243 research outputs found
Asymmetric synthesis of gonytolide A: strategic use of an aryl halide blocking group for oxidative coupling
The first synthesis of the chromanone lactone dimer gonytolide A has been achieved employing vanadium(V)-mediated oxidative coupling of the monomer gonytolide C. An o-bromine blocking group strategy was employed to favor para- para coupling and to enable kinetic resolution of (±)-gonytolide C. Asymmetric conjugate reduction enabled practical kinetic resolution of a chiral, racemic precursor and the asymmetric synthesis of (+)-gonytolide A and its atropisomer.We thank the National Institutes of Health (R35 GM-118173) for research support. Work at the BU-CMD is supported by NIH R24 Grant GM-111625. We thank Prof. Scott Miller and Dr. Anthony Metrano (Yale University) for helpful discussions and preliminary experiments. We thank the Uehara Memorial Foundation for a postdoctoral fellowship to T.I., the American Cancer Society for a postdoctoral fellowship to K.D.R. (PF-16-235-01-CDD), Dr. Jeffrey Bacon (Boston University) for X-ray crystal structure analyses, and Prof. Haruhisa Kikuchi (Tohoku University) for providing a natural sample of gonytolide A. NMR (CHE-0619339) and MS (CHE-0443618) facilities at Boston University are supported by the NSF. (R35 GM-118173 - National Institutes of Health; GM-111625 - NIH; Uehara Memorial Foundation; PF-16-235-01-CDD - American Cancer Society; CHE-0619339 - NSF; CHE-0443618 - NSF
Stroboscopic oblique-incidence interferometer for motion visualization of stator of ultrasonic motor.
AbstractThis paper describes a motion-visualization technique for an ultrasonic motor (USM) by using a stroboscopic oblique-incidence interferometer. Characteristics of USM depend on a vibration mode of a stator which is one of main component of USM. Though there are some visualization techniques of its vibrated mode, it is difficult to visualization. Because the surface of the stator is rough for a light. For visualization such a surface, we focused on an oblique-incidence interferometer. The interferometer is well suited to analyze the rough surface because a scattering at the rough surface is reduced by using an oblique-incidence light. Furthermore, for detecting a vibrated surface, a pulsed light synchronized with stator was used as light source. We have succeeded to detect a periodically movement of fringe patterns of the vibrated stator
constant pressure expression of power law non-newtonian fluid/solid mixture
Expression is the separation of liquid from a two-phase solid/liquid system by compression due to movement of the retaining wall. Expression of non-Newtonian fluid/solid mixture is often encountered in the fields of polymer and food industries. However, a reliable method for the design of the expression process has not been established. In this study, we conducted expression experiments of non-Newtonian fluid/solid mixture under a constant pressure condition. As a model suspended particle, cellulose or kieselguhr powder was used. The powder was mixed with an aqueous solution of sodium carboxymethyl cellulose or sodium polyacrylate. The mixture was first preconsolidated in the compression-permeability cell that consisted of a cell cylinder and a piston of 6 cm diameter and then expressed under constant pressure. As the expression advanced, the time course of the thickness of the sample was measured by a dial gauge fitted on the cylinder. The basic consolidation equation was derived by combining the fundamental equation for power law non-Newtonian flow in the cake with the equation of continuity, and was solved numerically using the Runge-Kutta method. The progress of the expression is represented by an average consolidation ratio Uc. The agreement between calculated and experimental Uc was
satisfactory when the creep deformation of the material was taken into consideration. It was elucidated that the consolidation time required for attaining a certain degree of primary consolidation depends on the (N+1)/N-th power of the total volume of the solid material , where N is the flow behavior index of the squeezed liquid. On the other hand, the creep constants B, the ratio of creep deformation to the total deformation,
and , a measure of the rate of creep deformation, both were found to be -independent parameters, supporting the validity of the assumption made in the theoretical derivation
Constant pressure expression of power law non-Newtonian fluid/solid mixture
Expression of non-Newtonian fluid/solid mixture is often encountered in the fields of polymer and food industries. However, a reliable method for the design of the expression process has not been established. In this study, we conducted expression experiments of power law non-Newtonian fluid/solid mixture under constant pressure condition. The basic consolidation equation was derived by combining the fundamental equation for power law non-Newtonian flow through the cake with the equation of continuity and solved numerically using the Runge-Kutta method. The progress of the expression is represented by an average consolidation ratio Uc. The agreement between calculated and experimental Uc was satisfactory when the creep deformation of the material was taken into consideration. It was also elucidated that the consolidation time required for attaining a certain degree of primary consolidation depends on the (N+1)/N-th power of the total volume of the solid material omega_0, where N is the flow behavior index of the squeezed liquid. On the other hand, the creep constants B, the ratio of creep deformation to the total deformation, and eta, a measure of the rate of creep deformation, both were found to be omega_0-independent parameters, supporting the validity of the assumption made in the theoretical derivation
Global Thrombosis Test - a possible monitoring system for the effects and safety of dabigatran
© Otsui et al. 2015BACKGROUND: Dabigatran is an alternative to warfarin (WF) for the thromboprophylaxis of stroke in patients with non-valvular atrial fibrillation (NVAF). The advantage of dabigatran over WF is that monitoring is not required; however, a method to monitor the effect and the safety of dabigatran is not currently available. The Global Thrombosis Test (GTT) is a novel method to assess both clot formation and lysis activities under physiological conditions. OBJECTIVE: The aim of this study was to evaluate whether treatment with dabigatran might affect shear-induced thrombi (occlusion time [OT], sec) by the GTT, and to investigate the possibility that the GTT could be useful as a monitoring system for dabigatran. PATIENTS/METHODS: The study population consisted of 50 volunteers and 43 NVAF patients on WF therapy, who were subsequently switched to dabigatran. Using the GTT, the thrombotic status was assessed one day before and 1 month after switching anticoagulation from WF to dabigatran. RESULTS: The OT was 524.9 ± 17.0 sec in volunteers whereas that of NVAF patients on WF therapy was 581.7 ± 26.3 sec. The switch from WF to dabigatran significantly prolonged OT (784.5 ± 19.3 sec). One patient on WF therapy and 12 patients on dabigatran therapy were shown to have OT > 900 sec. CONCLUSION: The GTT could be used to assess the risk of dabigatran-related bleeding complications.Peer reviewe
Involvement of Nitric Oxide in a Rat Model of Carrageenin-Induced Pleurisy
Some evidence indicates that nitric oxide (NO) contributes to inflammation, while other evidence supports the opposite conclusion. To clarify the role of NO in inflammation, we studied carrageenin-induced pleurisy in rats treated with an NO donor (NOC-18), a substrate for NO formation (L-arginine), and/or an NO synthase inhibitor (S-(2-aminoethyl) isothiourea or NG-nitro-L-arginine). We assessed inflammatory cell migration, nitrite/nitrate values, lipid peroxidation and pro-inflammatory mediators. NOC-18 and L-arginine reduced the migration of inflammatory cells and edema, lowered oxidative stress, and normalized antioxidant enzyme activities. NO synthase inhibitors increased the exudate formation and inflammatory cell number, contributed to oxidative stress, induced an oxidant/antioxidant imbalance by maintaining high O2−, and enhanced the production of pro-inflammatory mediators. L-arginine and NOC-18 reversed the proinflammatory effects of NO synthase inhibitors, perhaps by reducing the expression of adhesion molecules on endothelial cells. Thus, our results indicate that NO is involved in blunting—not enhancing—the inflammatory response
Multicascade-linked synthetic wavelength digital holography using an optical-comb-referenced frequency synthesizer
Digital holography (DH) is a promising method for non-contact surface
topography because the reconstructed phase image can visualize the nanometer
unevenness in a sample. However, the axial range of this method is limited to
the range of the optical wavelength due to the phase wrapping ambiguity.
Although the use of two different wavelengths of light and the resulting
synthetic wavelength, i.e., synthetic wavelength DH, can expand the axial range
up to a few tens of microns, this method is still insufficient for practical
applications. In this article, a tunable external cavity laser diode
phase-locked to an optical frequency comb, namely, an optical-comb-referenced
frequency synthesizer, is effectively used for multiple synthetic wavelengths
within the range of 32 um to 1.20 m. A multiple cascade link of the phase
images among an optical wavelength (= 1.520 um) and 5 different synthetic
wavelengths (= 32.39 um, 99.98 um, 400.0 um, 1003 um, and 4021 um) enables the
shape measurement of a reflective millimeter-sized stepped surface with the
axial resolution of 34 nm. The axial dynamic range, defined as the ratio of the
maximum axial range (= 0.60 m) to the axial resolution (= 34 nm), achieves
1.7*10^8, which is much larger than that of previous synthetic wavelength DH.
Such a wide axial dynamic range capability will further expand the application
field of DH for large objects with meter dimensions.Comment: 19 pages, 7 figure
Clinical Performance of a Salivary Amylase Activity Monitor During Hemodialysis Treatment
The hemodialysis procedure is thought to be a physical stressor in the majority of hemodialyzed patients. Previous studies suggest that elevated salivary amylase level may correlate with increased plasma norepinephrine level under psychological and physical stress conditions. In this study, we investigated biological stress reactivity during hemodialysis treatment using salivary amylase activity as a biomarker. Seven patients (male/female = 5/2, age: 67.7+/−5.9 years) who had been receiving regular 4 h hemodialysis were recruited. Salivary amylase activity was measured using a portable analyzer every hour during the hemodialysis session. Salivary amylase activity was shown to be relatively stable and constant throughout hemodialysis, whereas there were significant changes in systolic blood pressure and pulse rate associated with blood volume reduction. Our results show that hemodialysis treatment per se dose not affect salivary amylase activity
Stochastic Geometry Analysis of Individual Carrier Sense Threshold Adaptation in IEEE 802.11ax WLANs
This paper discusses the impact of spatial reuse and carrier sense threshold (CST) optimization on the performance of wireless local area networks using stochastic geometry analysis. The adjustment of the CST is a promising approach to improve spatial reuse, and has been proposed for the IEEE 802.11ax standard. Considering the situation where each access point (AP) individually adjusts its CST based on the individual received power, this paper derives the probability of transmission success and the density of successful transmissions (DST). The evaluation results of these metrics reveal that the optimal setting is to increase the CST linearly (in terms of dB) with respect to the average received signal power. Because the maximization of the DST causes unfairness from the viewpoint of success of transmission, the maximization of the product of the transmission success probabilities is proposed to improve the performance of the entire system and restrain unfairness. Using the trend of the optimal CST function, the impact of the density of APs on the optimal CST function is determined. Moreover, individual CST adjustment is found to improve spatial reuse compared with identical adjustment, i.e., setting the CST of all APs to an identical value
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