements, we reveal the existence of both free and bound exciton
contributions within the sub-gap energy state manifold. The trapping and
recombination dynamics of these excitons is shown to be strongly dependent on
the structural phase of the perovskite. The orthorhombic phase exhibits
ultrafast exciton trapping and distinct trap emission, while the tetragonal
phase gives low monomolecular recombination velocity and capture cross-sections
(~10-18 cm2). Within the multiphonon transition scenario, this suppression in
charge trapping is caused by the increase in the charge capture activation
energy due to the reduction in electron-lattice interactions, which can be the
origin for the unexpected long carrier lifetime in these material systems.Comment: 5 figure
Expression-Based Genome-Wide Association Study Links Vitamin D-Binding Protein With Autoantigenicity in Type 1 Diabetes.
Type 1 diabetes (T1D) is caused by autoreactive T cells that recognize pancreatic islet antigens and destroy insulin-producing β-cells. This attack results from a breakdown in tolerance for self-antigens, which is controlled by ectopic antigen expression in the thymus and pancreatic lymph nodes (PLNs). The autoantigens known to be involved include a set of islet proteins, such as insulin, GAD65, IA-2, and ZnT8. In an attempt to identify additional antigenic proteins, we performed an expression-based genome-wide association study using microarray data from 118 arrays of the thymus and PLNs of T1D mice. We ranked all 16,089 protein-coding genes by the likelihood of finding repeated differential expression and the degree of tissue specificity for pancreatic islets. The top autoantigen candidate was vitamin D-binding protein (VDBP). T-cell proliferation assays showed stronger T-cell reactivity to VDBP compared with control stimulations. Higher levels and frequencies of serum anti-VDBP autoantibodies (VDBP-Abs) were identified in patients with T1D (n = 331) than in healthy control subjects (n = 77). Serum vitamin D levels were negatively correlated with VDBP-Ab levels in patients in whom T1D developed during the winter. Immunohistochemical localization revealed that VDBP was specifically expressed in α-cells of pancreatic islets. We propose that VDBP could be an autoantigen in T1D
Facile synthesis of metal-organic framework films via in situ seeding of nanoparticles
A facile in situ nanoparticle seeding method is reported to prepare MIL-101(Cr) films on alumina supports. The in situ seeding of MIL-101(Cr) nanoparticles was promoted by use of dimethylacetamide (DMA). The generality of this approach is further demonstrated for Cu 3(btc) 2 films by using a (poly)acrylate promoter
Linkage Between SecA Dimerization and Ligand Binding
Abstract. Introduction and Objectives:. There have, yet, been only few attempts to phonetically characterize the vocalizations of pain, although there is wide agreement that moaning, groaning, or other nonverbal utterance can be indicative of pain. We studied the production of vowels “u,” “a,” “i”, and “schwa” (central vowel, sounding like a darker “e” as in hesitations like “ehm”)—as experimental approximations to natural vocalizations.
Methods:. In 50 students vowel production and self-report ratings were assessed during painful and nonpainful heat stimulation (hot water immersion) as well as during baseline (no-stimulation). The phonetic parameters extracted were pitch (mean F0), phonatory fluctuations (range F0) and loudness (acoustic energy level).
Results:. Only for the vowels “u” and “schwa,” which might be considered best approximations to moaning and groaning, did pitch and loudness increase during pain. Furthermore, changes from nonpainful to painful stimulations in these parameters also significantly predicted concurrent changes in pain ratings.
Conclusion:. Vocalization characteristics of pain seem to be best described by an increase in pitch and in loudness. Future studies using more specific and comprehensive phonetic analyses will surely help to provide an even more precise characterization of vocalizations because of pain
The interplay between non-esterified fatty acids and plasma zinc and its influence on thrombotic risk in obesity and type 2 diabetes
This work is funded by the British Heart Foundation (grant numbers: FS/20/3/34956 and FS/19/69/34639), the China Scholarship Council and the Leverhulme Trust (grant number: RPG-2017-214).Thrombosis is a major comorbidity of obesity and type-2 diabetes mellitus (T2DM). Despite the development of numerous effective treatments and preventative strategies to address thrombotic disease in such individuals, the incidence of thrombotic complications remains high. This suggests that not all the pathophysiological mechanisms underlying these events have been identified or targeted. Non-esterified fatty acids (NEFAs) are increasingly regarded as a nexus between obesity, insulin resistance and vascular disease. Notably, plasma NEFA levels are consistently elevated in obesity and T2DM and may impact haemostasis in several ways. A potentially unrecognised route of NEFA-mediated thrombotic activity is their ability to disturb Zn2+ speciation in the plasma. Zn2+ is a potent regulator of coagulation and its availability in the plasma is monitored carefully through buffering by human serum albumin (HSA). The binding of long-chain NEFAs such as palmitate and stearate however trigger a conformational change in HSA that reduce its ability to bind Zn2+ thus increasing the ion’s availability to bind and activate coagulation proteins. NE-FA-mediated perturbation of HSA-Zn2+ binding is thus predicted to contribute to the prothrom-botic milieu in obesity and T2DM, representing a novel targetable disease mechanism in these disorders.Publisher PDFPeer reviewe
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Recent changes to Arctic river discharge
Arctic rivers drain ~15% of the global land surface and significantly influence local communities and economies, freshwater and marine ecosystems, and global climate. However, trusted and public knowledge of pan-Arctic rivers is inadequate, especially for small rivers and across Eurasia, inhibiting understanding of the Arctic response to climate change. Here, we calculate daily streamflow in 486,493 pan-Arctic river reaches from 1984-2018 by assimilating 9.18 million river discharge estimates made from 155,710 satellite images into hydrologic model simulations. We reveal larger and more heterogenous total water export (3-17% greater) and water export acceleration (factor of 1.2-3.3 larger) than previously reported, with substantial differences across basins, ecoregions, stream orders, human regulation, and permafrost regimes. We also find significant changes in the spring freshet and summer stream intermittency. Ultimately, our results represent an updated, publicly available, and more accurate daily understanding of Arctic rivers uniquely enabled by recent advances in hydrologic modeling and remote sensing
High aldosterone, hypertension and adrenal adenoma in a 36-year-old pregnant patient: Is this primary aldosteronism?
A 36-year-old woman presented at 16 weeks’ gestation with severe hypertension. In comparison to the non-pregnant reference normal ranges, potassium was 3.1-3.9 mmol/L, aldosterone 2570-3000 pmol/L (N 250-2885) renin was unsuppressed (24-76.4 ng/L (N1.7–23.9)), with aldosterone to renin ratios in the reference range. An adrenal MRI scan demonstrated a 1.8 × 1.4 cm left adrenal adenoma. Primary aldosteronism was strongly suspected and surgery considered. However, she was managed conservatively with labetalol and modified-release nifedipine with no obstetric complications. Post-partum blood pressures remained elevated with normal aldosterone (539 pmol/L), unsuppressed renin (5.2 ng/L) and normal aldosterone-to-renin ratio (104 (N \u3c 144)). Suspected primary hyperaldosteronism is challenging to investigate and manage in pregnancy. The accepted screening and confirmatory tests are either contraindicated or not validated in pregnancy. Pregnancy has significant effects on the renin-angiotensin-aldosterone pathway leading to physiologic elevations in both aldosterone and renin. While primary hyperaldosteronism has been associated with poor pregnancy outcomes, optimal management in pregnancy is not clearly established
Eckhaus Instability in Laser Cavities with Harmonically Swept Filters
This work was supported in part by National Key R&D Program of China (2019YFB1803904), in part by Science, Technology and Innovation Commission of Shenzhen Municipality (SGDX2019081623060558), in part by Research Grants Council, University Grants Committee of Hong Kong SAR (PolyU152241/18E), and in part by Guangdong Basic and Applied Basic Research Foundation (2021A1515012544) (Corresponding author: Dongmei Huang).Peer reviewedPostprin
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High-Dose Rate Brachytherapy Boost for T3 Prostate Cancer Patients: A Single Institution Experience
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