Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice

AbstractCaloric restriction and intermittent fasting are known to improve glucose homeostasis and insulin resistance in several species including humans. The aim of this study was to unravel potential mechanisms by which these interventions improve insulin sensitivity and protect from type 2 diabetes. Diabetes-susceptible New Zealand Obese mice were either 10% calorie restricted (CR) or fasted every other day (IF), and compared to ad libitum (AL) fed control mice. AL mice showed a diabetes prevalence of 43%, whereas mice under CR and IF were completely protected against hyperglycemia. Proteomic analysis of hepatic lipid droplets revealed significantly higher levels of PSMD9 (co-activator Bridge-1), MIF (macrophage migration inhibitor factor), TCEB2 (transcription elongation factor B (SIII), polypeptide 2), ACY1 (aminoacylase 1) and FABP5 (fatty acid binding protein 5), and a marked reduction of GSTA3 (glutathione S-transferase alpha 3) in samples of CR and IF mice. In addition, accumulation of diacylglycerols (DAGs) was significantly reduced in livers of IF mice (P=0.045) while CR mice showed a similar tendency (P=0.062). In particular, 9 DAG species were significantly reduced in response to IF, of which DAG-40:4 and DAG-40:7 also showed significant effects after CR. This was associated with a decreased PKCε activation and might explain the improved insulin sensitivity. In conclusion, our data indicate that protection against diabetes upon caloric restriction and intermittent fasting associates with a modulation of lipid droplet protein composition and reduction of intracellular DAG species

Особенности формирования земельных участков под социальные объекты в сельской местности (д. Лоскутово, п. Светлый Томский район)

Процедура формирования земельных участков под объекты социальных нужд имеет важное практическое значение для Томского района. Автором будут рассмотрены основные этапы проектирования и постановки на кадастровый учет таких земельных участков.The procedure for the formation of land for social needs is of great practical importance for the Tomsk region. The author will consider the main stages of designing and setting up cadastral records of such land plots

Dealing with misleading images: Results from the case study on ‘Muslims in the European Mediascape’

Heeren J, Zick A. Dealing with misleading images: Results from the case study on ‘Muslims in the European Mediascape’. In: Building a Shared Future: The Power of Words and Images. Building a Shared Future. Cambridge: British Council/ HRH Prince Alwaleed Bin Talal Centre of Islamic Studies, University of Cambridge; 2012: 19-20

Misleading Images. Results from Interviews with Media Producers, Journalists and Consumers on Muslims and Islam in German Media

Heeren J, Zick A. Misleading Images. Results from Interviews with Media Producers, Journalists and Consumers on Muslims and Islam in German Media. Middle East Journal of Culture and Communication. 2014;7(1):46-63.As part of the multi-methodological and explorative project ‘Muslims in the European Mediascape’, we conducted focus group interviews with media users of Muslim background. The analysis shows that Muslims in Germany tend to mix media sources in order to get a balanced view on news and current affairs. A large share uses German mainstream media as well as specialized media that cater to the needs and interests of Muslims. The fear of a so-called ‘parallel media society’ of Muslims appears unjustified; however, focus group participants as well as journalists that were also interviewed during the project observed a radicalization of Muslims who were previously indifferent to their religion. Some Muslims seem to have developed a stronger sense of a Muslim identity and loyalty to Muslim communities because they were pushed and encouraged by the often prejudiced media coverage on Muslims and Islam. In this survey of Muslims and non-Muslims we show how the estimation of stereotyped and unbalanced coverage on Muslims and Islam differs among Muslim and non-Muslim media users

Analyseinstrumente zur Prüfung der Konzepttreue einer Online-Beratung

Heeren J, Grau A. Analyseinstrumente zur Prüfung der Konzepttreue einer Online-Beratung. e-beratungsjournal.net. 2013;9(2):1-24.Die Entwicklung einer eigenen, verschriftlichten Konzeption wird als ein Qualitätsmerkmal von Onlineberatungen angesehen. Die tatsächliche Einhaltung des Konzepts scheint dabei vorausgesetzt zu werden, obwohl sie als besonderer Nachweis von Beratungsqualität gelten kann. Vorbilder für die Prüfung einer solchen Konzepttreue von Online-Beratungen fehlen. Im Zuge der wissenschaftlichen Begleitung der Online-Beratung gegen Rechtsextremismus (OBGR) durch das Institut für interdisziplinäre Konflikt- und Gewaltforschung (IKG) der Universität Bielefeld wurde daher ein Instrumentarium aus quantitativen und qualitativen Methoden entwickelt, das sich zum einen eignet, die Einhaltung der Beratungskonzeption zu prüfen, und zum anderen erfasst, wie Klienten die speziellen Kennzeichen der Online-Beratung bewerte

Muslims in the European Mediascape: Germany Country Report

Zick A, Heeren J. Muslims in the European Mediascape: Germany Country Report. Muslims in the European Mediascape. London: Institute for Strategic Dialogue; 2012.The Germany-focused report of the Muslims in the European Mediascape series, written by Jörg Heeren and Andreas Zick

Zusammenfassung der Ergebnisse der wissenschaftlichen Begleitung der Online-Beratung gegen Rechtsextremismus

Grau A, Heeren J, Zick A. Zusammenfassung der Ergebnisse der wissenschaftlichen Begleitung der Online-Beratung gegen Rechtsextremismus. Bielefeld: Institut für interdisziplinäre Konflikt- und Gewaltforschung; 2010

Lernorte der Second-Life-Repräsentanz E-Learning 3D – didaktischer Einsatz und Nutzung für Großgruppen

Heeren J. Lernorte der Second-Life-Repräsentanz E-Learning 3D – didaktischer Einsatz und Nutzung für Großgruppen. In: Andreas S, Nicolas A, eds. Lernen im Digitalen Zeitalter. Dokumentation der Pre-Conference zur DeLFI2009 – Die 7. E-Learning Fachtagung Informatik der Gesellschaft für Informatik e.V. Potsdam/Berlin; 2009: 253-261

Collaborative Learning in Virtual Environments

Schäffer D, Heeren J. Collaborative Learning in Virtual Environments. In: Hebbel-Seeger A, Reiners T, Schäffer D, eds. Synthetic Worlds: Emerging Technologies in Education and Economics. Integrated Series in Information Systems. Vol Volume 33 2014. New York: Springer Science+Business Media; 2013: 295-319.With regard to the increasing demand for facilities that allow self-directed learning, the Department for Educational Sciences at the University of Bielefeld in Germany initiated the project “E-Learning 3D” (EL3) in 2007. The project was designed to develop a virtual learning environment in which students as well as lecturers could interact without actually being on campus. It was expected that such a learning environment could serve as a complementary component of the university’s schedule of lectures. The EL3 project chose the virtual world Second Life (SL) as the infrastructure for the establishment of the required learning spaces. SL is an online-based system which allows the users to move and act in a seemingly three-dimensional space. At the outset of EL3, Second Life was a ubiquitous phenomenon throughout the media. Today, though the medial omnipresence of SL is gone, the number of users is nonetheless still rising. So far, more than 25 million accounts were registered worldwide for the multi-user virtual environment.This article will cover the genesis and decisions made during the process, as well as a description of the employed and adapted learning environments and tools of EL3

Qualitätssicherung im digitalen Lernen – von der Bedarfsanalyse bis zur Evaluation

Heeren J. Qualitätssicherung im digitalen Lernen – von der Bedarfsanalyse bis zur Evaluation. In: Dietl SF, Schmidt H, Weiß R, Wittwer W, eds. AusbilderHandbuch. Vol Aktualisierungslieferung Nr. 220, September 2019. Köln: Deutscher Wirtschaftsdienst; 2019: 1-30