Immune sensing of nucleic acids in inflammatory skin diseases.

Endosomal and cytosolic nucleic acid receptors are important immune sensors required for the detection of infecting or replicating viruses. The intracellular location of these receptors allows viral recognition and, at the same time, avoids unnecessary immune activation to self-nucleic acids that are continuously released by dying host cells. Recent evidence, however, indicates that endogenous factors such as anti-microbial peptides have the ability to break this protective mechanism. Here, we discuss these factors and illustrate how they drive inflammatory responses by promoting immune recognition of self-nucleic acids in skin wounds and inflammatory skin diseases such as psoriasis and lupus

Signal and noise simulation of CUORE bolometric detectors

Bolometric detectors are used in particle physics experiments to search for rare processes, such as neutrinoless double beta decay and dark matter interactions. By operating at cryogenic temperatures, they are able to detect particle energies from a few keV up to several MeV, measuring the temperature rise produced by the energy released. This work focusses on the bolometers of the CUORE experiment, which are made of TeO$_2$ crystals. The response of these detectors is nonlinear with energy and changes with the operating temperature. The noise depends on the working conditions and significantly affects the energy resolution and the detection performances at low energies. We present a software tool to simulate signal and noise of CUORE-like bolometers, including effects generated by operating temperature drifts, nonlinearities and pileups. The simulations agree well with data.Comment: Fixed a typo. Two small changes in the text at page

TeO2_2 bolometers with Cherenkov signal tagging: towards next-generation neutrinoless double beta decay experiments

CUORE, an array of 988 TeO$_2$ bolometers, is about to be one of the most sensitive experiments searching for neutrinoless double-beta decay. Its sensitivity could be further improved by removing the background from $\alpha$ radioactivity. A few years ago it has been pointed out that the signal from $\beta$s can be tagged by detecting the emitted Cherenkov light, which is not produced by $\alpha$s. In this paper we confirm this possibility. For the first time we measured the Cherenkov light emitted by a CUORE crystal, and found it to be 100 eV at the $Q$-value of the decay. To completely reject the $\alpha$ background, we compute that one needs light detectors with baseline noise below 20 eV RMS, a value which is 3-4 times smaller than the average noise of the bolometric light detectors we are using. We point out that an improved light detector technology must be developed to obtain TeO$_2$ bolometric experiments able to probe the inverted hierarchy of neutrino masses.Comment: 5 pages, 4 figures. Added referee correction

New experimental limits on the alpha decays of lead isotopes

For the first time a PbWO4 crystal was grown using ancient Roman lead and it was run as a cryogenic detector. Thanks to the simultaneous and independent read-out of heat and scintillation light, the detector was able to discriminate beta/gamma interactions with respect to alpha particles down to low energies. New more stringent limits on the alpha decays of the lead isotopes are presented. In particular a limit of T_{1/2} > 1.4*10^20 y at a 90% C.L. was evaluated for the alpha decay of 204Pb to 200Hg

Discovery of the 151^{151}Eu α\alpha decay

We report on the first compelling observation of $\alpha$ decay of $^{151}$Eu to the ground state of $^{147}$Pm. The measurement was performed using a 6.15 g Li$_6$Eu(BO$_3$)$_3$ crystal operated as a scintillating bolometer. The Q-value and half-life measured are: Q = 1948.9$\pm 6.9(stat.) \pm 5.1(syst.)$ keV, and T$_{1/2}=\left( 4.62\pm0.95(stat.)\pm0.68(syst.)\right) \times 10^{18}$ y . The half-life prediction of nuclear theory using the Coulomb and proximity potential model are in good agreement with this experimental result

Development of a Li2MoO4 scintillating bolometer for low background physics

We present the performance of a 33 g Li2MoO4 crystal working as a scintillating bolometer. The crystal was tested for more than 400 h in a dilution refrigerator installed in the underground laboratory of Laboratori Nazionali del Gran Sasso (Italy). This compound shows promising features in the frame of neutron detection, dark matter search (solar axions) and neutrinoless double-beta decay physics. Low temperature scintillating properties were investigated by means of different alpha, beta/gamma and neutron sources, and for the first time the Light Yield for different types of interacting particle is estimated. The detector shows great ability of tagging fast neutron interactions and high intrinsic radiopurity levels (< 90 \muBq/kg for 238-U and < 110 \muBq/kg for 232-Th).Comment: revised versio

First bolometric measurement of the two neutrino double beta decay of 100^{100}Mo with a ZnMoO4_4 crystals array

The large statistics collected during the operation of a ZnMoO$_4$ array, for a total exposure of 1.3 kg $\cdot$ day of $^{100}$Mo, allowed the first bolometric observation of the two neutrino double beta decay of $^{100}$Mo. The observed spectrum of each crystal was reconstructed taking into account the different background contributions due to environmental radioactivity and internal contamination. The analysis of coincidences between the crystals allowed the assignment of constraints to the intensity of the different background sources, resulting in a reconstruction of the measured spectrum down to an energy of $\sim$300 keV. The half-life extracted from the data is T$_{1/2}^{2\nu}$= [7.15 $\pm$ 0.37 (stat) $\pm$ 0.66 (syst)] $\cdot$ 10$^{18}$ y.Comment: 6 pages, 2 figure, Accepted for publication in Journal of Physics G: Nuclear and Particle Physic

Discrimination of alpha and beta/gamma interactions in a TeO2_2 bolometer

TeO$_2$ crystals have proven to be superb bolometers for the search of neutrinoless double beta decay in many respects. However, if used alone, they do not exhibit any feature that allows to discriminate an alpha energy deposit from a beta/gamma one. This fact limits their ability to reject the background due to natural radioactivity and eventually affects the sensitivity of the search. In this paper we show the results of a TeO$_2$ crystal where, in coincidence with its bolometric heat signal, also the luminescence light escaping the crystal is recorded. The results show that we are able to measure the light produced by beta/gamma particles, which can be explained as due to Cerenkov emission. No light is detected from alpha particles, allowing the rejection of this background source.Comment: 5 pages, 6 figure

Particle discrimination in TeO2 bolometers

TeO2 crystals are used as bolometric detectors in experiments searching for the neutrinoless double beta decay. The extreme rarity of the studied signal requires an ultra low background level. The natural radioactivity of the materials represents for these experiments the main background source, in particular the component due to α particles. In this work, we present a possibility for particle discrimination in TeO2 bolometers using the ˇCerenkov radiation. The results show that we are able to measure the light produced by β/γ particles, which can be explained as due to ˇCerenkov emission. No light is detected from α particles, allowing the rejection of this background source