Repetition and difference: Lefebvre, Le Corbusier and modernity's (im)moral landscape: a commentary

This article engages with the relationship between social theory, architectural theory and material culture. The article is a reply to an article in a previous volume of the journal in question (Smith, M. (2001) ‘Repetition and difference: Lefebvre, Le Corbusier and modernity’s (im)moral landscape’, Ethics, Place and Environment, 4(1), 31-34) and, consequently, is also a direct engagement with another academic's scholarship. It represents a critique of their work as well as a recasting of their ideas, arguing that the matter in question went beyond interpretative issues to a direct critique of another author's scholarship on both Le Corbusier and Lefebvre. A reply to my article from the author of the original article was carried in a later issue of the journal (Smith, M. (2002) ‘Ethical Difference(s): a Response to Maycroft on Le Corbusier and Lefebvre’, Ethics, Place and Environment, 5(3), 260-269)

Foreword: Control and Conservation of Lampreys Beyond 2020 – Proceedings from the 3rd Sea Lamprey International Symposium (SLIS III)

This special issue summarizes outcomes from the 3rd Sea Lamprey International Symposium (SLIS III; Fig. 1) held 28 July – 2 August 2019 at Wayne State University in Detroit, Michigan, U.S.A. The first two symposia (SLIS I and SLIS II) were held 30 July – 8 August 1979 at Northern Michigan University in Marquette, Michigan and 14–18 August 2000 at Lake Superior State University in Sault Ste. Marie, Michigan, respectively. The published volumes from these symposia in 1980 (Canadian Journal of Fisheries and Aquatic Sciences, Volume 37, Issue 11) and 2003 (Journal of Great Lakes Research Volume 29, Supplement 1) have been invaluable references for the broader scientific community and for management agencies around the Laurentian Great Lakes; cited over 4800 and 3300 times, respectively. SLIS III was attended by over 150 scientists, biologists, resource managers, graduate students, and Commission advisors, including participants from Australia, Canada, China, Japan, New Zealand, Portugal, Spain, the United Kingdom, and the United States (Fig. 2). Similar to SLIS I and SLIS II, the goals of SLIS III were to provide a forum to (i) update and publish information on sea lamprey control and research on lampreys since SLIS II, (ii) exchange knowledge and ideas to bring practitioners to a common plateau of understanding, and (iii) develop innovative initiatives and stimulate new vigor in efforts to control sea lamprey in the Great Lakes and to conserve lampreys in their native ranges. The emphasis on conservation of lampreys is unique to SLIS III and reflects a heightened international recognition that scientific and management advances supporting sea lamprey control in the Great Lakes can benefit the global effort to conserve native lampreys and vice versa

Technoscience and the modernization of freshwater fisheries assessment and management

Inland fisheries assessment and management are challenging given the inherent com- plexity of working in diverse habitats (e.g., rivers, lakes, wetlands) that are dynamic on organisms that are often cryptic and where fishers are often highly mobile. Yet, technoscience is offering new tools that have the potential to reimagine how inland fisheries are assessed and managed. So-called ‘‘technoscience’’ refers to instances in which science and technology unfurl together, offering novel ways of spurring and achieving meaningful change. This paper considers the role of technoscience and its potential for modernizing the assessment and management of inland fisheries. It first explores technoscience and its potential benefits, followed by presentation of a series of synopses that explore the application (both successes and challenges) of new tech- nologies such as environmental DNA (eDNA), genomics, electronic tags, drones, phone apps, iEcology, and artificial intelligence to assessment and management. The paper also considers the challenges and barriers that exist in adopting new technologies. The paper concludes with a provocative assessment of the potential of technoscience to reform and modernize inland fisheries assessment and management. Although these tools are increasingly being embraced, there is a lack of platforms for aggregating these data streams and providing managers with actionable information in a timely manner. The ideas presented here should serve as a catalyst for beginning to work collectively and collaboratively towards fisheries assessment and management systems that harness the power of technology and serve to modernize inland fisheries management. Such transformation is urgently needed given the dynamic nature of environmental change, the evolving threat matrix facing inland waters, and the complex behavior of fishers. Quite simply, a dynamic world demands dynamic fisheries management; technoscience has made that within reach.publishedVersio

Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome

Lenz-Majewski syndrome (LMS) is a syndrome of intellectual disability and multiple congenital anomalies that features generalized craniotubular hyperostosis. By using whole-exome sequencing and selecting variants consistent with the predicted dominant de novo etiology of LMS, we identified causative heterozygous missense mutations in PTDSS1, which encodes phosphatidylserine synthase 1 (PSS1). PSS1 is one of two enzymes involved in the production of phosphatidylserine. Phosphatidylserine synthesis was increased in intact fibroblasts from affected individuals, and end-product inhibition of PSS1 by phosphatidylserine was markedly reduced. Therefore, these mutations cause a gain-of-function effect associated with regulatory dysfunction of PSS1. We have identified LMS as the first human disease, to our knowledge, caused by disrupted phosphatidylserine metabolism. Our results point to an unexplored link between phosphatidylserine synthesis and bone metabolism