Emergence of CD26+ cancer stem cells with metastatic properties in colorectal carcinogenesis

published_or_final_versio

Thermodynamic Geometry and Phase Transitions in Kerr-Newman-AdS Black Holes

We investigate phase transitions and critical phenomena in Kerr-Newman-Anti de Sitter black holes in the framework of the geometry of their equilibrium thermodynamic state space. The scalar curvature of these state space Riemannian geometries is computed in various ensembles. The scalar curvature diverges at the critical point of second order phase transitions for these systems. Remarkably, however, we show that the state space scalar curvature also carries information about the liquid-gas like first order phase transitions and the consequent instabilities and phase coexistence for these black holes. This is encoded in the turning point behavior and the multi-valued branched structure of the scalar curvature in the neighborhood of these first order phase transitions. We re-examine this first for the conventional Van der Waals system, as a preliminary exercise. Subsequently, we study the Kerr-Newman-AdS black holes for a grand canonical and two "mixed" ensembles and establish novel phase structures. The state space scalar curvature bears out our assertion for the first order phase transitions for both the known and the new phase structures, and closely resembles the Van der Waals system.Comment: 1 + 41 pages, LaTeX, 46 figures. Discussions, clarifications and references adde

Logarithmic correction to BH entropy as Noether charge

We consider the role of the type-A trace anomaly in static black hole solutions to semiclassical Einstein equation in four dimensions. Via Wald's Noether charge formalism, we compute the contribution to the entropy coming from the anomaly induced effective action and unveil a logarithmic correction to the Bekenstein-Hawking area law. The corrected entropy is given by a seemingly universal formula involving the coefficient of the type-A trace anomaly, the Euler characteristic of the horizon and the value at the horizon of the solution to the uniformization problem for Q-curvature. Two instances are examined in detail: Schwarzschild and a four-dimensional massless topological black hole. We also find agreement with the logarithmic correction due to one-loop contribution of conformal fields in the Schwarzschild background.Comment: 14 pages, JHEP styl

The holographic principle

There is strong evidence that the area of any surface limits the information content of adjacent spacetime regions, at 10^(69) bits per square meter. We review the developments that have led to the recognition of this entropy bound, placing special emphasis on the quantum properties of black holes. The construction of light-sheets, which associate relevant spacetime regions to any given surface, is discussed in detail. We explain how the bound is tested and demonstrate its validity in a wide range of examples. A universal relation between geometry and information is thus uncovered. It has yet to be explained. The holographic principle asserts that its origin must lie in the number of fundamental degrees of freedom involved in a unified description of spacetime and matter. It must be manifest in an underlying quantum theory of gravity. We survey some successes and challenges in implementing the holographic principle.Comment: 52 pages, 10 figures, invited review for Rev. Mod. Phys; v2: reference adde

Logarithmic Corrections to Extremal Black Hole Entropy from Quantum Entropy Function

We evaluate the one loop determinant of matter multiplet fields of N=4 supergravity in the near horizon geometry of quarter BPS black holes, and use it to calculate logarithmic corrections to the entropy of these black holes using the quantum entropy function formalism. We show that even though individual fields give non-vanishing logarithmic contribution to the entropy, the net contribution from all the fields in the matter multiplet vanishes. Thus logarithmic corrections to the entropy of quarter BPS black holes, if present, must be independent of the number of matter multiplet fields in the theory. This is consistent with the microscopic results. During our analysis we also determine the complete spectrum of small fluctuations of matter multiplet fields in the near horizon geometry.Comment: LaTeX file, 52 pages; v2: minor corrections, references adde

Holographic c-theorems in arbitrary dimensions

We re-examine holographic versions of the c-theorem and entanglement entropy in the context of higher curvature gravity and the AdS/CFT correspondence. We select the gravity theories by tuning the gravitational couplings to eliminate non-unitary operators in the boundary theory and demonstrate that all of these theories obey a holographic c-theorem. In cases where the dual CFT is even-dimensional, we show that the quantity that flows is the central charge associated with the A-type trace anomaly. Here, unlike in conventional holographic constructions with Einstein gravity, we are able to distinguish this quantity from other central charges or the leading coefficient in the entropy density of a thermal bath. In general, we are also able to identify this quantity with the coefficient of a universal contribution to the entanglement entropy in a particular construction. Our results suggest that these coefficients appearing in entanglement entropy play the role of central charges in odd-dimensional CFT's. We conjecture a new c-theorem on the space of odd-dimensional field theories, which extends Cardy's proposal for even dimensions. Beyond holography, we were able to show that for any even-dimensional CFT, the universal coefficient appearing the entanglement entropy which we calculate is precisely the A-type central charge.Comment: 62 pages, 4 figures, few typo's correcte

Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation

10.1371/journal.pgen.1000106PLoS Genetics46

Holographic Derivation of Kerr-Newman Scattering Amplitudes for General Charge and Spin

Near-superradiant scattering of charged scalars and fermions by a near-extreme Kerr-Newman black hole and photons and gravitons by a near-extreme Kerr black hole are computed as certain Fourier transforms of correlators in a two-dimensional conformal field theory. The results agree with the classic spacetime calculations from the 1970s, thereby providing good evidence for a conjectured Kerr-Newman/CFT correspondence.Comment: 22 page