High-power cladding pumped Tm-doped silica fiber laser with wavelength tuning from 1860 to 2090 nm

A high-power double-clad Tm-doped silica fiber laser, pumped by two beam-shaped and polarization-coupled diode bars at 787nm, was wavelength tuned by use of an external cavity containing a diffraction grating. The Tm fiber laser produced a maximum output power of 7W at 1940nm for 40W of incident diode power and was tuned over a wavelength range of 230nm from 1860 to 2090nm, with 5 W output power over the range 1870 2040nm. The prospects for further improvement in performance and extension of the tuning range are discussed

Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

Contilisant, a permeable, antioxidant, and neuroprotectant agent, showing high nM affinity at H3R and excellent inhibition of the monoamine oxidases and cholinesterases, is an affine and selective S1R agonist in the nanomolar range, based on the binding affinity and functional experiment, a result confirmed by molecular modeling. In addition, contilisant significantly restores the cognitive deficit induced by Aβ in the radial maze assay in an in vivo Alzheimer's disease test, comparing very favorably with donepezil.J.M.-C. thanks MINECO (Grant SAF2015-65586-R), UCJC (Grants 2015-12, 2014-35, and 2015-21), and EU (COST Action CA15135) for support. J.M.-C. thanks Prof. Stark and Prof. Ramsay, as well as Prof. Jia (Beijing Normal University), Dr. Chioua (CSIC), and Dr. Romero (UCM) for their help and support.Peer Reviewe