Clinical Pharmacokinetics, Pharmacodynamics, Safety and Efficacy of Liposomal Amphotericin B

Item does not contain fulltextSince its introduction in the 1990s, liposomal amphotericin B (LAmB) continues to be an important agent for the treatment of invasive fungal diseases caused by a wide variety of yeasts and molds. This liposomal formulation was developed to improve the tolerability of intravenous amphotericin B, while optimizing its clinical efficacy. Since then, numerous clinical studies have been conducted, collecting a comprehensive body of evidence on its efficacy, safety, and tolerability in the preclinical and clinical setting. Nevertheless, insights into the pharmacokinetics and pharmacodynamics of LAmB continue to evolve and can be utilized to develop strategies that optimize efficacy while maintaining the compound's safety. In this article, we review the clinical pharmacokinetics, pharmacodynamics, safety, and efficacy of LAmB in a wide variety of patient populations and in different indications, and provide an assessment of areas with a need for further clinical research

Radiative and Collisional Energy Loss, and Photon-Tagged Jets at RHIC

The suppression of single jets at high transverse momenta in a quark-gluon plasma is studied at RHIC energies, and the additional information provided by a photon tag is included. The energy loss of hard jets traversing through the medium is evaluated in the AMY formalism, by consistently taking into account the contributions from radiative events and from elastic collisions at leading order in the coupling. The strongly-interacting medium in these collisions is modelled with (3+1)-dimensional ideal relativistic hydrodynamics. Putting these ingredients together with a complete set of photon-production processes, we present a calculation of the nuclear modification of single jets and photon-tagged jets at RHIC.Comment: 4 pages, 4 figures, contributed to the 3rd International Conference on Hard and Electro-Magnetic Probes of High-Energy Nuclear Collisions (Hard Probes 2008), typos corrected, published versio

The Sphaleron Rate in SU(N) Gauge Theory

The sphaleron rate is defined as the diffusion constant for topological number NCS = int g^2 F Fdual/32 pi^2. It establishes the rate of equilibration of axial light quark number in QCD and is of interest both in electroweak baryogenesis and possibly in heavy ion collisions. We calculate the weak-coupling behavior of the SU(3) sphaleron rate, as well as making the most sensible extrapolation towards intermediate coupling which we can. We also study the behavior of the sphaleron rate at weak coupling at large Nc.Comment: 18 pages with 3 figure

The Differential Effects of Sleep Quality and Quantity on the Relationship between SES and Health

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73341/1/j.1749-6632.1999.tb08162.x.pd

Electrically Charged Sphalerons

We investigate the possibility that the Higgs sector of the Weinberg-Salam model admits the existence of electrically charged, sphaleron states. Evidence is provided through an asymptotic and numerical perturbative analysis about the uncharged sphaleron. By introducing a toy model in two dimensions we demonstrate that such electrically charged, unstable states can exist. Crucially, they can have a comparable mass to their uncharged counterparts and so may also play a role in electroweak baryogenesis, by opening up new channels for baryon number violating processes.Comment: 12 pages, 4 Postscript figure

Radiative and Collisional Jet Energy Loss in a Quark-Gluon Plasma

We calculate radiative and collisional energy loss of hard partons traversing the quark-gluon plasma created at RHIC and compare the respective size of these contributions. We employ the AMY formalism for radiative energy loss and include additionally energy loss by elastic collisions. Our treatment of both processes is complete at leading order in the coupling, and accounts for the probabilistic nature of jet energy loss. We find that a solution of the Fokker-Planck equation for the probability density distributions of partons is necessary for a complete calculation of the nuclear modification factor $R_{AA}$ for pion production in heavy ion collisions. It is found that the magnitude of $R_{AA}$ is sensitive to the inclusion of both collisional and radiative energy loss, while the average energy is less affected by the addition of collisional contributions. We present a calculation of $R_{AA}$ for $\pi^0$ at RHIC, combining our energy loss formalism with a relativistic (3+1)-dimensional hydrodynamic description of the thermalized medium.Comment: 4 pages, 4 figures, contributed to Quark Matter 2008, Jaipur, Indi

Strong Approximation of Empirical Copula Processes by Gaussian Processes

We provide the strong approximation of empirical copula processes by a Gaussian process. In addition we establish a strong approximation of the smoothed empirical copula processes and a law of iterated logarithm

From lean production to Industrie 4.0: More autonomy for employees?

The article examines the relationship between lean production and Industrie 4.0 focusing on the question of autonomy in the work process. In contrast to the claim made by official Industrie 4.0 concepts that the autonomy of the employees would increase, we see in the current implementation projects a tendency towards greater standardization and control of work. This is in continuity with concepts of lean production, but neglects the participation-oriented elements of lean production such as teamwork and shop-floor-based improvement activities. Our argument is developed by analyzing practical examples from three relevant fields (digital assistance systems, data-based process management, modular assembly). The conclusions of this article also discuss the extent to which the concept of individual autonomy is suitable for the assessment of Industrie 4.0 concepts, given the high levels of interdependence already achieved in production processes

String Equations for the Unitary Matrix Model and the Periodic Flag Manifold

The periodic flag manifold (in the Sato Grassmannian context) description of the modified Korteweg--de Vries hierarchy is used to analyse the translational and scaling self--similar solutions of this hierarchy. These solutions are characterized by the string equations appearing in the double scaling limit of the symmetric unitary matrix model with boundary terms. The moduli space is a double covering of the moduli space in the Sato Grassmannian for the corresponding self--similar solutions of the Korteweg--de Vries hierarchy, i.e. of stable 2D quantum gravity. The potential modified Korteweg--de Vries hierarchy, which can be described in terms of a line bundle over the periodic flag manifold, and its self--similar solutions corresponds to the symmetric unitary matrix model. Now, the moduli space is in one--to--one correspondence with a subset of codimension one of the moduli space in the Sato Grassmannian corresponding to self--similar solutions of the Korteweg--de Vries hierarchy.Comment: 21 pages in LaTeX-AMSTe

Non-Critical Liouville String Escapes Constraints on Generic Models of Quantum Gravity

It has recently been pointed out that generic models of quantum gravity must contend with severe phenomenological constraints imposed by gravitational Cerenkov radiation, neutrino oscillations and the cosmic microwave background radiation. We show how the non-critical Liouville-string model of quantum gravity we have proposed escapes these constraints. It gives energetic particles subluminal velocities, obviating the danger of gravitational Cerenkov radiation. The effect on neutrino propagation is naturally flavour-independent, obviating any impact on oscillation phenomenology. Deviations from the expected black-body spectrum and the effects of time delays and stochastic fluctuations in the propagation of cosmic microwave background photons are negligible, as are their effects on observable spectral lines from high-redshift astrophysical objects.Comment: 15 pages LaTeX, 2 eps figures include