Advances on Network Protocols and Algorithms for Vehicular Ad Hoc Networks

Vehicular Ad Hoc Network (VANET) is an emerging area of wireless ad hoc networks that facilitates ubiquitous connectivity between smart vehicles through Vehicle-to-Vehicle (V2V) or Vehicle-to-Roadside (V2R) and Roadside-to- Vehicle (R2V) communications. This emerging field of technology aims to improve safety of passengers and traffic flow, reduces pollution to the environment and enables in-vehicle entertainment applications. The safety-related applications could reduce accidents by providing drivers with traffic information such as collision avoidances, traffic flow alarms and road surface conditions. Moreover, the passengers could exploit an available infrastructure in order to connect to the internet for infomobility and entertainment applications.Lloret, J.; Ghafoor, KZ.; Rawat, DB.; Xia, F. (2013). Advances on Network Protocols and Algorithms for Vehicular Ad Hoc Networks. Mobile Networks and Applications. 18(6):749-754. doi:10.1007/s11036-013-0490-7S749754186Lloret J, Canovas A, Catalá A, Garcia M (2013) Group-based protocol and mobility model for VANETs to offer internet access. J Netw Comput Appl 36(3):1027–1038. doi: 10.1016/j.jnca.2012.02.009Khokhar RH, Zia T, Ghafoor KZ, Lloret J, Shiraz M (2013) Realistic and efficient radio propagation model for V2X communications. KSII Trans Internet Inform Syst 7(8):1933–1953. doi: 10.3837/tiis.2013.08.011Ghafoor KZ (2013) Routing protocols in vehicular ad hoc networks: survey and research challenges, Netw Protocol Algorithm 5(4). doi: 10.5296/npa.v5i4.4134Ghafoor KZ, Bakar KA, Lloret J, Ke C-H, Lee KC (2013) Intelligent beaconless geographical routing for urban vehicular environments. Wirel Netw 19(3):345–362. doi: 10.1007/s11276-012-0470-zGhafoor KZ, Bakar KA, Lee K, AL-Hashimi H (2010) A novel delay- and reliability- aware inter-vehicle routing protocol. Netw Protocol Algorithms 2(2):66–88. doi: 10.5296/npa.v2i2.427Dias JAFF, Rodrigues JJPC, Isento JN, Pereira PRBA, Lloret J (2011) Performance assessment of fragmentation mechanisms for vehicular delay-tolerant networks. EURASIP J Wirel Commun Netw 2011(195):1–14. doi: 10.1186/1687-1499-2011-195Zhang D, Yang Z, Raychoudhury V, Chen Z, Lloret J (2013) An energy-efficient routing protocol using movement trend in vehicular Ad-hoc networks. Comput J 58(8):938–946. doi: 10.1093/comjnl/bxt028Ghafoor KZ, Lloret J, Bakar KA, Sadiq AS, Mussa SAB (2013) Beaconing approaches in vehicular Ad Hoc networks: a survey. Wirel Pers Commun. doi: 10.1007/s11277-013-1222-9Sadiq AS, Bakar KA, Ghafoor KZ, Lloret J (2013) An intelligent vertical handover scheme for audio and video streaming in heterogeneous vehicular networks. Mobile Netw Appl. doi: 10.1007/s11036-013-0465-8Khamayseh YM (2013) Network size estimation in VANETs. Netw Protocol Algorithm 5(3):136–152. doi: 10.5296/npa.v5i6.3838Rawat DB, Popescu DC, Yan G, Olariu S (2011) Enhancing VANET performance by joint adaptation of transmission power and contention window size. IEEE Trans Parallel Distrib Syst 22(9):1528–1535Yan G, Rawat DB, Bista BB. Provisioning vehicular ad hoc networks with quality of services. Int J Space-Based Situated Comput 2(2):104–111Rawat DB, Bista BB, Yan G, Weigle MC (2011) Securing vehicular ad-hoc networks against malicious drivers: a probabilistic approach, International Conference on Complex, Intelligent, and Software Intensive Systems Pp. 146–151. June 30, 2011Sun W, Xia F, Ma J, Fu T, Sun Y. An optimal ODAM-based broadcast algorithm for vehicular Ad-Hoc Networks. KSII Trans Internet Inform Syst 6(12): 3257–3274Vinel AV, Dudin AN, Andreev SD, Xia F (2010) Performance modeling methodology of emergency dissemination algorithms for vehicular ad-hoc networks, 6th Communication Systems, Networks & Digital Signal Processing (CSNDSP 2010), Pp. 397–400AL-Hashimi HN, Bakar KA, Ghafoor KZ (2010) Inter-domain proxy mobile IPv6 based vehicular network. Netw Protocol Algorithm 2(4):1–15. doi: 10.5296/npa.v2i4.488Ghafoor KZ, Bakar KA, Mohammed MA, Lloret J (2013) Vehicular cloud computing: trends and challenges, in the book “mobile computing over cloud: technologies, services, and applications”. IGI GlobalYan G, Rawat DB, Bista BB (2012) Towards secure vehicular clouds, Sixth International Conference on Complex, Intelligent and Software Intensive Systems (CISIS 2012), Pp. 370–375Fernández H, Rubio L, Reig J, Rodrigo-Peñarrocha VM, Valero A (2013) Path loss modeling for vehicular system performance and communication protocols evaluation. Mobile Netw Appl. doi: 10.1007/s11036-013-0463-xAllouche Y, Segal M (2013) A cluster-based beaconing approach in VANETs: near optimal topology via proximity information. Mobile Netw Appl. doi: 10.1007/s11036-013-0468-5Merah AF, Samarah S, Boukerche A, Mammeri A (2013) A sequential patterns data mining approach towards vehicular route prediction in VANETs. Mobile Netw Appl. doi: 10.1007/s11036-013-0459-6Zhang D, Huang H, Zhou J, Xia F, Chen Z (2013) Detecting hot road mobility of vehicular Ad Hoc Networks. Mobile Netw Appl. doi: 10.1007/s11036-013-0467-6El Ajaltouni H, Boukerche A, Mammeri A (2013) A multichannel QoS MAC with dynamic transmit opportunity for. Mobile Netw Appl. doi: 10.1007/s11036-013-0475-6Reñé S, Esparza O, Alins J, Mata-Díaz J, Muñoz JL (2013) VSPLIT: a cross-layer architecture for V2I TCP services over. Mobile Netw Appl. doi: 10.1007/s11036-013-0473-8Blanco B, Liberal F (2013) Amaia Aguirregoitia, application of cognitive techniques to adaptive routing for VANETs in city environments. Mobile Netw Appl. doi: 10.1007/s11036-013-0466-7Kim J, Krunz M (2013) Spectrum-aware beaconless geographical routing protocol for cognitive radio enabled vehicular networks. Mobile Netw Appl. doi: 10.1007/s11036-013-0476-5Dias JAFF, Rodrigues JJPC, Isento JNG, Niu J (2013) The impact of cooperative nodes on the performance of vehicular delay-tolerant networks. Mobile Netw Appl. doi: 10.1007/s11036-013-0464-9Sadiq AS, Bakar KA, Ghafoor KZ, Lloret J, Khokhar R (2013) An intelligent vertical handover scheme for audio and video streaming in heterogeneous vehicular networks. Mobile Netw Appl. doi: 10.1007/s11036-013-0465-8Machado S, Ozón J, González AJ, Ghafoor KZ (2013) Structured peer-to-peer real time video transmission over vehicular Ad Hoc networks. Mobile Netw Appl. doi: 10.1007/s11036-013-0461-zLin C, Wu G, Xia F, Yao L (2013) Enhance the attacking efficiency of the node compromise attack in vehicular Ad-hoc network using connected dominating set. Mobile Netw Appl. doi: 10.1007/s11036-013-0469-

Enhanced dissolution efficiency of tamoxifen combined with methacrylate copolymers in amorphous solid dispersions

Amorphous solid dispersions (SDs) containing poorly soluble tamoxifen dispersed in a meth(acrylate) copolymer combination were proposed as a controlled release system. The objective of this work was to investigate the characteristics and performance of the tamoxifen–polymer mixture and evaluate the changes in functionality through a supersaturating dissolution study condition while comparing it to a physical mixture at a fixed drug-loading proportion. Two polymers, Eudragit® L 100 and Eudragit® RL 100, were used to prepare SDs with a 1:1 polymer ratio, containing 10%, 20%, or 30% (wt/wt%) of tamoxifen, by the solvent evaporation method. A physical mixture containing 30% of tamoxifen was also prepared for comparison. SDs were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. Dissolution tests were conducted under non-sink conditions to verify the occurrence of drug recrystallization upon its release. Solid-state characterizations confirmed that the drug was in the amorphous state within the polymeric matrix. Tamoxifen release in an acidic medium was mainly affected by the increase in drug concentration caused by the possible loss of interactions that characterize the main polymer functionalities. At pH 7.4, supersaturation was slowly achieved while also contributing to the increase in the kinetic solubility of the drug. The physical mixture demonstrated the best overall performance, suggesting that the polymeric interactions may have negatively affected the drug release. The combination of polymers in the composing SD proved to be a promising strategy to tailor the delivery of poorly soluble drugs. Our study highlights important information on the behavior of tamoxifen as a poorly soluble drug in supersaturating dissolution conditions while released from SD systems.This work was funded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Brazil), by the Portuguese Science and Technology Foundation (FCT/MCT), and European Funds (PRODER/COMPETE) under the projects M-ERA-NET/0004/2015 and UIDB/04469/2020 (strategic fund) and co-financed by FEDER under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersio

Phosphoproteomics of retinoblastoma:A pilot study identifies aberrant kinases

Retinoblastoma is a malignant tumour of the retina which most often occurs in children. Earlier studies on retinoblastoma have concentrated on the identification of key players in the disease and have not provided information on activated/inhibited signalling pathways. The dysregulation of protein phosphorylation in cancer provides clues about the affected signalling cascades in cancer. Phosphoproteomics is an ideal tool for the study of phosphorylation changes in proteins. Hence, global phosphoproteomics of retinoblastoma (RB) was carried out to identify signalling events associated with this cancer. Over 350 proteins showed differential phosphorylation in RB compared to control retina. Our study identified stress response proteins to be hyperphosphorylated in RB which included H2A histone family member X (H2AFX) and sirtuin 1. In particular, Ser140 of H2AFX also known as gamma-H2AX was found to be hyperphosphorylated in retinoblastoma, which indicated the activation of DNA damage response pathways. We also observed the activation of anti-apoptosis in retinoblastoma compared to control. These observations showed the activation of survival pathways in retinoblastoma. The identification of hyperphosphorylated protein kinases including Bromodomain containing 4 (BRD4), Lysine deficient protein kinase 1 (WNK1), and Cyclin-dependent kinase 1 (CDK1) in RB opens new avenues for the treatment of RB. These kinases can be considered as probable therapeutic targets for RB, as small-molecule inhibitors for some of these kinases are already in clinical trials for the treatment other cancers

Studying the Impact of Initialization for Population-Based Algorithms with Low-Discrepancy Sequences

To solve different kinds of optimization challenges, meta-heuristic algorithms have been extensively used. Population initialization plays a prominent role in meta-heuristic algorithms for the problem of optimization. These algorithms can affect convergence to identify a robust optimum solution. To investigate the effectiveness of diversity, many scholars have a focus on the reliability and quality of meta-heuristic algorithms for enhancement. To initialize the population in the search space, this dissertation proposes three new low discrepancy sequences for population initialization instead of uniform distribution called the WELL sequence, Knuth sequence, and Torus sequence. This paper also introduces a detailed survey of the different initialization methods of PSO and DE based on quasi-random sequence families such as the Sobol sequence, Halton sequence, and uniform random distribution. For well-known benchmark test problems and learning of artificial neural network, the proposed methods for PSO (TO-PSO, KN-PSO, and WE-PSO), BA (BA-TO, BA-WE, and BA-KN), and DE (DE-TO, DE-WE, and DE-KN) have been evaluated. The synthesis of our strategies demonstrates promising success over uniform random numbers using low discrepancy sequences. The experimental findings indicate that the initialization based on low discrepancy sequences is exceptionally stronger than the uniform random number. Furthermore, our work outlines the profound effects on convergence and heterogeneity of the proposed methodology. It is expected that a comparative simulation survey of the low discrepancy sequence would be beneficial for the investigator to analyze the meta-heuristic algorithms in detail

Understanding the Effects of Both CD14-Mediated Innate Immunity and Device/Tissue Mechanical Mismatch in the Neuroinflammatory Response to Intracortical Microelectrodes

Intracortical microelectrodes record neuronal activity of individual neurons within the brain, which can be used to bridge communication between the biological system and computer hardware for both research and rehabilitation purposes. However, long-term consistent neural recordings are difficult to achieve, in large part due to the neuroinflammatory tissue response to the microelectrodes. Prior studies have identified many factors that may contribute to the neuroinflammatory response to intracortical microelectrodes. Unfortunately, each proposed mechanism for the prolonged neuroinflammatory response has been investigated independently, while it is clear that mechanisms can overlap and be difficult to isolate. Therefore, we aimed to determine whether the dual targeting of the innate immune response by inhibiting innate immunity pathways associated with cluster of differentiation 14 (CD14), and the mechanical mismatch could improve the neuroinflammatory response to intracortical microelectrodes. A thiol-ene probe that softens on contact with the physiological environment was used to reduce mechanical mismatch. The thiol-ene probe was both softer and larger in size than the uncoated silicon control probe. Cd14-/- mice were used to completely inhibit contribution of CD14 to the neuroinflammatory response. Contrary to the initial hypothesis, dual targeting worsened the neuroinflammatory response to intracortical probes. Therefore, probe material and CD14 deficiency were independently assessed for their effect on inflammation and neuronal density by implanting each microelectrode type in both wild-type control and Cd14-/- mice. Histology results show that 2 weeks after implantation, targeting CD14 results in higher neuronal density and decreased glial scar around the probe, whereas the thiol-ene probe results in more microglia/macrophage activation and greater blood–brain barrier (BBB) disruption around the probe. Chronic histology demonstrate no differences in the inflammatory response at 16 weeks. Over acute time points, results also suggest immunomodulatory approaches such as targeting CD14 can be utilized to decrease inflammation to intracortical microelectrodes. The results obtained in the current study highlight the importance of not only probe material, but probe size, in regard to neuroinflammation

Numerical study of the environmental and economic system through the computational heuristic based on artificial neural networks

In this study, the numerical computation heuristic of the environmental and economic system using the artificial neural networks (ANNs) structure together with the capabilities of the heuristic global search genetic algorithm (GA) and the quick local search interior-point algorithm (IPA), i.e., ANN-GA-IPA. The environmental and economic system is dependent of three categories, execution cost of control standards and new technical diagnostics elimination costs of emergencies values and the competence of the system of industrial elements. These three elements form a nonlinear differential environmental and economic system. The optimization of an error-based objective function is performed using the differential environmental and economic system and its initial conditions. The optimization of an error-based objective function is performed using the differential environmental and economic system and its initial conditions

Evolutionary Integrated Heuristic with Gudermannian Neural Networks for Second Kind of Lane–Emden Nonlinear Singular Models

In this work, a new heuristic computing design is presented with an artificial intelligence approach to exploit the models with feed-forward (FF) Gudermannian neural networks (GNN) accomplished with global search capability of genetic algorithms (GA) combined with local convergence aptitude of active-set method (ASM), i.e., FF-GNN-GAASM to solve the second kind of Lane–Emden nonlinear singular models (LE-NSM). The proposed method based on the computing intelligent Gudermannian kernel is incorporated with the hidden layer configuration of FF-GNN models of differential operatives of the LE-NSM, which are arbitrarily associated with presenting an error-based objective function that is used to optimize by the hybrid heuristics of GAASM. Three LE-NSM-based examples are numerically solved to authenticate the effectiveness, accurateness, and efficiency of the suggested FF-GNN-GAASM. The reliability of the scheme via statistical valuations is verified in order to authenticate the stability, accuracy, and convergence