Utilizing data-driven technology tools for community-led solutions to vacant properties and urban blight

As a city that has lost more than 1/3 of its population over the past 6 decades, some Baltimore neighborhoods suffer from a disproportionate number of vacant and abandoned properties, mired in issues of unclear ownership and “under-water” lien burdens. Cloudy legal and financial restrictions cause properties to cycle through a speculative system that strips them of all equity, and causes them to move out of reach for redevelopment. Evidence suggests that existing processes for addressing these issues, such as tax lien sales and foreclosures, can actually play a role in increasing vacancy rates and amplify neighborhood disinvestment (Dewar, Seymour, and Druță, 2015). Policies aimed at real property tax reform and foreclosure prevention can improve conditions, yet communities, non-profits, and city agencies in Baltimore lacked a unified data system to guide their reform and outreach efforts. One challenge is that property data are housed at various agencies, each using its own system of data storage and dissemination, making it difficult to use different datasets for a single property. The Baltimore City Open Land Data (BOLD) web application arose out of the need to streamline the data gathering process by integrating various datasets for easier use by stakeholders working to stabilize their communities, preserve homeownership, and break the cycle of vacant properties. This presentation will give an overview how BOLD was designed, a short demonstration of the application, and show how it can be used to further research the impact of tax sales and foreclosures in Baltimore City

Akt promotes Endocardial-Mesenchyme Transition

Endothelial to mesenchyme transition (EndMT) can be observed during the formation of endocardial cushions from the endocardium, the endothelial lining of the atrioventricular canal (AVC), of the developing heart at embryonic day 9.5 (E9.5). Many regulators of the process have been identified; however, the mechanisms driving the initial commitment decision of endothelial cells to EndMT have been difficult to separate from processes required for mesenchymal proliferation and migration. We have several lines of evidence that suggest a central role for Akt signaling in committing endothelial cells to enter EndMT. Akt1 mRNA was restricted to the endocardium of endocardial cushions while they were forming. The PI3K/Akt signaling pathway is necessary for mesenchyme outgrowth, as sprouting was inhibited in AVC explant cultures treated with the PI3K inhibitor LY294002. Furthermore, endothelial marker, VE-cadherin, was downregulated and mesenchyme markers, N-cadherin and Snail, were induced in response to expression of a constitutively active form of Akt1 (myrAkt1) in endothelial cells. Finally, we isolated the function of Akt1 signaling in the commitment to the transition using a transgenic model where myrAkt1 was pulsed only in endocardial cells and turned off after EndMT initiation. In this way, we determined that increased Akt signaling in the endocardium drives EndMT and discounted its other functions in cushion mesenchymal cells

Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT-SOT Project)

REIPI/INCREMENT-SOT Group.[Background] Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) bloodstream infection (BSI) secondary to urinary tract infection (UTI) in kidney transplant recipients (KTRs) remains unclear.[Methods] We retrospectively evaluated 306 KTR admitted to 30 centers from January 2014 to October 2016. Therapeutic failure (lack of cure or clinical improvement and/or death from any cause) at days 7 and 30 from ESBL-E BSI onset was the primary and secondary study outcomes, respectively.[Results] Therapeutic failure at days 7 and 30 occurred in 8.2% (25/306) and 13.4% (41/306) of patients. Hospital-acquired BSI (adjusted OR [aOR]: 4.10; 95% confidence interval [CI]: 1.50-11.20) and Pitt score (aOR: 1.47; 95% CI: 1.21-1.77) were independently associated with therapeutic failure at day 7. Age-adjusted Charlson Index (aOR: 1.25; 95% CI: 1.05-1.48), Pitt score (aOR: 1.72; 95% CI: 1.35-2.17), and lymphocyte count ≤500 cells/μL at presentation (aOR: 3.16; 95% CI: 1.42-7.06) predicted therapeutic failure at day 30. Carbapenem monotherapy (68.6%, primarily meropenem) was the most frequent active therapy, followed by BLBLI monotherapy (10.8%, mostly piperacillin-tazobactam). Propensity score (PS)-adjusted models revealed no significant impact of the choice of active therapy (carbapenem-containing vs any other regimen, BLBLI- vs carbapenem-based monotherapy) within the first 72 hours on any of the study outcomes.[Conclusions] Our data suggest that active therapy based on BLBLI may be as effective as carbapenem-containing regimens for ESBL-E BSI secondary to UTI in the specific population of KTR. Potential residual confounding and unpowered sample size cannot be excluded (ClinicalTrials.gov identifier: NCT02852902).This work was supported by: (1) Plan Nacional de I+D+i 2013-2016 and Instituto de Salud Carlos III (ISCIII), Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases [RD16/0016/0001, RD16/0016/0002, REIPI RD16/0016/0008; RD16/0016/00010], co-financed by European Development Regional Fund “A way to achieve Europe”, Operative Program Intelligent Growth 2014-2020; (2) European Society of Clinical Microbiology and Infectious diseases Study Group for Infections in Compromised Hosts (ESGICH, grant to J.M.A.); (3) Sociedad Andaluza de Trasplante de Órgano Sólido (SATOT, grant to L.M.M.); (4) Research project PI16/01631 integrated into the Plan Estatal de I+D+I 2013-2016 and co-financed by the ISCIII-Subdirección General de Evaluación y Fomento de la Investigación and the Fondo Europeo de Desarrollo Regional (FEDER); (5) M.F.R. holds a research contract “Miguel Servet” (CP 18/00073) from ISCIII, Ministerio de Ciencia, Innovación y Universidades. The work was also supported by the following European Society of Clinical Microbiology and Infectious diseases (ESCMID) study groups: Infections in Compromised Hosts (ESGICH), Bloodstream Infections and Sepsis (ESGBIS) and Antimicrobial Resistance Surveillance (ESGARS).Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Solstice: An Electronic Journal of Geography and Mathematics, Volume X, Number 1.

This document was delivered over the internet.The purpose of Solstice is to promote interaction between geography and mathematics. Articles in which elements of one discipline are used to shed light on the other are particularly sought. Also welcome, are original contributions that are purely geographical or purely mathematical. These may be prefaced (by editor or author) with commentary suggesting directions that might lead toward the desired interaction. Contributed articles will be refereed by geographers and/or mathematicians. Invited articles will be screened by suitable members of the editorial board. IMaGe is open to having authors suggest, and furnish material for, new regular features.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/2/salt3.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/3/salt2.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/4/salt1.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/5/sols199.htmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/6/1_sols199.htmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/7/wheel.htmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/8/2_sols199.htmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/9/3_sols199.htmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/10/1_wheel.htmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/11/wheel.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/12/2_wheel.htmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/13/solss.gifhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/14/4_sols199.htmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/15/sat.gifhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/16/salt4.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/17/ramp1.gifhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/18/lum.gifhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/19/Image670.gifhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/20/jdn.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/21/Image669.gifhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/22/hue.gifhttp://deepblue.lib.umich.edu/bitstream/2027.42/58276/23/Colorbar.gi