A simple method for the determination of the structure of ultrashort relativistic electron bunches

In this paper we propose a new method for measurements of the longitudinal profile of 100 femtosecond electron bunches for X-ray Free Electron Lasers (XFELs). The method is simply the combination of two well-known techniques, which where not previously combined to our knowledge. We use seed 10-ps 1047 nm quantum laser to produce exact optical replica of ultrafast electron bunches. The replica is generated in apparatus which consists of an input undulator (energy modulator), and the short output undulator (radiator) separated by a dispersion section. The radiation in the output undulator is excited by the electron bunch modulated at the optical wavelength and rapidly reaches 100 MW-level peak power. We then use the now-standard method of ultrashort laser pulse-shape measurement, a tandem combination of autocorrelator and spectrum (FROG -- frequency resolved optical gating). The FROG trace of the optical replica of electron bunch gives accurate and rapid electron bunch shape measurements in a way similar to a femtosecond oscilloscope. Real-time single-shot measurements of the electron bunch structure could provide significant information about physical mechanisms responsible for generation ultrashort electron bunches in bunch compressors. The big advantage of proposed technique is that it can be used to determine the slice energy spread and emittance in multishot measurements. It is possible to measure bunch structure completely, that is to measure peak current, energy spread and transverse emittance as a function of time. We illustrate with numerical examples the potential of the proposed method for electron beam diagnostics at the European X-ray FEL.Comment: 41 pages, 18 figure

Emittance growth of a short electron bunch in circular motion

A short electron bunch undergoing circular motion produces space-charge forces that do not decrease with increasing bunch energy, unlike those induced by straight-line motion. These energy-independent forces can be separated into a noninertial space-charge force and a coherent synchrotron radiation force. These forces result in an energy spread in the bunch, and can lead to a potentially large emittance growth. These effects can take place in both (1) bunch compression systems used to increase the peak current and (2) the wiggler itself Numerical estimates of the emittance growth in a wiggler for a 1-ps long, 1-mm radius, 1-nC electron bunch can be as large as 0.1 {pi} mm mrad per wiggle period; the energy spread can grow as much as 30 keV per wiggle period. These types of beam quality degradation may become significant for future, short-wavelength free-electron lasers requiring high-brightness electron beams, especially for self-amplified spontaneous emission operation

Laser Stabilization at 1536 nm Using Regenerative Spectral Hole Burning

Laser frequency stabilization giving a 500-Hz Allan deviation for a 2-ms integration time with drift reduced to 7 kHz/min over several minutes was achieved at 1536 nm in the optical communication band. A continuously regenerated spectral hole in the inhomogeneously broadened 4I15/2(1)!4I13/2(1) optical absorption of an Er31:Y2SiO5 crystal was used as the short-term frequency reference, while a variation on the locking technique allowed simultaneous use of the inhomogeneously broadened absorption line as a long-term reference. The reported frequency stability was achieved without vibration isolation. Spectral hole burning frequency stabilization provides ideal laser sources for high-resolution spectroscopy, real-time optical signal processing, and a range of applications requiring ultra-narrow-band light sources or coherent detection; the time scale for stability and the compatibility with spectral hole burning devices make this technique complementary to other frequency references for laser stabilization

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation

Background Allergic disease affects 30% to 40% of the world's population, and its development is determined by the interplay between environmental and inherited factors. Air pollution, primarily consisting of diesel exhaust emissions, has increased at a similar rate to allergic disease. Exposure to diesel exhaust may play a role in the development and progression of allergic disease, in particular allergic respiratory disease. One potential mechanism underlying the connection between air pollution and increased allergic disease incidence is DNA methylation, an epigenetic process with the capacity to integrate gene-environment interactions. Objective We sought to investigate the effect of allergen and diesel exhaust exposure on bronchial epithelial DNA methylation. Methods We performed a randomized crossover-controlled exposure study to allergen and diesel exhaust in humans, and measured single-site (CpG) resolution global DNA methylation in bronchial epithelial cells. Results Exposure to allergen alone, diesel exhaust alone, or allergen and diesel exhaust together (coexposure) led to significant changes in 7 CpG sites at 48 hours. However, when the same lung was exposed to allergen and diesel exhaust but separated by approximately 4 weeks, significant changes in more than 500 sites were observed. Furthermore, sites of differential methylation differed depending on which exposure was experienced first. Functional analysis of differentially methylated CpG sites found genes involved in transcription factor activity, protein metabolism, cell adhesion, and vascular development, among others. Conclusions These findings suggest that specific exposures can prime the lung for changes in DNA methylation induced by a subsequent insult

Transverse emittance measurements on an S-band photoinjector rf electron gun

Proposed fourth generation light sources using SASE FELs to generate short pulse, coherent, X-rays require demonstration of high brightness electron sources. The Gun Test Facility (GTF) at SLAC was built to test high brightness sources for the proposed Linac Coherent Light Source at SLAC. The transverse emittance measurements are made at nearly 30 MeV by measuring the spot size on a YAG screen using the quadrupole scan technique. The emittance was measured to vary from 1 to 3.5 mm-mrad as the charge is increased from 50 to 350 pC using a laser pulse width of 2 ps FWHM. The measurements are in good agreement with simulation results using the LANL version of PARMELA.Comment: 12 pages, 4 figures, contributed to The 23rd Int. FEL Conf., Darmstadt, 20-24 Aug. 200

CoSyR: a novel beam dynamics code for the modeling of synchrotron radiation effects

The self-consistent nonlinear dynamics of a relativistic charged particle beam interacting with its complete self-fields is a fundamental problem underpinning many of the accelerator design issues in high brightness beam applications, as well as the development of advanced accelerators. Particularly, synchrotron radiation induced effects in a magnetic dispersive beamline element can lead to collective beam instabilities and emittance growth. A novel beam dynamic code is developed based on a Lagrangian method for the calculation of the particles' radiation near-fields using wavefront/wavelet meshes via the Green's function of the Maxwell equations. These fields are then interpolated onto a moving mesh for dynamic update of the beam. This method allows radiation co-propagation and self-consistent interaction with the beam in the simulation at greatly reduced numerical errors. Multiple levels of parallelisms are inherent in this method and implemented in our code CoSyR to enable at-scale simulations of nonlinear beam dynamics on modern computing platforms using MPI, multi-threading, and GPUs. CoSyR has been used to evaluate the transverse and longitudinal coherent radiation effects on the beam and to investigate beam optics designs proposed for mitigation of beam brightness degradation in a magnetic bunch compressor. In this paper, the design of CoSyR, as well as the benchmark with other coherent synchrotron radiation models, are described and discussed.Comment: 17 pages, 14 figure

NGC 5846-UDG1: A Galaxy Formed Mostly by Star Formation in Massive, Extremely Dense Clumps of Gas

It has been shown that ultra-diffuse galaxies (UDGs) have higher specific frequencies of globular clusters, on average, than other dwarf galaxies with similar luminosities. The UDG NGC 5846-UDG1 is among the most extreme examples of globular cluster-rich galaxies found so far. Here we present new Hubble Space Telescope observations and analysis of this galaxy and its globular cluster system. We find that NGC 5846-UDG1 hosts 54 ± 9 globular clusters, three to four times more than any previously known galaxy with a similar luminosity and higher than reported in previous studies. With a galaxy luminosity of L V,gal ≈ 6 × 107 L ⊙ (M ⋆ ≈ 1.2 × 108 M ⊙) and a total globular cluster luminosity of L V,GCs ≈ 7.6 × 106 L ⊙, we find that the clusters currently comprise ∼13% of the total light. Taking into account the effects of mass loss from clusters during their formation and throughout their lifetime, we infer that most of the stars in the galaxy likely formed in globular clusters, and very little to no normal low-density star formation occurred. This result implies that the most extreme conditions during early galaxy formation promoted star formation in massive and dense clumps, in contrast to the dispersed star formation observed in galaxies today

Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male Mice

Androgens have profound effects on T cell homeostasis, including regulation of thymic T lymphopoiesis (thymopoiesis) and production of recent thymic emigrants (RTEs), i. e., immature T cells that derive from the thymus and continue their maturation to mature naive T cells in secondary lymphoid organs. Here we investigated the androgen target cell for effects on thymopoiesis and RTEs in spleen and lymph nodes. Male mice with a general androgen receptor knockout (G-ARKO), T cell-specific (T-ARKO), or epithelial cell-specific (E-ARKO) knockout were examined. G-ARKO mice showed increased thymus weight and increased numbers of thymic T cell progenitors. These effects were not T cell-intrinsic, since T-ARKO mice displayed unaltered thymus weight and thymopoiesis. In line with a role for thymic epithelial cells (TECs), E-ARKO mice showed increased thymus weight and numbers of thymic T cell progenitors. Further, E-ARKO mice had more CD4(+)and CD8(+)T cells in spleen and an increased frequency of RTEs among T cells in spleen and lymph nodes. Depletion of the androgen receptor in epithelial cells was also associated with a small shift in the relative number of cortical (reduced) and medullary (increased) TECs and increased CCL25 staining in the thymic medulla, similar to previous observations in castrated mice. In conclusion, we demonstrate that the thymic epithelium is a target compartment for androgen-mediated regulation of thymopoiesis and consequently the generation of RTEs