Cutting load capacity of end mills with complex geometry

Cutting load capacity of cemented carbide end mills with high length-to-diameter ratios is determined from critical geometric and loading parameters, including a stress concentration factor (SCF) to account for serrated edges, which is determined by finite element analysis. Tensile strengths are characterised using a statistical Weibull analysis from 4-point bend tests of cemented carbide blanks of two different diameters. The approach is used to predict probability of survival for cutters under different loading conditions. Results are compared to measured failure cutting loads under service conditions as well as to those measured in static three point bend tests

An experimental investigation of chatter effects on tool life

Tool wear is one of the most important considerations in machining operations as it affects surface quality and integrity, productivity and cost. The most commonly used model for tool life analysis is the one proposed by F.W. Taylor about a century ago. Although the extended form of this equation includes the effects of important cutting conditions on tool wear, tool life studies are mostly performed under stable cutting conditions where the effect of chatter vibrations are not considered. This paper presents an empirical attempt to understand tool life under vibratory cutting conditions. Tool wear data are collected in turning and milling on different work materials under stable and chatter conditions. The effects of cutting conditions as well as severity of chatter on tool life are analyzed. The results indicate significant reduction in tool life due to chatter as expected. They also show that the severity of chatter, and thus the vibration amplitude, strongly reduces the life of cutting tools. These results can be useful in evaluating the real cost of chatter by including the reduced tool life. They can also be useful in justifying the cost of chatter suppression and more rigid machining systems

Evolution of Conversations in the Age of Email Overload

Email is a ubiquitous communications tool in the workplace and plays an important role in social interactions. Previous studies of email were largely based on surveys and limited to relatively small populations of email users within organizations. In this paper, we report results of a large-scale study of more than 2 million users exchanging 16 billion emails over several months. We quantitatively characterize the replying behavior in conversations within pairs of users. In particular, we study the time it takes the user to reply to a received message and the length of the reply sent. We consider a variety of factors that affect the reply time and length, such as the stage of the conversation, user demographics, and use of portable devices. In addition, we study how increasing load affects emailing behavior. We find that as users receive more email messages in a day, they reply to a smaller fraction of them, using shorter replies. However, their responsiveness remains intact, and they may even reply to emails faster. Finally, we predict the time to reply, length of reply, and whether the reply ends a conversation. We demonstrate considerable improvement over the baseline in all three prediction tasks, showing the significant role that the factors that we uncover play, in determining replying behavior. We rank these factors based on their predictive power. Our findings have important implications for understanding human behavior and designing better email management applications for tasks like ranking unread emails.Comment: 11 page, 24th International World Wide Web Conferenc

The analysis of particles emission during the process of grinding of steel EN 90MNV8

Metal grinding is a one of the manufacturing technologies that is greatly connected to particles emission. Particles generated during the grinding process are dangerous in terms of its potential penetration deeply into the lungs of an operator. The level of risk for human respiratory system is related to nature, shape and size of the particles, and for this reason it is important to have a quality characterization of emitted particles. This paper focuses on particles characterization on the bases of image analysis from scanning electron microscopy (SEM). The research was conducted during the process of grinding of steel EN 90MnV8, using personal sampler. Results of image analysis, consisted of Feret’s diameter and circularity, showed quite a wide range of sizes and significant deviation of particles from regular shape

MR-Eye:High-Resolution Microscopy Coil MRI for the Assessment of the Orbit and Periorbital Structures, Part 2: Clinical Applications

In the first part of this 2-part series, we described how to implement microscopy coil MR imaging of the orbits. Beyond being a useful anatomic educational tool, microscopy coil MR imaging has valuable applications in clinical practice. By depicting deep tissue tumor extension, which cannot be evaluated clinically, ophthalmic surgeons can minimize the surgical field, preserve normal anatomy when possible, and maximize the accuracy of resection margins. Here we demonstrate common and uncommon pathologies that may be encountered in orbital microscopy coil MR imaging practice and discuss the imaging appearance, the underlying pathologic processes, and the clinical relevance of the microscopy coil MR imaging findings.</p

Plant Small Non-coding RNAs and Their Roles in Biotic Stresses

Non-coding RNAs (ncRNAs) have emerged as critical components of gene regulatory networks across a plethora of plant species. In particular, the 20–30 nucleotide small ncRNAs (sRNAs) play important roles in mediating both developmental processes and responses to biotic stresses. Based on variation in their biogenesis pathways, a number of different sRNA classes have been identified, and their specific functions have begun to be characterized. Here, we review the current knowledge of the biogenesis of the primary sRNA classes, microRNA (miRNA) and small nuclear RNA (snRNA), and their respective secondary classes, and discuss the roles of sRNAs in plant–pathogen interactions. sRNA mobility between species is also discussed along with potential applications of sRNA–plant–pathogen interactions in crop improvement technologies

Tool path pattern and feed direction selection in robotic milling for increased chatter-free material removal rate

Robotic milling becomes increasingly relevant to large-scale part manufacturing industries thanks to its cost-effective and portable manufacturing concept compared to large-scale CNC machine tools. Integration of milling processes with industrial robots is proposed to be well aligned with the aims and objective of the recent fourth industrial revolution. However, the industrial robots introduce position-dependent and asymmetrical dynamic flexibility, which may reflect to the tool tip dynamics under several conditions. Under such circumstances, the stability limits become dependent on the machining location and the feed direction. In this respect, selection of machining tool path patterns is crucial for increased chatter-free material removal rates (MRR). This paper proposes an approach to evaluate and select tool path patterns, offered by the existing CAM packages, for increased chatter-free MRR. The machining area is divided into number of machining locations. The optimal feed direction is decided based on the absolute stability at each region considering the asymmetrical and position-dependent tool tip dynamics. Then, the alternative tool path patterns are evaluated and the corresponding optimum feed direction is decided for increased chatter-free material removal. The application of the proposed approach is demonstrated through simulations and representative experiments

Re-CAD/CAM pristup projektovanju i izradi zubnih keramičkih navlaka u kombinaciji sa ručnim individualnim prilagođavanjem

CAD/CAM technology in dentistry offers high-end ceramic restorations, known for its quality, preciseness, swiftness and repeatability. However, some features are still human-dependent. A young female patient required smile enhancement, since suffering from colour change on three devitalized frontal teeth. After fiber post placement, teeth were prepared for metal-free restoration. Consequently, abutments were scanned using extraoral scanner (Sirona, InEos Blue; Beinsheim, Germany). CAD software (version 3.8) has been used to create three crown copings, with cut-back in the incisal region. After finalization of the virtual modeling, data file has been transferred to a milling unit (Sirona, MCXL, Beinsheim, Germany) that produced crown copings out of a ceramic block (IPS e.max CAD, Ivoclar Vivadent, Schaan, Liechtestein). Crowns were tried for the fit and occlusion in the so-called blue stage, after which final strength and shape has been achieved by thermal treatment in the ceramic furnace. Individualization has been done manually, creating special effect in the cut-back region. Crowns were cemented adhesively. CAD/CAM offers modern and relevant way of producing ceramic restorations, however, special effects still require manual adjustments.CAD/CAM tehnologije u stomatologiji nude visoko kvalitetne keramičke zamene, poznate po kvalitetu, preciznosti, brzini izrade i ponovljivosti. Međutim neke opcije još uvek zavise od ljudske intervencije. Mlada pacijentkinja je imala zahtev za poboljšanjem osmeha, pošto je patila od promene boje na tri prednja nezdrava zuba. Posle instalacije vlaknene podloge, zubi su bili spremni za bez-metalnu reparaciju. Otisci su bili skenirani ekstraoralnim skenerom (Sirona, InEos Blue, Beinsheim, Nemačka). CAD softver (verzija 3.8) je korišćen za generisanje tri navlake. Po završetku virtuelnog modeliranja podaci su prebačeni na glodalicu (Sirona, MCXL, Beinsheim, Nemačka) koja je izradila navlake od keramičkih blokova (IPS-a, max CAD, Ivoclar Vivadent, Schaan, Lihtenštajn). Navlake su posle isprobane zbog procene naleganja i začepljenja u tzv. plavoj etapi, posle čega je konačno očvršćavanje i oblikovanje postignuto termičkom obradom u peći za keramiku. Individualno prilagođavanje je izvršeno ručno, sa izradom posebnog efekta u zadnjem delu. Navlake su cementirane adhezijom. CAD/CAM nudi moderan i važan način u izradi keramičkih implanta ali posebni efekti još uvek zahtevaju intervenciju čoveka

Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cells.

When cell populations are incubated with the DNA-binding dye Hoechst 33342 and subjected to flow cytometry analysis for Hoechst 33342 emissions, active efflux of the dye by the ABCG2/BCRP1 transporter causes certain cells to appear as a segregated cohort, known as a side population (SP). Stem cells from several tissues have been shown to possess the SP phenotype. As the lack of specific surface markers has hindered the isolation and subsequent biochemical characterization of epithelial stem cells this study sought to determine the existence of SP cells and expression of ABCG2 in the epithelia of the ocular surface and evaluate whether such SP cells had features associated with epithelial stem cells. Human and rabbit limbal-corneal and conjunctival epithelial cells were incubated with Hoechst 33342, and analyzed and sorted by flow cytometry. Sorted cells were subjected to several tests to determine whether the isolated SP cells displayed features consistent with the stem cell phenotype. Side populations amounting to \u3c1% of total cells, which were sensitive to the ABCG2-inhibitor fumitremorgin C, were found in the conjunctival and limbal epithelia, but were absent from the stem cell-free corneal epithelium. Immunohistochemistry was used to establish the spatial expression pattern of ABCG2. The antigen was detected in clusters of conjunctival and limbal epithelia basal cells but was not present in the corneal epithelium. SP cells were characterized by extremely low light side scattering and contained a high percentage of cells that: showed slow cycling prior to tissue collection; exhibited an initial delay in proliferation after culturing; and displayed clonogenic capacity and resistance to phorbol-induced differentiation; all features that are consistent with a stem cell phenotype