74 research outputs found
An integration of external information for foreign stallions into the Belgian genetic evaluation for jumping horses
The aim of this study was to test the integration of external information, i.e. foreign estimated breeding values (EBV) and the associated reliabilities (REL), for stallions into the Belgian genetic evaluation for jumping horses. The Belgian model is a bivariate repeatability Best Linear Unbiased Prediction animal model only based on Belgian performances while Belgian breeders import horses from neighbouring countries. Thereby, use of external information is needed as prior to achieve more accurate EBV. Pedigree and performance data contained 101,382 horses and 712,212 performances, respectively. After conversion to the Belgian trait, external information of 98 French and 67 Dutch stallions were integrated into the Belgian evaluation. Resulting Belgian rankings of the foreign stallions were more similar to foreign rankings according to the increase of the rank correlations of at least 12%. REL of their EBV were improved of at least 2% on average. External information was partially to totally equivalent to 4 years of contemporary horses’ performances or to all the stallions’ own performances. All these results showed the interest to integrate external information into the Belgian evaluation
Genetic variance in micro-environmental sensitivity for milk and milk quality in Walloon Holstein cattle
peer reviewedaudience: researcher, professionalAnimals that are robust to environmental changes are desirable in the current dairy industry. Genetic differences in micro-environmental sensitivity can be studied through heterogeneity of residual variance between animals. However, residual variance between animals is usually assumed homogeneous in traditional genetic evaluations. The aim of this study was to investigate genetic heterogeneity of residual variance by estimating variance components in residual variance for milk yield, somatic cell score, contents in milk (g/dL) of two groups of milk fatty acids (i.e. saturated fatty acids and unsaturated fatty acids) and the content in milk of one individual fatty acid (i.e. the oleic acid, C18:1 cis-9), for first-parity Holstein cows in the Walloon Region of Belgium. A total of 146,027 test-day records from 26,887 cows in 747 herds were available. All cows had at least three records and had a known sire. These sires had at least 10 cows with records and each herd x test-day had at least five cows. The five traits were analyzed separately based on fixed lactation curve and random regression test-day models for the mean. Estimation of variance components was performed by running iteratively Expectation Maximization-Restricted Maximum Likelihood algorithm by the implementation of double hierarchical generalized linear models. Based on fixed lactation curve test-day mean models, heritability for residual variances ranged between 1.01*10-3 and 4.17*10-3 for all traits. The genetic standard deviation in residual variance (i.e. approximately the genetic coefficient of variation of residual variance) ranged between 0.12 and 0.17. Therefore, some genetic variance in micro-environmental sensitivity existed in the Walloon Holstein dairy cattle for the five studied traits. The standard deviations due to herd x test-day and permanent environment in residual variance ranged between 0.36 and 0.45 for herd x test-day effect and between 0.55 and 0.97 for permanent environmental effect. Therefore, non-genetic effects also contributed substantially to the micro-environmental sensitivity. Results also showed that the addition of random regressions to the mean model did not reduce heterogeneity in residual variance and that genetic heterogeneity of residual variance was not simply an effect of an incomplete mean model
Sparse single-step genomic blup in crossbreeding schemes
The algorithm for proven and young animals (APY) efficiently computes an approximated inverse of the genomic relationship matrix, by dividing genotyped animals in the so-called core and noncore animals. The APY leads to computationally feasible single-step genomic Best Linear Unbiased Prediction (ssGBLUP) with a large number of genotyped animals and was successfully applied to real single-breed or line datasets. This study aimed to assess the quality of genomic estimated breeding values (GEBV) when using the APY (GEBVAPY), in comparison to GEBV when using the directly inverted genomic relationship matrix (GEBVDIRECT), for situations based on crossbreeding schemes, including F1 and F2 crosses, such as the ones for pigs and chickens. Based on simulations of a 3-way crossbreeding program, we compared different approximated inverses of a genomic relationship matrix, by varying the size and the composition of the core group. We showed that GEBVAPY were accurate approximations of GEBVDIRECT for multivariate ssGBLUP involving different breeds and their crosses. GEBVAPY as accurate as GEBVDIRECT were obtained when the core groups included animals from different breed compositions and when the core groups had a size between the numbers of the largest eigenvalues explaining 98% and 99% of the variation in the raw genomic relationship matrix.</p
Development of a genomic evaluation for milk production for a local bovine breed
DairySN
Estimation of Myostatin gene effects on production traits and fatty acid contents in bovine milk
peer reviewedThe aim of this study was to estimate the genetic parameters of milk, fat, and protein yields, saturated (SFA) and monounsaturated fatty acid (MUFA) contents in bovine milk and to estimate the Myostatin (mh) gene effect on these traits. For this purpose, 51,614 test-day records (24,124, 16,145, and 11,345 for first, second and third lactation, respectively) of 3,098 dual purpose Belgian Blue cows in 38 herds from the Walloon Region of Belgium were used. Because only 2,301 animals, including 1,082 cows with test-day records, were genotyped for mh, the gene content of non-genotyped animals was predicted from animals with a known genotype using the relationships with these animals. Variance components were estimated using Restricted Maximum Likelihood. A 3-lactations, 5-traits random regression test-day mixed model, based on the official Walloon genetic evaluation model for production traits, was used with an additional fixed regression on mh gene content to estimate allele substitution effects. Daily heritability estimates (average of 3 lactations) were 0.34 for SFA and 0.16 for MUFA and were higher than those for production traits (0.11, 0.10, and 0.09 for milk, fat, and protein yields, respectively). Allele substitution effects approximate standard-errors) for mh through the three lactations were-0.628 (+0.343),-0.024 (0.014) and -0.021 (+0.009) kg per day for milk, fat, and protein yields, respectively. Concerning SFA and MUFA contents in milk, the average allele substitution effects were -0.001 (+0.027) and 0.029 (+0.023) g/dl of milk. To conclude, results from this study showed that milk performance traits and milk fatty acid profile are influenced by mh genotypes
International single-step SNPBLUP beef cattle evaluations for Limousin weaning weight
Background Compared to national evaluations, international collaboration projects further improve accuracies of estimated breeding values (EBV) by building larger reference populations or performing a joint evaluation using data (or proxy of them) from different countries. Genomic selection is increasingly adopted in beef cattle, but, to date, the benefits of including genomic information in international evaluations have not been explored. Our objective was to develop an international beef cattle single-step genomic evaluation and investigate its impact on the accuracy and bias of genomic evaluations compared to current pedigree-based evaluations. Methods Weaning weight records were available for 331,593 animals from seven European countries. The pedigree included 519,740 animals. After imputation and quality control, 17,607 genotypes at a density of 57,899 single nucleotide polymorphisms (SNPs) from four countries were available. We implemented two international scenarios where countries were modelled as different correlated traits: an international genomic single-step SNP best linear unbiased prediction (SNPBLUP) evaluation (ssSNPBLUP(INT)) and an international pedigree-based BLUP evaluation (PBLUPINT). Two national scenarios were implemented for pedigree and genomic evaluations using only nationally submitted phenotypes and genotypes. Accuracies, level and dispersion bias of EBV of animals born from 2014 onwards, and increases in population accuracies were estimated using the linear regression method. Results On average across countries, 39 and 17% of sires and maternal-grand-sires with recorded (grand-)offspring across two countries were genotyped. ssSNPBLUP(INT) showed the highest accuracies of EBV and, compared to PBLUPINT, led to increases in population accuracy of 13.7% for direct EBV, and 25.8% for maternal EBV, on average across countries. Increases in population accuracies when moving from national scenarios to ssSNPBLUP(INT) were observed for all countries. Overall, ssSNPBLUP(INT) level and dispersion bias remained similar or slightly reduced compared to PBLUPINT and national scenarios. Conclusions International single-step SNPBLUP evaluations are feasible and lead to higher population accuracies for both large and small countries compared to current international pedigree-based evaluations and national evaluations. These results are likely related to the larger multi-country reference population and the inclusion of phenotypes from relatives recorded in other countries via single-step international evaluations. The proposed international single-step approach can be applied to other traits and breeds
Estimation of myostatin gene effects on production traits and fatty acid contents in bovine milk
peer reviewedThe aim of this study was to estimate the genetic parameters of milk, fat, and protein yields, saturated (SFA) and monounsaturated fatty acid (MUFA) contents in bovine milk and to estimate the Myostatin (mh) gene effect on these traits. For this purpose, 51,614 test-day records (24,124, 16,145, and 11,345 for first, second and third lactation, respectively) of 3,098 dual purpose Belgian Blue cows in 38 herds from the Walloon Region of Belgium were used. Because only 2,301 animals, including 1,082 cows with test-day records, were genotyped for mh, the gene content of non-genotyped animals was predicted from animals with a known genotype using the relationships with these animals. Variance components were estimated using Restricted Maximum Likelihood. A 3-lactations, 5-traits random regression test-day mixed model, based on the official Walloon genetic evaluation model for production traits, was used with an additional fixed regression on mh gene content to estimate allele substitution effects. Daily heritability estimates (average of 3 lactations) were 0.34 for SFA and 0.16 for MUFA and were higher than those for production traits (0.11, 0.10, and 0.09 for milk, fat, and protein yields, respectively). Allele substitution effects approximate standard-errors) for mh through the three lactations were-0.628 (+0.343),-0.024 (0.014) and -0.021 (+0.009) kg per day for milk, fat, and protein yields, respectively. Concerning SFA and MUFA contents in milk, the average allele substitution effects were -0.001 (+0.027) and 0.029 (+0.023) g/dl of milk. To conclude, results from this study showed that milk performance traits and milk fatty acid profile are influenced by mh genotypes
The state of Fortran
A community of developers has formed to modernize the Fortran ecosystem. In this article, we describe the high-level features of Fortran that continue to make it a good choice for scientists and engineers in the 21st century. Ongoing efforts include the development of a Fortran standard library and package manager, the fostering of a friendly and welcoming online community, improved compiler support, and language feature development. The lessons learned are common across contemporary programming languages and help reduce the learning curve and increase adoption of Fortran
Use of high-performance computing in animal breeding
peer reviewedHigh-perfomance computing facilities proposing shared-memory and distributed-memory multiprocessors are becoming available. With those clusters, parallel computing could lead to increased performances and problem sizes. However, to our knowledge and especially for variance components estimations, most software available in animal breeding, based on sparse matrices computations, do not allow parallel computing and are limited by memory accessible by the central processing unit, or allow parallel computing only for options with dense matrices computations, which limits anyway problem sizes due to storage of dense matrices. The aim was to propose simple and effective modifications for the BLUPF90 family of programs to reduce computing time with consideration of required memory. Modifications were based on academic free packages proposing solver and sparse inversion for sparse symmetric indefinite linear systems. First, modifications concerned the sparse inversion subroutine implemented in the package FSPAK. Rearrangements of 'do' loops to allow optimizations of computer operations by some compilers and addition of OpenMP directives were performed. The ordering operation was modified to more easily compare a multiple minimum degree algorithm (MMD; implemented in FSPAK) and a multilevel nested dissection algorithm (implemented in METIS 4.0.3). Second, the package PARDISO Version 5.0.0 was used instead of FSPAK. This package proposes in particular a parallel solver and sparse inversion on shared-memory multiprocessors. Modified FSPAK and PARDISO were compared to original FSPAK using MMD through REMLF90. Different models, such as univariate or bivariate (random regressions) test-day animal and single-step genomic models, were tested. All jobs were run 5 times. With an appropriate ordering algorithm, speedup for each REMLF90 iteration were up to 7.5 for modified FSPAK and up to 22.8 for PARDISO with 2 threads. With 4 threads, speedup increased to 8.3 and 32.5, respectively
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