10 research outputs found
Rivaroxaban to prevent major clinical outcomes in non-hospitalised patients with COVID-19 : the CARE â COALITION VIII randomised clinical trial
Background: COVID-19 progression is associated with an increased risk of arterial and venous thrombosis. Randomised trials have demonstrated that anticoagulants reduce the risk of thromboembolism in hospitalised patients with COVID-19, but a benefit of routine anticoagulation has not been demonstrated in the outpatient setting. Methods: We conducted a randomised, open-label, controlled, multicentre study, evaluating the use of rivaroxaban in mild or moderate COVID-19 patients. Adults â„18 years old, with probable or confirmed SARS-CoV-2 infection, presenting within â€7 days from symptom onset with no clear indication for hospitalization, plus at least 2 risk factors for complication, were randomised 1:1 either to rivaroxaban 10 mg OD for 14 days or to routine care. The primary efficacy endpoint was the composite of venous thromboembolic events, need of mechanical ventilation, acute myocardial infarction, stroke, acute limb ischemia, or death due to COVID-19 during the first 30 days. ClinicalTrials.gov: NCT04757857. Findings: Enrollment was prematurely stopped due to sustained reduction in new COVID-19 cases. From September 29th, 2020, through May 23rd, 2022, 660 patients were randomised (median age 61 [Q1-Q3 47â69], 55.7% women). There was no significant difference between rivaroxaban and control in the primary efficacy endpoint (4.3% [14/327] vs 5.8% [19/330], RR 0.74; 95% CI: 0.38â1.46). There was no major bleeding in the control group and 1 in the rivaroxaban group. Interpretation: On light of these findings no decision can be made about the utility of rivaroxaban to improve outcomes in outpatients with COVID-19. Metanalyses data provide no evidence of a benefit of anticoagulant prophylaxis in outpatients with COVID-19. These findings were the result of an underpowered study, therefore should be interpreted with caution
High spirituality score protects against burnout and its consequences among Brazilian cardiologists
South american guidelines for cardiovascular disease prevention and rehabilitation
Resumo nĂŁo disponĂve
Anestesiologia baseada em evidĂȘncias: o que Ă© e como praticar
JUSTIFICATIVA E OBJETIVOS: Os princĂpios da Medicina baseada em evidĂȘncias tĂȘm sido aplicados Ă Anestesiologia. A proposta dessa revisĂŁo Ă© abordar os fundamentos para a prĂĄtica da Medicina baseada em evidĂȘncias e fornecer exemplos de como esses princĂpios podem ser incorporados Ă prĂĄtica diĂĄria. AtĂ© o momento da conclusĂŁo desse artigo, nĂŁo foi encontrado nenhum trabalho sobre Anestesiologia baseada em evidĂȘncias na literatura mĂ©dica brasileira, o que determinou a sua realização. CONTEĂDO: Este artigo consiste de revisĂŁo que aborda um novo paradigma da Medicina e como ele pode ser aplicado Ă Anestesiologia. CONCLUSĂES: A Anestesiologia baseada em evidĂȘncias constitui a integração da melhor evidĂȘncia cientĂfica disponĂvel Ă experiĂȘncia clĂnica do anestesiologista e Ă s expectativas do paciente, visando Ă melhoria do cuidado com ele
Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study
Associations between aplastic anemia and numerous drugs, pesticides and chemicals have been reported. This study conducted in Latin American countries shows a low incidence of aplastic anemia in this region of the world. Frequent exposure to benzene-based products increases this risk, while any association with specific drugs is uncertain