"Homeless Networks and Geographic Concentration: Evidence from Osaka City"

Homeless people in Osaka City are geographically concentrated. The purpose of this paper is to examine this geographic concentration by focusing on homeless networks. The data we use contain information on Osaka City.s homeless population by census blocks. The estimated results of a spatial autoregressive model with autoregressive disturbances show that the homeless network is signi.cantly positive across census blocks. Networks exist in a homeless society.

"Homeless Networks: Testing Peer and Homed Networks Against Location Choice"

This paper examines the location choices of homeless people in Osaka City, and .nds them concentrated because of homeless networks. The paper also shows that different types of homeless networks operate in two different homeless groups: (1) peer networks that provide a social tie inside homeless communities are observed in groups that had not had work experience in the day labor market; (2) homed networks that provide a social tie outside homeless communities affect location choice in the expected way, although the effect is statistically insigni.cant in groups that had worked in the day labor market.

Homeless Networks: Testing Peer and Homed Networks Against Location Choice.

This paper examines the location choices of homeless people in Osaka City, and finds them concentrated because of homeless networks. The paper also shows that different types of homeless networks operate in two different homeless groups: (1) peer networks that provide a social tie inside homeless communities are observed in groups that had not had work experience in the day labor market; (2) homed networks that provide a social tie outside homeless communities affect location choice in the expected way, although the effect is statistically insignificant in groups that had worked in the day labor market

Homeless Networks and Geographic Concentration: Evidence from Osaka City

Homeless people in Osaka City are geographically concentrated. The purpose of this paper is to examine this geographic concentration by focusing on homeless networks. The data we use contain information on Osaka City\u27s homeless population by census blocks. The estimated results of a spatial autoregressive model with autoregressive disturbances show that the homeless network is significantly positive across census blocks. Networks exist in a homeless society

The complete chloroplast genome of a coastal plant, Euphorbia jolkinii (Euphorbiaceae)

The complete chloroplast genome sequence of a coastal plant, Euphorbia jolkinii Boiss. (Euphorbiaceae), was determined. The chloroplast genome was 162, 854 bp in length, consisting of a large single copy region (90, 726 bp), a small single copy region (18, 422 bp), and two inverted repeats (26, 853 bp). The chloroplast genome contained 115 genes, consisting of 80 unique protein-coding genes, 30 unique tRNA genes, four unique rRNA genes, and one pseudogene, rps16. GC content of the whole chloroplast genome was 35.6%. The phylogenetic analysis showed a close relationship between E. jolkinii and E. pekinensis Rupr. The sequence data would provide useful information to understand the evolutionary process of E. jolkinii

Behavioural differences between breeding and nonbreeding pairs of protandry monogamous false clown anemonefish Amphiprion ocellaris

Anemonefishes are some of the most popular marine ornamental fishes. Due to the adverse impacts of commercial fishing on the wild populations of anemonefishes, a more suitable and efficient captive breeding programme must be promoted. In the wild, anemonefishes are protandrous sex-changing fish, but when two immature individuals with ambisexual gonads are raised together in captivity, the two differentiate directly into a male and a female, to form a breeding pair. However, not all the formed pairs spawn, explaining the great care required in captive breeding. This behaviour appears to be counter-adaptative, as anemonefish social groups form randomly in the wild, and such phenomenon would disturb their breeding success. This study evaluated the behavioural and physiological differences between breeding and nonbreeding pairs of false clown anemonefish Amphiprion ocellaris under captive conditions. Behavioural observations revealed that nonbreeding females monopolized the shelter provided, whereas breeding females allowed breeding males to use the shelter and the pair frequently stayed together in the shelter. Both nonbreeding and breeding females possessed mature ovarian tissue and similar level of plasma estradiol concentrations, but nonbreeding males had a smaller amount of testicular tissue and lower plasma 11-ketotestosterone levels compared to breeding males

Liquid Biopsy Targeting Monocarboxylate Transporter 1 on the Surface Membrane of Tumor-Derived Extracellular Vesicles from Synovial Sarcoma

Simple Summary Synovial sarcoma (SS) is associated with a high risk of recurrence and poor prognosis, and no biomarker useful in monitoring tumor burden exists. We identified monocarboxylate transporter 1 (MCT1) expressed in extracellular vesicles (EVs) derived from synovial sarcoma as a potential such marker. Circulating levels of MCT1(+)CD9(+) EVs were significantly correlated with tumor volume in a SS mouse model. Serum levels of MCT1(+)CD9(+) EVs reflected tumor burden and treatment response in SS patients. Patients with MCT1 expression on the plasma membrane have significantly worse overall survival than those with nuclear expression. Silencing of MCT1 reduced the malignant phenotype including cellular viability, migration, and invasion of SS cells. MCT1 may thus be a promising novel target for liquid biopsies and a novel therapeutic target. The lack of noninvasive biomarkers that can be used for tumor monitoring is a major problem for soft-tissue sarcomas. Here we describe a sensitive analytical technique for tumor monitoring by detecting circulating extracellular vesicles (EVs) of patients with synovial sarcoma (SS). The proteomic analysis of purified EVs from SYO-1, HS-SY-II, and YaFuSS identified 199 common proteins. DAVID GO analysis identified monocarboxylate transporter 1 (MCT1) as a surface marker of SS-derived EVs, which was also highly expressed in SS patient-derived EVs compared with healthy individuals. MCT1(+)CD9(+) EVs were also detected from SS-bearing mice and their expression levels were significantly correlated with tumor volume (p = 0.003). Furthermore, serum levels of MCT1(+)CD9(+) EVs reflected tumor burden in SS patients. Immunohistochemistry revealed that MCT1 was positive in 96.7% of SS specimens and its expression on the cytoplasm/plasma membrane was significantly associated with worse overall survival (p = 0.002). Silencing of MCT1 reduced the cellular viability, and migration and invasion capability of SS cells. This work describes a new liquid biopsy technique to sensitively monitor SS using circulating MCT1(+)CD9(+) EVs and indicates the therapeutic potential of MCT1 in SS