Comparative productivity and structural change in Belgian and Dutch manufacturing:1936-1987

Belgium and The Netherlands share a lot of common characteristics in historical development, geographical location, political and institutional structure and in the size and degree of the openness of their economies. However, detailed comparisons of economic development of Belgium and The Netherlands have been largely neglected until now. This paper presents a comparative description of the development of labour productivity in Belgian and Dutch manufacturing for the period 1921-1990. Three comparative benchmark estimates of output and productivity for the years 1937, 1960 and 1987 were calculated, mainly based on census information. Levels of manufacturing productivity are extended backward and forward by linking time series of productivity change from 1921 to 1990 to the benchmarks.

On a Directed Tree Problem Motivated by a Newly Introduced Graph Product

In this paper we introduce and study a directed tree problem motivated by a new graph product that we have recently introduced and analysed in two conference contributions in the context of periodic real-time processes. While the two conference papers were focussing more on the applications, here we mainly deal with the graph theoretical and computational complexity issues. We show that the directed tree problem is NP-complete and present and compare several heuristics for this problem

Allergen immunotherapy for allergic airway diseases:Use lessons from the past to design a brighter future

Allergic respiratory diseases, such as allergic dermatitis, food allergy, allergic rhino conjunctivitis and allergic asthma, are chronic inflammatory diseases with increasing prevalence. Symptoms include such as watery or itchy itching of the mouth, skin, or the eyes, swelling of the face or throat, sneezing, congestion or vomiting, wheezing, shortness of breath and coughing. For allergic asthma, additional symptoms include tightness of chest, cough, wheezing, and reversible airflow limitation. These symptoms can be triggered by inhalation of aller -gens such as food allergens or airborne allergens such as those from tree-or grass pollen and house dust mites. Pharmacological intervention in allergic disease includes the use of antihistamines, immune suppressive drugs and in case of asthma, the use of (long acting) beta-agonists for relaxation of the constricted airways. These treat-ment options merely suppress symptoms and do not cure the disease. Allergen immunotherapy (AIT), in con -trast, has the capacity of inducing long-term tolerance, with symptom relief persisting decennia after discontinuation of treatment, despite recurrent re-exposure to the allergen. However, AIT is not effective for all allergic disorders, and treatment for several years is required to obtain long-term protection. Moreover, some forms of AIT have safety concerns, with risk of mild to severe allergic reactions. To improve safety and efficacy of AIT, the underlying mechanisms have been studied extensively in the clinic as well as in experimental models of allergic airway inflammation.Despite more than a century of clinical experience and a vast body of experimental and translational studies into the immunological and cellular mechanisms underpinning its therapeutic potential, AIT is still not implemented in routine clinical care for allergic asthma. This review provides an overview of the substantial developments that contribute to our knowledge of the pathogenesis of allergic airway diseases, the mechanism of action of AIT, its treatment routes and schedules, the standardization of extracts and use of adjuvantia. Moreover, the main con-clusions from experimental models of AIT with regard to the safety and effectiveness of the treatment are summarized, and future directions for further improvements are outlined. AIT urgently requires further improvements in order to increase its efficiency and shorten the treatment duration while remaining safe and costeffective.(c) 2022 Published by Elsevier Inc

Late-Holocene Atlantic bottom-water variability in Igaliku Fjord, South Greenland, reconstructed from foraminiferal faunas

A high-resolution record of late-Holocene subsurface water-mass characteristics in outer Igaliku Fjord, South Greenland, is presented based on benthic foraminifera faunas from core PO 243–451 collected from a water depth of 304 m. Strati” cation with Atlantic water masses present in the lower part of the water-column is suggested to have prevailed during the last 3200 cal. years, except for a period referred to as the‘Mediaeval Warm Period’ (MWP). During the MWP (c. ad 885–1235) the outer part of Igaliku Fjord experienced enhanced vertical mixing and a high hydrodynamic energy level which we ascribe to increasing wind stress through this period, corresponding to the period of the Norse settlement. The transition from the MWP to the‘Little Ice Age’ (LIA) shows a two-step pattern with a short climatic amelioration around AD 1520 before maximum cooling occurred. The intensified wind stress and the overall environmental change are suggested to have contributed to the loss of the Norse settlement in Greenland. Periods with strong stratification and marked in uence of Atlantic subsurface water masses around 2.6, 1.3 ka BP and during the LIA are correlated to North Atlantic Holocene ice-rafting events reported by Bond et al. (1997)

Sustainability of participation in collective pension schemes: An option pricing approach

This paper contributes to the discussion about mandatory participation in collective funded pension schemes. It explores under what circumstances individual participants exercise the option to exit such a scheme if participation is voluntary. We begin by showing how the willingness to participate increases if the period over which the option is valid becomes longer. Then, we demonstrate how the pension fund’s set of policy instruments can be deployed to minimize the likelihood that any cohort exits the pension scheme. The instruments consist of contribution and indexation policies. Recovery of the funding ratio, i.e. The ratio of assets over liabilities, to its regulatory target level may be based on uniform contributions or age-dependent contributions. Specifically, while the value of the exit option deters younger workers from exiting the pension fund, a uniform contribution policy encourages older workers to stay in the pension scheme

1,25(OH)2VitD3 supplementation enhances suppression of grass pollen-induced allergic asthma by subcutaneous and sublingual immunotherapy in a mouse model

Allergen specific immunotherapy (AIT) can provide long-term alleviation of symptoms for allergic disease but is hampered by suboptimal efficiency. We and others have previously shown that 1,25(OH)2-VitaminD3 (VitD3) can improve therapeutic efficacy of AIT. However, it is unknown whether VitD3 supplementation has similar effects in sublingual and subcutaneous immunotherapy. Therefore, we aimed to test VitD3 supplementation in both grass pollen (GP) subcutaneous-IT (SCIT) and sublingual-IT (SLIT) in a mouse model for allergic airway inflammation. To this end, GP-sensitized BALB/c mice received GP-SCIT or GP-SLIT with or without 10 ng VitD3, followed by intranasal GP challenges and measurement of airway hyperresponsiveness (AHR) and inflammation. VitD3 supplementation of GP-SCIT resulted in enhanced induction of GP-specific (sp)-IgG2a and suppression of spIgE after challenge. In addition, eosinophil numbers were reduced and levels of IL10 and Amphiregulin were increased in lung tissue. In GP-SLIT, VitD3 supplementation resulted in enhanced sp-IgG2a levels in serum, enhanced suppression of eosinophils and increased IL10 levels in lung tissue, as well as suppression of AHR to methacholine. These data show that VitD3 increases efficacy of both SCIT and SLIT, by enhancing induction of blocking antibodies and suppression of airway inflammation, underscoring the relevance of proficient VitD3 levels for successful AIT

Inhibition of Wnt/beta-Catenin Signaling by p38 MAP Kinase Inhibitors Is Explained by Cross-Reactivity with Casein Kinase I delta/epsilon

SummaryWnt/β-catenin signaling plays essential roles in embryonic development, adult stem cell maintenance, and disease. Screening of a small molecule compound library with a β-galactosidase fragment complementation assay measuring β-catenin nuclear entry revealed TAK-715 and AMG-548 as inhibitors of Wnt-3a-stimulated β-catenin signaling. TAK-715 and AMG-548 are inhibitors of p38 mitogen-activated protein kinase, which has been suggested to regulate activation of Wnt/β-catenin signaling. However, two highly selective and equally potent p38 inhibitors, VX-745 and Scio-469, did not inhibit Wnt-3a-stimulated β-catenin signaling. Profiling of TAK-715 and AMG-548 against a panel of over 200 kinases revealed cross-reactivity with casein kinase Iδ and ɛ, which are known activators of Wnt/β-catenin signaling. Our data demonstrate that this cross-reactivity accounts for the inhibition of β-catenin signaling by TAK-715 and AMG-548 and argue against a role of p38 in Wnt/β-catenin signaling