Gluon Propagators and Confinement

We present SU(3) gluon propagators calculated on 48*48*48*N_t lattices at beta=6.8 where N_t=64 (corresponding the confinement phase) and N_t=16 (deconfinement) with the bare gauge parameter,alpha, set to be 0.1. In order to avoid Gribov copies, we employ the stochastic gauge fixing algorithm. Gluon propagators show quite different behavior from those of massless gauge fields: (1) In the confinement phase, G(t) shows massless behavior at small and large t, while around 5<t<15 it behaves as massive particle, and (2) effective mass observed in G(z) becomes larger as z increases. (3) In the deconfinement phase, G(z) shows also massive behavior but effective mass is less than in the confinement case. In all cases, slope masses are increasing functions of t or z, which can not be understood as addtional physical poles.Comment: 6 pages in Postscrip

Sacubitril/valsartan attenuates atrial conduction disturbance and electrophysiological heterogeneity with ameliorating fibrosis in mice

BackgroundSacubitril/valsartan (SacVal) has been shown to improve the prognosis of heart failure; however, whether SacVal reduces the occurrence of atrial fibrillation (AF) in heart failure has not yet been elucidated. In this study, we aimed to determine whether SacVal is effective in reducing the occurrence of AF in heart failure and identify the underlying mechanism of its electrophysiological effect in mice.MethodsAdult male mice underwent transverse aortic constriction, followed by SacVal, valsartan, or vehicle treatment for two weeks. Electrophysiological study (EPS) and optical mapping were performed to assess the susceptibility to AF and the atrial conduction properties, and fibrosis was investigated using heart tissue and isolated cardiac fibroblasts (CFs).ResultsEPS analysis revealed that AF was significantly less inducible in SacVal-treated mice than in vehicle-treated mice. Optical mapping of the atrium showed that SacVal-treated and valsartan-treated mice restored the prolonged action potential duration (APD); however, only SacVal-treated mice showed the restoration of decreased conduction velocity (CV) compared to vehicle-treated mice. In addition, the electrophysiological distribution analysis demonstrated that heterogeneous electrophysiological properties were rate-dependent and increased heterogeneity was closely related to the susceptibility to AF. SacVal attenuated the increased heterogeneity of CV at short pacing cycle length in atria, whereas Val could not. Histological and molecular evaluation showed that SacVal exerted the anti-fibrotic effect on the atria. An in vitro study of CFs treated with natriuretic peptides and LBQ657, the metabolite and active form of sacubitril, revealed that C-type natriuretic peptide (CNP) combined with LBQ657 had an additional anti-fibrotic effect on CFs.ConclusionsOur results demonstrated that SacVal can improve the conduction disturbance and heterogeneity through the attenuation of fibrosis in murine atria and reduce the susceptibility of AF in heart failure with pressure overload, which might be attributed to the enhanced function of CNP

Tg動物飼育システムSTAR及びSTAR/OKの紹介

Transgenic animal research is progressing in recent years. Severer cross-contamination prevention management is required for breeding transgenic animals in clean environment, like SPF animals. Moreover, contaminants and odors problems have posed the more serious influence to caretakers or researchers. In order that we might improve these problems, we got cooperation of Kumamoto University and developed the rack (STAR: System of Tonets Animal Rack)for transgenic animal research that have both the supply air-inlet and the exhaust air-outlet. If this system is used, the good experiment is possible that does not have a cross-contamination between cages and does not have diffusion contaminants and odors to an animal room. In this paper, we introduce also about the Okayama University specification (STAR/OK) as the application

The Fantastic Four: A plug 'n' play set of optimal control pulses for enhancing nmr spectroscopy

We present highly robust, optimal control-based shaped pulses designed to replace all 90{\deg} and 180{\deg} hard pulses in a given pulse sequence for improved performance. Special attention was devoted to ensuring that the pulses can be simply substituted in a one-to-one fashion for the original hard pulses without any additional modification of the existing sequence. The set of four pulses for each nucleus therefore consists of 90{\deg} and 180{\deg} point-to-point (PP) and universal rotation (UR) pulses of identical duration. These 1 ms pulses provide uniform performance over resonance offsets of 20 kHz (1H) and 35 kHz (13C) and tolerate reasonably large radio frequency (RF) inhomogeneity/miscalibration of (+/-)15% (1H) and (+/-)10% (13C), making them especially suitable for NMR of small-to-medium-sized molecules (for which relaxation effects during the pulse are negligible) at an accessible and widely utilized spectrometer field strength of 600 MHz. The experimental performance of conventional hard-pulse sequences is shown to be greatly improved by incorporating the new pulses, each set referred to as the Fantastic Four (Fanta4).Comment: 28 pages, 19 figure