Clips: a capacity and lead time integrated procedure for scheduling.

We propose a general procedure to address real life job shop scheduling problems. The shop typically produces a variety of products, each with its own arrival stream, its own route through the shop and a given customer due date. The procedure first determines the manufacturing lot sizes for each product. The objective is to minimize the expected lead time and therefore we model the production environment as a queueing network. Given these lead times, release dates are set dynamically. This in turn creates a time window for every manufacturing order in which the various operations have to be sequenced. The sequencing logic is based on a Extended Shifting Bottleneck Procedure. These three major decisions are next incorporated into a four phase hierarchical operational implementation scheme. A small numerical example is used to illustrate the methodology. The final objective however is to develop a procedure that is useful for large, real life shops. We therefore report on a real life application.Model; Models; Applications; Product; Scheduling;

Identification of Intracellular and Plasma Membrane Calcium Channel Homologues in Pathogenic Parasites

Ca2+ channels regulate many crucial processes within cells and their abnormal activity can be damaging to cell survival, suggesting that they might represent attractive therapeutic targets in pathogenic organisms. Parasitic diseases such as malaria, leishmaniasis, trypanosomiasis and schistosomiasis are responsible for millions of deaths each year worldwide. The genomes of many pathogenic parasites have recently been sequenced, opening the way for rational design of targeted therapies. We analyzed genomes of pathogenic protozoan parasites as well as the genome of Schistosoma mansoni, and show the existence within them of genes encoding homologues of mammalian intracellular Ca2+ release channels: inositol 1,4,5-trisphosphate receptors (IP3Rs), ryanodine receptors (RyRs), two-pore Ca2+ channels (TPCs) and intracellular transient receptor potential (Trp) channels. The genomes of Trypanosoma, Leishmania and S. mansoni parasites encode IP3R/RyR and Trp channel homologues, and that of S. mansoni additionally encodes a TPC homologue. In contrast, apicomplexan parasites lack genes encoding IP3R/RyR homologues and possess only genes encoding TPC and Trp channel homologues (Toxoplasma gondii) or Trp channel homologues alone. The genomes of parasites also encode homologues of mammalian Ca2+ influx channels, including voltage-gated Ca2+ channels and plasma membrane Trp channels. The genome of S. mansoni also encodes Orai Ca2+ channel and STIM Ca2+ sensor homologues, suggesting that store-operated Ca2+ entry may occur in this parasite. Many anti-parasitic agents alter parasite Ca2+ homeostasis and some are known modulators of mammalian Ca2+ channels, suggesting that parasite Ca2+ channel homologues might be the targets of some current anti-parasitic drugs. Differences between human and parasite Ca2+ channels suggest that pathogen-specific targeting of these channels may be an attractive therapeutic prospect

Extending the shifting bottleneck procedure to real-life applications

status: publishe

Clips: a capacity and lead time integrated procedure for scheduling

We propose a general procedure to address real life job shop scheduling problems. The shop typically produces a variety of products, each with its own arrival stream, its own route through the shop and a given customer due date. The procedure first determines the manufacturing lot sizes for each product. The objective is to minimize the expected lead time and therefore we model the production environment as a queueing network. Given these lead times, release dates are set dynamically. This in turn creates a time window for every manufacturing order in which the various operations have to be sequenced. The sequencing logic is based on a Extended Shifting Bottleneck Procedure. These three major decisions are next incorporated into a four phase hierarchical operational implementation scheme. A small numerical example is used to illustrate the methodology. The final objective however is to develop a procedure that is useful for large, real life shops. We therefore report on a real life application.status: publishe

Een innovatieve aanpak voorproductie. Over doorlooptijden, snel reactievermogen en een betere competitieve positie

status: publishe

Weak evidence of regeneration habitat but strong evidence of regeneration niche for a leguminous shrub

The identification of an ecological niche specific to the regeneration phase has mobilised significant attention. However, the importance of the regeneration niche concept remains unclear. Our main objective was to study the existence of such a regeneration niche for a leguminous shrub, Ulex europaeus. This study was carried out in southwest France in the context of water and nutrient stresses (mainly phosphorus limitation) due to the presence of nutrient-poor sandy soils. We analysed the regeneration of the species from the germination of seeds and emergence of new seedlings until the seedlings reached young shrub size. Our design included a P fertilisation treatment. We also investigated microsite characteristics (micro-topography and vegetation development) as they can interact with meteorological conditions and determine water availability for seeds and seedlings. We found that P availability controlled seedling growth and the time necessary to reach young shrub size. Water availability appeared to impact the species germination and seedlings survival. We also found that P and water availability depended on the interactions between microsite characteristics and climatic variations. Finally we found evidence that P and water availability are important ecological factors shaping the regeneration niche of the species, but we found weak evidence that any microsite would be appropriate for the regeneration of the species in the long term. Future studies regarding regeneration niches need to distinguish more clearly the ecological factors important for regeneration (the regeneration niche per se) and the physical world where the seedlings appear and develop (the regeneration habitat)