1,388 research outputs found

    PDG9: THE EVENT AND STATE COST OF COMPLICATIONS OF DIABETES IN THE NETHERLANDS

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    Max-plus algebra in the history of discrete event systems

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    This paper is a survey of the history of max-plus algebra and its role in the field of discrete event systems during the last three decades. It is based on the perspective of the authors but it covers a large variety of topics, where max-plus algebra plays a key role

    Foliicolous lichens from Suriname and Guyana: new records and three new species

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    Sampling of foliicolous lichens by the first author in Suriname in 2014 resulted in 103 records of lichenized and lichenicolous fungi for Suriname, including 89 first records for the country and one undescribed species. Fieldwork in Guyana by the second author in 1992 and 1997 brought 29 new records, including a new chemical strain for Loflammea epiphylla and two undescribed species. A full list for Suriname is presented (130 taxa), the additions for Guyana are listed, and the new species Calenia surinamensis, Enterographa paruimae and Strigula transversoundulata are described.

    Genetic and epigenetic alterations that drive leukemic stem cell self-renewal

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    Acute myeloid leukemia has emerged as a paradigm for the concept of the cancer stem cell. This hypothesis presumes that the disease is maintained by a rare population of leukemia-initiating stem cells which have acquired genetic or epigenetic changes. It is most likely that a single (epi)genetic event will not be sufficient to cause leukemia, but that a number of sequential events are required. Similar to normal hematopoietic stem cells, both intrinsic as well as extrinsic factors that arise from the bone marrow niche, provide essential cues that regulate cell fate decisions such as leukemic stem cell self-renewal and differentiation. In this chapter, we will review the genetic and epigenetic abnormalities that underlie the process of leukemic transformation, and will discuss which events potentially co-operate to induce leukemia

    Genetic and epigenetic alterations that drive leukemic stem cell self-renewal

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