Evidence for cis-eQTL in stimulated <i>versus</i> non-stimulated cells.

<p>For each gene, we plotted the SNP with the lowest <i>P</i> value obtained under an additive model in one condition (stimulated or non-stimulated) against the <i>P</i> value obtained under the alternative condition. Red and grey dashed lines correspond to the 0.01 and to the 0.5 FDR to classify response eQTL (reQTL). Green dots are general cis-eQTL (found in both conditions). Blue dots are reQTL specific to cells stimulated with <i>M</i>. <i>leprae</i> sonicate while pink dots are reQTL specific to untreated cells. For this figure, reQTL are variants that exhibit a significant <i>P</i> value for genotype-phenotype association in one condition at an FDR of 0.01 and not in the other condition at an FDR of 0.5 (without taking the entire 200-kb tested regions per gene into account). The orange cloud corresponds to all the variants detected as being cis-eQTL at an FDR of 0.01.</p

Evidence for cis-eQTL in stimulated <i>versus</i> non-stimulated cells.

<p>For each gene, we plotted the SNP with the lowest <i>P</i> value obtained under an additive model in one condition (stimulated or non-stimulated) against the <i>P</i> value obtained under the alternative condition. Red and grey dashed lines correspond to the 0.01 and to the 0.5 FDR to classify response eQTL (reQTL). Green dots are general cis-eQTL (found in both conditions). Blue dots are reQTL specific to cells stimulated with <i>M</i>. <i>leprae</i> sonicate while pink dots are reQTL specific to untreated cells. For this figure, reQTL are variants that exhibit a significant <i>P</i> value for genotype-phenotype association in one condition at an FDR of 0.01 and not in the other condition at an FDR of 0.5 (without taking the entire 200-kb tested regions per gene into account). The orange cloud corresponds to all the variants detected as being cis-eQTL at an FDR of 0.01.</p

LRRK2 variants preferentially associated with T1R.

<p>LRRK2 variants preferentially associated with T1R.</p

Host versus pathogen control of <i>LRRK2</i> expression levels.

<p><i>LRRK2</i> expression levels for 53 unrelated subjects are indicated on the y-axis and stratified according to rs2404580 genotypes on the x-axis. The left panel represents baseline expression while the right panel indicates gene expression levels following stimulation with <i>M</i>. <i>leprae</i> antigen.</p

Multivariate analysis of <i>LRRK2</i> variants with T1R

<p>Multivariate analysis of <i>LRRK2</i> variants with T1R</p