Study on the prevalence of bovine fasciolosis in and around Bahir Dar, Ethiopia

A cross sectional study aimed at determining the prevalence and type of common Fasciola species in cattle was conducted in and around Bahir Dar from November 2008- March 2009. The study was based on post-mortem inspection of livers of slaughtered animals at Bahir Dar municipality abattoir and coprological examination using sedimentation technique on fecal samples collected from animals of Bahir Dar and surrounding areas. Out of 413 livers inspected, 165 (39.95%) were positive for Fasciola species. F. hepatica was found to be the most prevalent species in cattle of the study area (89.70%). About 3.63% were positive for F. gigantica and 6.67% were harboring mixed infections. Likewise, out of 384 fecal samples examined 141 (36.72) were positive for the presence of Fasciola eggs. Risk factors such as locality, body condition and sex didn’t show any effect on the prevalence of infections (P>0.05). However, breed and age group revealed significant disparity (P<0.05) as greater magnitude of infections were detected in exotic breed and young age group, respectively. In view of the current result, fasciolosis could be considered as a major problem in Bahir Dar and surrounding areas as the ecological factors and management conditions are suitable both for the snail intermediate host and the parasite to be maintained. Strategic treatments need to be implemented at appropriate timing with the aim of reducing worm burden from infected animals and preclude pasture contamination. Integrated control approaches involving livestock owners has to be implemented in reducing the population and activity of snail intermediate hosts to enable maximization of long-term returns from such endemic areas.Key words: Abattoir, Bovine, Bahir Dar, Coprology, Fasciola, Prevalence

The initial Mayo Clinic experience using high-frequency oscillatory ventilation for adult patients: a retrospective study

BACKGROUND: High-frequency oscillatory ventilation (HFOV) was introduced in our institution in June 2003. Since then, there has been no protocol to guide the use of HFOV, and all decisions regarding ventilation strategies and settings of HFOV were made by the treating intensivist. The aim of this study is to report our first year of experience using HFOV. METHODS: In this retrospective study, we reviewed all 14 adult patients, who were consecutively ventilated with HFOV in the intensive care units of a tertiary medical center, from June 2003 to July 2004. RESULTS: The mean age of the patients was 56 years, 10 were males, and all were whites. The first day median APACHE II score and its predicted hospital mortality were 35 and 83%, respectively, and the median SOFA score was 11.5. Eleven patients had ARDS, two unilateral pneumonia with septic shock, and one pulmonary edema. Patients received conventional ventilation for a median of 1.8 days before HFOV. HFOV was used 16 times for a median of 3.2 days. Improvements in oxygenation parameters were observed after 24 hours of HFOV (mean PaO(2)/FIO(2 )increased from 82 to 107, P < 0.05; and the mean oxygenation index decreased from 42 to 29; P < 0.05). In two patients HFOV was discontinued, in one because of equipment failure and in another because of severe hypotension that was unresponsive to fluids. No change in mean arterial pressure, or vasopressor requirements was noted after the initiation of HFOV. Eight patients died (57 %, 95% CI: 33–79); life support was withdrawn in six and two suffered cardiac arrest. CONCLUSION: During our first year of experience, HFOV was used as a rescue therapy in very sick patients with refractory hypoxemia, and improvement in oxygenation was observed after 24 hours of this technique. HFOV is a reasonable alternative when a protective lung strategy could not be achieved on conventional ventilation