68 research outputs found
Evaluation of serum inflammatory biomarkers as predictors of treatment outcome in pulmonary tuberculosis
Symptomatic, biochemical and radiographic recovery in patients with Covid-19
Background: The symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described. Methods: Retrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness. Results: 75.1% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4%. Symptoms and radiographic abnormalities were similar in PCR-positive and PCR-negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5% of patients had unscheduled healthcare visits in the 30 days post discharge. Conclusions: Patients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow-up of patients with COVID-19
Recent developments in protein–ligand affinity mass spectrometry
This review provides an overview of direct and indirect technologies to screen protein–ligand interactions with mass spectrometry. These technologies have as a key feature the selection or affinity purification of ligands in mixtures prior to detection. Specific fields of interest for these technologies are metabolic profiling of bioactive metabolites, natural extract screening, and the screening of libraries for bioactives, such as parallel synthesis libraries and small combichem libraries. The review addresses the principles of each of the methods discussed, with a focus on developments in recent years, and the applicability of the methods to lead generation and development in drug discovery
Community-based dispute resolution processes in Bamiyan province
Deborah J. Smith; Shelly Manala
ENDOGENOUS AND EXOGENOUS AGONIST REGULATION OF RESPONSES TO 0-ADRENOCEPTOR STIMULATION IN PATIENTS WITH CHRONIC AUTONOMIC FAILURE
Pharmacokinetics of intravenously, intramuscularly and intra-adiposely administered carazolol in pigs
Activation of brain calcineurin towards proteins containing Thr(P) and Ser(P) by Ca2+, calmodulin, Mg2+ and transition metal ions
Possible involvement of two proteins (phosphoprotein and CD9(p24)) in regulation of platelet calcium fluxes
Characterization of a high-affinity monoclonal antibody to calcineurin whose epitope defines a new structural domain of calcineurin A
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