Preexisting fractures and the formation of an iconic American landscape: Tuolumne Meadows, Yosemite National Park, USA

Tuolumne Meadows, in Yosemite National Park (USA), is a large sub-alpine meadow in the Sierra Nevada Mountains. Immediately adjacent to Tuolumne Meadows—and underlain by the same bedrock lithology (Cathedral Peak Granodiorite)—are vertical rock faces that provide exceptional opportunities to climbers. While the presence of a broad meadow suggests bedrock erodibility, the vertical rock walls indicate bedrock durability. We propose that the Tuolumne Meadows’s landscape is the result of variable glacial erosion due to the presence or absence of pre-existing bedrock fractures. The meadows and valleys formed because of concentrated tabular fracture clusters—a distinctive and locally pervasive type of fracturing—that were particularly susceptible to glacial erosion. In contrast, the vertical rock walls consist of sparsely fractured bedrock that was originally bounded by zones of pervasive tabular fracture clusters. Glacial erosion preferentially removed the highly fractured rock, forming prominent ridges in the upland surrounding Tuolumne Meadows. The orientation and spacing of the tabular fracture clusters, relative to ice flow, has exerted a fundamental control on the geomorphology of the area. The erosional variability exhibited by a single lithology indicates that the degree of fracturing can be more important than the host lithology in controlling landscape evolution

Memory-card vowel training for child and adult second-language learners: A first report

Japanese adults and Spanish-Catalan children received auditory phonetic training for English vowels using a novel paradigm, a version of the common children's card game Concentration. Individuals played a computer-based game in which they turned over pairs of cards to match spoken words, drawn from sets of vowel minimal pairs. The training was effective for adults, improving vowel recognition in a game that did not explicitly require identification. Children likewise improved over time on the memory card game, but not on the present generalisation task. This gamified training method can serve as a platform for examining development and perceptual learning

Orthogonal parallel processing in vector pascal

Despite the widespread adoption of parallel operations in contemporary CPU designs, their use has been restricted by a lack of appropriate programming language abstractions and development environments. To fully exploit the SIMD model of computation such operations offer, programmers depend on CPU specific machine code or implementation dependent libraries. Vector Pascal is a language designed to enable the elegant and efficient expression of SIMD algorithms. It imports into Pascal abstraction mechanisms derived from functional languages, in turn having their origins in APL. In particular, it extends all operators to work on vectors of data. The type system is also extended to handle pixels and dimensional analysis. Code generation is via the ILCG system that allows retargeting to multiple different SIMD instruction sets based on formalised descriptions of the instruction set semantics

Glacier slip and seismicity induced by surface melt

Many of the key processes governing fast glacier flow involve interaction between a glacier and its basal hydrological system, which is hidden from direct observation. Passive seismic monitoring has shown promise as a tool for remotely monitoring basal processes, but lack of glacier-bed access prevents clear understanding of the relationships between subglacial processes and corresponding seismic emissions. Here we describe direct measurements of basal hydrology, sliding, and broadband seismicity made in a unique subglacial facility in Norway during the onset of two summer melt seasons. In the most pronounced of these episodes, rapid delivery of surface meltwater to the bed briefly enhanced basal slip following a period of elevated high-frequency seismic activity related to surface crevassing. Subsequent ground tilt derived from ultralong-period seismic signals was associated with subglacial bedrock deformation during transient pressurization of the basal hydraulic system. These signals are interpreted to represent hydraulic jacking as the supply of water to the bed exceeded the capacity of the hydraulic system. Enhanced slip terminated 2.5 h after it started, when ice-bed decoupling or increased connectivity in the basal cavity network relieved cavity overpressure. The results support theoretical models for hydraulic jacking and illustrate how melt-induced increases in speed can be short lived if cavity growth or ice-bed decoupling allows basal water more efficient drainage

Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection.

Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis. Both streptococcal species express a serine-rich repeat surface adhesin that mediates attachment to sialylated glycans on mucin-like glycoproteins, but the specific sialoglycan structures recognized can vary from strain to strain. Previous studies have shown that sialoglycan binding is clearly important for aortic valve infections caused by some S. gordonii, but this process did not contribute to the virulence of a strain of S. sanguinis. However, these streptococci can bind to different subsets of sialoglycan structures. Here we generated isogenic strains of S. gordonii that differ only in the type and range of sialoglycan structures to which they adhere and examined whether this rendered them more or less virulent in a rat model of endocarditis. The findings indicate that the recognition of specific sialoglycans can either enhance or diminish pathogenicity. Binding to sialyllactosamine reduces the initial colonization of mechanically-damaged aortic valves, whereas binding to the closely-related trisaccharide sialyl T-antigen promotes higher bacterial densities in valve tissue 72 hours later. A surprising finding was that the initial attachment of streptococci to aortic valves was inversely proportional to the affinity of each strain for platelets, suggesting that binding to platelets circulating in the blood may divert bacteria away from the endocardial surface. Importantly, we found that human and rat platelet GPIbα (the major receptor for S. gordonii and S. sanguinis on platelets) display similar O-glycan structures, comprised mainly of a di-sialylated core 2 hexasaccharide, although the rat GPIbα has a more heterogenous composition of modified sialic acids. The combined results suggest that streptococcal interaction with a minor O-glycan on GPIbα may be more important than the over-all affinity for GPIbα for pathogenic effects

Multiple prior concussions are associated with symptoms in high school athletes

Objectives: The purpose of this study was to evaluate the association of prior concussion on baseline computerized neurocognitive testing in a large cohort of high school athletes. Methods: This is a retrospective cohort study of student athletes from 49 Maine High Schools in 2010 who underwent baseline computerized neurocognitive evaluation with Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT®). As part of the ImPACT®, subjects reported a prior history of concussion as well as demographic information and a symptom questionnaire. We used linear regression to evaluate the association of prior concussion with baseline: (1) ImPACT® composite scores; and (2) symptom scores. Results: Six thousand seventy-five subjects were included in the study, of whom 57% were boys. The majority of student athletes (85.3%) reported no prior history of concussion while 4.6% reported having sustained two or more prior concussions. On simple linear regression, increasing number of concussions was related to worse performance in verbal memory (P = 0.039) and greater symptoms scores (P < 0.001). On multivariate modeling, only the association with baseline symptoms remained (P < 0.001). Other factors associated with baseline symptom reporting in the multivariate model included mental health history, headache/migraine history, gender, developmental and/or learning problems, and number of prior concussions. Interpretation In this large-scale, retrospective survey study, history of multiple prior concussions was associated with higher symptom burden but not baseline computerized neurocognitive testing. The association between baseline symptom reporting and clinical and demographic factors was greater than the association with a history of multiple concussions

Examining Criteria for Defining Persistent Post-Concussion Symptoms in Children and Adolescents

Researchers operationalize persistent post-concussion symptoms in children and adolescents using varied definitions. Many pre-existing conditions, personal characteristics, and current health issues can affect symptom endorsement rates in the absence of, or in combination with, a recent concussion, and the use of varied definitions can lead to differences in conclusions about persistent symptoms and recovery across studies. This study examined how endorsement rates varied by 14 different operational definitions of persistent post-concussion symptoms for uninjured boys and girls with and without pre-existing or current health problems. This cross-sectional study included a large sample (age range: 11–18) of girls (n = 21,923) and boys (n = 26,556) without a recent concussion who completed the Post-Concussion Symptom Scale at preseason baseline. Endorsements rates varied substantially by definition, health history, and current health issues. The most lenient definition (i.e., a single mild symptom) was endorsed by most participants (54.5% of boys/65.3% of girls). A large portion of participants with pre-existing mental health problems (42.7% of boys/51.5% of girls), current moderate psychological distress (70.9% of boys/72.4% of girls), and insufficient sleep prior to testing (33.4% of boys/47.6% of girls) endorsed symptoms consistent with mild ICD-10 postconcussional syndrome; whereas participants with no current or prior health problems rarely met this definition (1.6% of boys/1.6% of girls). The results illustrate the tremendous variability in the case definitions of persistent symptoms and the importance of harmonizing definitions across future studies

Dialectal effects on the perception of Greek vowels

This study examined cross-dialectal differences on the perception of Greek vowels. Speakers of Standard Modern Greek (SMG) and two dialectal areas (Crete, Kozani), all with five vowels in their systems, chose best exemplar locations (prototypes) for Greek vowels embedded in a carrier sentence spoken by a speaker of their dialect. The results showed that SMG, Cretan and Kozani vowels were well separated in the perceptual space. At the same time, there were dialect-induced differences in the positioning and distances between vowels as well as in the total space area covered by each dialect. The organisation of perceived vowel space therefore seems to be dialect-specific, a finding which is consistent with production studies examining the organisation of the acoustic vowel space