Radiation reaction in the 2.5PN waveform from inspiralling binaries in circular orbits

In this Comment we compute the contributions of the radiation reaction force in the 2.5 post-Newtonian (PN) gravitational wave polarizations for compact binaries in circular orbits. (i) We point out and correct an inconsistency in the derivation of Arun, Blanchet, Iyer, and Qusailah. (ii) We prove that all contributions from radiation reaction in the 2.5PN waveform are actually negligible since they can be absorbed into a modification of the orbital phase at the 5PN order.Comment: 7 pages, no figures, submitted to CQ

Testing post-Newtonian theory with gravitational wave observations

The Laser Interferometric Space Antenna (LISA) will observe supermassive black hole binary mergers with amplitude signal-to-noise ratio of several thousands. We investigate the extent to which such observations afford high-precision tests of Einstein's gravity. We show that LISA provides a unique opportunity to probe the non-linear structure of post-Newtonian theory both in the context of general relativity and its alternatives.Comment: 9 pages, 2 figure

Higher signal harmonics, LISA's angular resolution, and dark energy

It is generally believed that the angular resolution of the Laser Interferometer Space Antenna (LISA) for binary supermassive black holes (SMBH) will not be good enough to identify the host galaxy or galaxy cluster. This conclusion, based on using only the dominant harmonic of the binary SMBH signal, changes substantially when higher signal harmonics are included in assessing the parameter estimation problem. We show that in a subset of the source parameter space the angular resolution increases by more than a factor of 10, thereby making it possible for LISA to identify the host galaxy/galaxy cluster. Thus, LISA's observation of certain binary SMBH coalescence events could constrain the dark energy equation of state to within a few percent, comparable to the level expected from other dark energy missions.Comment: 15 pages, no figures. Final version to appear in Phys. Rev.

MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer.

Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic. Overexpression of the MDR1 gene and corresponding P-glycoprotein (Pgp) is one of the best known MDR mechanisms. MDR1 siRNA based strategies were proposed to circumvent MDR, however, systemic, safe, and effective targeted delivery is still a major challenge. Cluster of differentiation 44 (CD44) targeted hyaluronic acid (HA) based nanoparticle has been shown to successfully deliver chemotherapy agents or siRNAs into tumor cells. The goal of this study is to evaluate the ability of HA-PEI/HA-PEG to deliver MDR1 siRNA and the efficacy of the combination of HA-PEI/HA-PEG/MDR1 siRNA with paclitaxel to suppress growth of ovarian cancer. We observed that HA-PEI/HA-PEG nanoparticles can efficiently deliver MDR1 siRNA into MDR ovarian cancer cells, resulting in down-regulation of MDR1 and Pgp expression. Administration of HA-PEI/HA-PEG/MDR1 siRNA nanoparticles followed by paclitaxel treatment induced a significant inhibitory effect on the tumor growth, decreased Pgp expression and increased apoptosis in MDR ovarian cancer mice model. Our findings suggest that CD44 targeted HA-PEI/HA-PEG/MDR1 siRNA nanoparticles can serve as a therapeutic tool with great potentials to circumvent MDR in ovarian cancer

Probing the non-linear structure of general relativity with black hole binaries

Observations of the inspiral of massive binary black holes (BBH) in the Laser Interferometer Space Antenna (LISA) and stellar mass binary black holes in the European Gravitational-Wave Observatory (EGO) offer an unique opportunity to test the non-linear structure of general relativity. For a binary composed of two non-spinning black holes, the non-linear general relativistic effects depend only on the masses of the constituents. In a recent letter, we explored the possibility of a test to determine all the post-Newtonian coefficients in the gravitational wave-phasing. However, mutual covariances dilute the effectiveness of such a test. In this paper, we propose a more powerful test in which the various post-Newtonian coefficients in the gravitational wave phasing are systematically measured by treating three of them as independent parameters and demanding their mutual consistency. LISA (EGO) will observe BBH inspirals with a signal-to-noise ratio of more than 1000 (100) and thereby test the self-consistency of each of the nine post-Newtonian coefficients that have so-far been computed, by measuring the lower order coefficients to a relative accuracy of $\sim 10^{-5}$ (respectively, $\sim 10^{-4}$) and the higher order coefficients to a relative accuracy in the range $10^{-4}$-0.1 (respectively, $10^{-3}$-1).Comment: 5 pages, 4 figures. Revised version, accepted for publication in Phys. Rev

Inspiralling compact binaries in quasi-elliptical orbits: The complete third post-Newtonian energy flux

The instantaneous contributions to the 3PN gravitational wave luminosity from the inspiral phase of a binary system of compact objects moving in a quasi elliptical orbit is computed using the multipolar post-Minkowskian wave generation formalism. The necessary inputs for this calculation include the 3PN accurate mass quadrupole moment for general orbits and the mass octupole and current quadrupole moments at 2PN. Using the recently obtained 3PN quasi-Keplerian representation of elliptical orbits the flux is averaged over the binary's orbit. Supplementing this by the important hereditary contributions arising from tails, tails-of-tails and tails squared terms calculated in a previous paper, the complete 3PN energy flux is obtained. The final result presented in this paper would be needed for the construction of ready-to-use templates for binaries moving on non-circular orbits, a plausible class of sources not only for the space based detectors like LISA but also for the ground based ones.Comment: 40 pages. Minor changes in text throughout. Minor typos in Eqs. (3.3b), (7.7f), (8.19d) and (8.20) corrected. Matches the published versio

Tail effects in the third post-Newtonian gravitational wave energy flux of compact binaries in quasi-elliptical orbits

The far-zone flux of energy contains hereditary (tail) contributions that depend on the entire past history of the source. Using the multipolar post-Minkowskian wave generation formalism, we propose and implement a semi-analytical method in the frequency domain to compute these contributions from the inspiral phase of a binary system of compact objects moving in quasi-elliptical orbits up to 3PN order. The method explicitly uses the quasi-Keplerian representation of elliptical orbits at 1PN order and exploits the doubly periodic nature of the motion to average the 3PN fluxes over the binary's orbit. Together with the instantaneous (non-tail) contributions evaluated in a companion paper, it provides crucial inputs for the construction of ready-to-use templates for compact binaries moving on quasi-elliptic orbits, an interesting class of sources for the ground based gravitational wave detectors such as LIGO and Virgo as well as space based detectors like LISA.Comment: 32 pages, 10 figures. Minor changes in text throughout. Matches the published versio

\u3cem\u3eMDR1\u3c/em\u3e siRNA Loaded Hyaluronic Acid-Based CD44 Targeted Nanoparticle Systems Circumvent Paclitaxel Resistance in Ovarian Cancer

Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic. Overexpression of the MDR1 gene and corresponding P-glycoprotein (Pgp) is one of the best known MDR mechanisms. MDR1 siRNA based strategies were proposed to circumvent MDR, however, systemic, safe, and effective targeted delivery is still a major challenge. Cluster of differentiation 44 (CD44) targeted hyaluronic acid (HA) based nanoparticle has been shown to successfully deliver chemotherapy agents or siRNAs into tumor cells. The goal of this study is to evaluate the ability of HA-PEI/HA-PEG to deliver MDR1 siRNA and the efficacy of the combination of HA-PEI/HA-PEG/MDR1 siRNA with paclitaxel to suppress growth of ovarian cancer. We observed that HA-PEI/HA-PEG nanoparticles can efficiently deliver MDR1 siRNA into MDR ovarian cancer cells, resulting in down-regulation of MDR1 and Pgp expression. Administration of HA-PEI/HA-PEG/MDR1 siRNA nanoparticles followed by paclitaxel treatment induced a significant inhibitory effect on the tumor growth, decreased Pgp expression and increased apoptosis in MDR ovarian cancer mice model. Our findings suggest that CD44 targeted HA-PEI/HA-PEG/MDR1 siRNA nanoparticles can serve as a therapeutic tool with great potentials to circumvent MDR in ovarian cancer

Parametrized tests of post-Newtonian theory using Advanced LIGO and Einstein Telescope

General relativity has very specific predictions for the gravitational waveforms from inspiralling compact binaries obtained using the post-Newtonian (PN) approximation. We investigate the extent to which the measurement of the PN coefficients, possible with the second generation gravitationalwave detectors such as the Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) and the third generation gravitational-wave detectors such as the Einstein Telescope (ET), could be used to test post-Newtonian theory and to put bounds on a subclass of parametrized-post-Einstein theories which differ from general relativity in a parametrized sense. We demonstrate this possibility by employing the best inspiralling waveform model for nonspinning compact binaries which is 3.5PN accurate in phase and 3PN in amplitude. Within the class of theories considered, Advanced LIGO can test the theory at 1.5PN and thus the leading tail term. Future observations of stellar mass black hole binaries by ET can test the consistency between the various PN coefficients in the gravitational-wave phasing over the mass range of 11-44 Msun. The choice of the lower frequency cut off is important for testing post-Newtonian theory using the ET. The bias in the test arising from the assumption of nonspinning binaries is indicated.Comment: 18 pages, 11 figures, Matches with the published versio

Complete adiabatic waveform templates for a test-mass in the Schwarzschild spacetime: VIRGO and Advanced LIGO studies

Post-Newtonian expansions of the binding energy and gravitational wave flux truncated at the {\it same relative} post-Newtonian order form the basis of the {\it standard adiabatic} approximation to the phasing of gravitational waves from inspiralling compact binaries. Viewed in terms of the dynamics of the binary, the standard approximation is equivalent to neglecting certain conservative post-Newtonian terms in the acceleration. In an earlier work, we had proposed a new {\it complete adiabatic} approximant constructed from the energy and flux functions. At the leading order it employs the 2PN energy function rather than the 0PN one in the standard approximation, so that, effectively the approximation corresponds to the dynamics where there are no missing post-Newtonian terms in the acceleration. In this paper, we compare the overlaps of the standard and complete adiabatic templates with the exact waveform in the adiabatic approximation of a test-mass motion in the Schwarzschild spacetime, for the VIRGO and the Advanced LIGO noise spectra. It is found that the complete adiabatic approximants lead to a remarkable improvement in the {\it effectualness} at lower PN ($<$ 3PN) orders, while standard approximants of order $\geq$ 3PN provide a good lower-bound to the complete approximants for the construction of effectual templates. {\it Faithfulness} of complete approximants is better than that of standard approximants except for a few post-Newtonian orders. Standard and complete approximants beyond the adiabatic approximation are also studied using the Lagrangian templates of Buonanno, Chen and Vallisneri.Comment: Proceedings of the GWDAW-9, Accepted for publication in Class. Quant. Gra