The Electroweak Phase Transition in Ultra Minimal Technicolor

We unveil the temperature-dependent electroweak phase transition in new extensions of the Standard Model in which the electroweak symmetry is spontaneously broken via strongly coupled, nearly-conformal dynamics achieved by the means of multiple matter representations. In particular, we focus on the low energy effective theory introduced to describe Ultra Minimal Walking Technicolor at the phase transition. Using the one-loop effective potential with ring improvement, we identify regions of parameter space which yield a strong first order transition. A striking feature of the model is the existence of a second phase transition associated to the electroweak-singlet sector. The interplay between these two transitions leads to an extremely rich phase diagram.Comment: 38 RevTeX pages, 9 figure

Nitric oxide mediates interleukin-1 induced inhibition of glycosaminoglycan synthesis in rat articular cartilage

Interleek-1β (IL-1) is a key mediator of cartilage matrix degradation in osteoarthritis and rheumatoid arthritis. It was found that the IL-1-induced suppression of glycosaminoglycan (GAG) synthesis in rat articular cartilage occurred simultaneously with the accumulation of nitrite (a metabolite of nitric oxide (NO) in aqueous milieu) in the culture medium. NO-synthase inhibitors, L-NMMA and L-NIO, inhibited both these IL-1 effects. Dexamethasone suppressed GAG synthesis additively to IL-1, but did not alter nitrite accumulation. Three NO-donors (GEA 3175, SNAP and SIN-1) also had an inhibitory effect on cartilage GAG synthesis. Therefore, it is concluded that IL-1 induced suppression of GAG synthesis in rat articular cartilage is mediated by the production of NO

Continuous data assimilation for global numerical weather prediction

A new configuration of the European Centre for Medium-Range Weather Forecasts (ECMWF) incremental 4D-Var data assimilation (DA) system is introduced which builds upon the quasi-continuous DA concept proposed in the mid-1990s. Rather than working with a fixed set of observations, the new 4D-Var configuration exploits the near-continuous stream of incoming observations by introducing recently arrived observations at each outer loop iteration of the assimilation. This allows the analysis to benefit from more recent observations. Additionally, by decoupling the start time of the DA calculations from the observational data cut-off time, real-time forecasting applications can benefit from more expensive analysis configurations that previously could not have been considered. In this work we present results of a systematic comparison of the performance of a Continuous DA system against that of two more traditional baseline 4D-Var configurations. We show that the quality of the analysis produced by the new, more continuous configuration is comparable to that of a conventional baseline that has access to all of the observations in each of the outer loops, which is a configuration not feasible in real-time operational numerical weather prediction. For real-time forecasting applications, the Continuous DA framework allows configurations which clearly outperform the best available affordable non-continuous configuration. Continuous DA became operational at ECMWF in June 2019 and led to significant 2 to 3% reductions in medium-range forecast root mean square errors, which is roughly equivalent to 2-3 hr of additional predictive skill.Peer reviewe

The use of patient specific polyetheretherketone implants for reconstruction of maxillofacial deformities

Purpose: The aim of this study was to evaluate polyetheretherketone (PEEK) as a patient-specific implant (PSI) material in maxillofacial reconstructive surgery. Materials and methods: The retrospective study included a cohort of 24 patients who underwent maxillofacial surgery using PEEK PSIs. Each patient underwent preoperative multislice computed tomography (CT) with 0 degrees tilt of gantry. Based on the CT scan, the PEEK PSIs were planned and manufactured using three-dimensional (3D) modeling and computer-aided design/computer-aided manufacturing (CAD/CAM) techniques. All procedures were performed under general anesthesia. Implants were placed intraorally, extraorally or through subciliary, transconjuctival or coronal incisions. Results: In 22 of 24 cases, the PEEK PSI fit well without adjustments. Although the fit to the surrounding bone was perfect in almost all of the cases, the outer contour of the PSI was modified in nine cases before fixation. However, intraoperative implant modification did not affect the infection rate. In two cases, postoperative wound dehiscence and infection needed additional treatment and healed without removal of the implants. Conclusion: The follow-up data in this study showed good outcomes with reliable results for PSI made of PEEK in the maxillofacial region. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd.Peer reviewe

Parametric scaling of power exhaust in EU-DEMO alternative divertor simulations

Investigations of parametric scaling of power exhaust in the alternative divertor configuration (ADC) SOLPS-ITER simulation database of the EU-DEMO are conducted and compared to predictions based on the Lengyel model. The Lengyel model overpredicts the necessary argon concentrations for LFS divertor detachment by about a factor of 5-10 relative to the SOLPS-ITER simulations. Therefore, while the Lengyel model predicts that plasmas with accetable divertor heat loads in EU-DEMO would exceed the tolerable upstream impurity concentrations by a large margin, there are several SOLPS-ITER solutions within an acceptable operational space. The SOLPS-ITER simulations indicate that, unlike assumed by the standard Lengyel model, there are significant heat dissipation mechanisms other than argon radiation, such as cross-field transport, that reduce the role of argon radiation by a factor of 2 to 3. Furthermore, the Lengyel model assumes that the radiation front is powered by parallel heat conduction only, which tends to lead to a narrow radiation front as the radiative efficiency increases strongly with reducing thermal conductivity. As a result, the radiative volume and total impurity radiation are suppressed for a given impurity concentration. However, the SOLPS-ITER simulations indicate that other mechanisms, such as cross-field transport, can compete with parallel heat conduction within the radiative front and increase the radiative volume. Due to these findings, usage of the standard Lengyel model for analyzing scaling between divertor conditions and configurations for devices such as EU-DEMO is strongly discouraged

Contact frequency determines outcome of basal insulin initiation trials in type 2 diabetes

Aims/hypothesis The aim of the present study was to investigate whether predetermined contact frequency with the study teamand endpoint insulin dose are associated with study outcomes in basal insulin initiation trials in type 2 diabetes. Methods A systematic Medline search was performed. Using data from the selected studies, contact frequency was plotted against HbA(1c) reduction and endpoint insulin dose. The importance of face-to-face vs telephone contact was also analysed. Insulin dose was plotted against HbA(1c) reduction, hypoglycaemia rate and weight gain. To investigate non-specific study effects, the relationship between contact frequency and HbA(1c) was also assessed in dipeptidyl peptidase-4 (DPP-4) inhibitor trials. Results The reduction in HbA(1c) was highly correlated with contact frequency and endpoint insulin dose (r(2)=0.751, p<0.001 and r(2)=0.433, p=0.008, respectively). However, after adjusting for contact frequency, the relationship between insulin dose and HbA(1c) reduction was no longer significant (p=0.270). The frequency of both clinical and telephone contacts were independent predictors of HbA(1c) improvement (p=0.010 and p<0.001, respectively). We found no dose response relationship between end-of-study insulin dose and hypoglycaemia or weight gain. In DPP-4 inhibitor studies, contact frequency was not positively associated with HbA(1c). Conclusions/interpretation The frequency of contact with the study team is highly correlated with the improvement in HbA(1c) achieved in basal insulin initiation trials in type 2 diabetic patients. This has important implications for trial design and interpretation, as well as for clinical car

C-reactive Protein and Temperament: An Instrumental Variable Analysis

BACKGROUND: Temperament is associated with circulating inflammatory biomarkers, such as C-reactive protein (CRP), which has been associated with various health conditions, including depression. This study aims to investigate whether genetic disposition for increased circulating CRP concentration may influence temperament over the life-course. METHODS: Using a longitudinal cohort that began in 1980—the Cardiovascular Risk in Young Finns Study (YFS)—we included 920 participants (59.8% female) aged 3–12 years old at baseline (childhood), and the same participants again at ages 30–39 years old (adulthood) in this study. We used both ordinary least-squares regression (OLS linear regression) and instrumental variable (IV) regression to assess associations between CRP concentration and temperament dimensions (negative emotionality, activity, and sociability). To represent genetically determined risk for increase in circulating CRP concentration, we calculated a weighted genetic risk score (GRS) which reflects risk for increased circulating CRP concentration. RESULTS: In OLS linear regression analyses, we found that increased circulating CRP concentration in childhood was associated with slightly higher scores for sociability in childhood (19% increase, CI ​= ​7–32%) and adulthood (13% increase, CI ​= ​2–27%), and lower activity scores in adulthood (15% decrease, CI ​= ​3–25%). For all IV regressions, there were no apparent associations between GRS and temperament in either childhood or adulthood (all p>0.3). The Durbin-Wu-Hausman test for endogeneity produced p-values (all>0.05) that suggest there is no evidence for disagreement between the OLS and IV estimates. CONCLUSIONS: We found no clear evidence for an association of GRS for elevated CRP with childhood or adulthood emotionality, activity, or sociability, although circulating CRP was associated with some of these traits

Genetic testing of children for adult-onset conditions: opinions of the British adult population and implications for clinical practice

This study set out to explore the attitudes of a representative sample of the British public towards genetic testing in children to predict disease in the future. We sought opinions about genetic testing for adult-onset conditions for which no prevention/treatment is available during childhood, and about genetic 'carrier' status to assess future reproductive risks. The study also examined participants' level of agreement with the reasons professional organisations give in favour of deferring such testing. Participants (n=2998) completed a specially designed questionnaire, distributed by email. Nearly half of the sample (47%) agreed that parents should be able to test their child for adult-onset conditions, even if there is no treatment or prevention at time of testing. This runs contrary to professional guidance about genetic testing in children. Testing for carrier status was supported by a larger proportion (60%). A child's future ability to decide for her/himself if and when to be tested was the least supported argument in favour of deferring testing.European Journal of Human Genetics advance online publication, 5 November 2014; doi:10.1038/ejhg.2014.221

Role of Poloidal E×B\mathbf{E}\times\mathbf{B} Drift in Divertor Heat Transport in DIII-D

Simulations for DIII-D high confinement mode plasmas with the multifluid code UEDGE show a strong role of poloidal $\mathbf{E}\times\mathbf{B}$ drifts on divertor heat transport, challenging the paradigm of conduction limited scrape-off layer (SOL) transport. While simulations with reduced drift magnitude are well aligned with the assumption that electron heat conduction dominates the SOL heat transport, simulations with drifts predict that the poloidal convective $\mathbf{E}\times\mathbf{B}$ heat transport dominates over electron heat conduction in both attached and detached conditions. Since poloidal $\mathbf{E}\times\mathbf{B}$ flow propagates across magnetic field lines, poloidal transport with shallow magnetic pitch angles can reach values that are of the same order as would be provided by sonic flows parallel to the field lines. These flows can lead to strongly convection dominated divertor heat transport, increasing the poloidal volume of radiative power front, consistent with previous measurements at DIII-D. Due to these convective flows, the Lengyel integral approach, assuming zero convective fraction, is expected to provide a pessimistic estimate for radiative capability of impurities in the divertor. For the DIII-D simulations shown here, the Lengyel integral approach underestimates the radiated power by a factor of 6, indicating that for reliable DIII-D divertor power exhaust predictions, full 2D calculations, including drifts, would be necessary.Comment: Paper submitted into the Contributions to Plasma Physics in the special issue of the 17th International Workshop on Plasma Edge Theory in Fusion Device