310 research outputs found

    Reducible connections and non-local symmetries of the self-dual Yang-Mills equations

    Get PDF
    We construct the most general reducible connection that satisfies the self-dual Yang-Mills equations on a simply connected, open subset of flat R4\mathbb{R}^4. We show how all such connections lie in the orbit of the flat connection on R4\mathbb{R}^4 under the action of non-local symmetries of the self-dual Yang-Mills equations. Such connections fit naturally inside a larger class of solutions to the self-dual Yang-Mills equations that are analogous to harmonic maps of finite type.Comment: AMSLatex, 15 pages, no figures. Corrected in line with the referee's comments. In particular, restriction to simply-connected open sets now explicitly stated. Version to appear in Communications in Mathematical Physic

    Ассоциация ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… Π²Π°Ρ€ΠΈΠ°Π½Ρ‚ΠΎΠ² Π³Π΅Π½Π° ΠΌΠΎΠ·Π³ΠΎΠ²ΠΎΠ³ΠΎ нСйротрофичСского Ρ„Π°ΠΊΡ‚ΠΎΡ€Π° (BDNF rs6265) ΠΈ Π³Π΅Π½Π° пСрСносчика Π³Π»ΡƒΡ‚Π°ΠΌΠ°Ρ‚Π° Π²Ρ‚ΠΎΡ€ΠΎΠ³ΠΎ Ρ‚ΠΈΠΏΠ° (SLC1A2 rs4354668) с Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ΠΌ рассСянного склСроза Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ², ΠΏΡ€ΠΎΠΆΠΈΠ²Π°ΡŽΡ‰ΠΈΡ… Π² Вомской области

    Get PDF
    Background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that affects people of working age and ultimately leads to disability. This disease is of polygenic origin. The role of factors related to the pathogenesis of the disease and affecting both neuroinflammation and remyelination is studied. Aims: Our goal was to investigate the association of single nucleotide polymorphisms BDNF rs6265 and SLC1A2 rs4354668 with the risk of occurrence, clinical manifestations and the course of MS.Materials and methods: The study included 302 patients with MS, 268 healthy volunteers were enrolled in a control group. The obtained blood was used for DNA extraction by standard phenol-chloroform method. The identification of allelic variants of genes SLC1A2 (rs4354668) and BDNF (rs6265) was performed by polymerase chain reaction.Results: When comparing the frequencies of genotypes and alleles of polymorphic variants of BDNF and SLC1A2 genes between the groups of MS patients and the control group, no statistically significant differences were revealed. Comparison of genotype and allele frequencies of patients depending on sex, age of onset of the disease also did not reveal statistically significant differences. The study of the association of polymorphic variant of the gene BDNF (rs6265) with clinical manifestations of the disease revealed the association of genotype CC with oculomotor and trigeminal disorders at the onset of the disease (F=7, p=0.017). The study of the polymorphic variant rs4354668 of the glutamate transporter gene SLC1A2 revealed the association of allele G with an earlier (within 5 years from the moment of debut) transition of the disease to the stage of secondary progression, despite the therapy with DMT (Ο‡2=5.940; p=0.010; OR 1.58; 95% CI 1.09βˆ’2.29). Homozygous genotype of TT (Ο‡2=6.393; p=0.041; OR 0.50; 95% CI 0.28βˆ’0.88) and allele T (Ο‡2=5.940; p=0.010; OR 0.63; 95% CI 0.44βˆ’0.92) of the polymorphism rs4354668 of the glutamate transporter gene SLC1A2 are significantly more common in the group of patients with late transition (15 years or more from the moment of debut) to the secondary progressive course.Conclusions: In our study we revealed the relationship of the studied polymorphic variants of genes with clinical signs at the onset of the disease and with the clinical manifestations of MS in patients living in the Tomsk region.ОбоснованиС. РассСянный склСроз ― Π°ΡƒΡ‚ΠΎΠΈΠΌΠΌΡƒΠ½Π½ΠΎΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ Π½Π΅Ρ€Π²Π½ΠΎΠΉ систСмы, ΠΏΠΎΡ€Π°ΠΆΠ°ΡŽΡ‰Π΅Π΅ людСй трудоспособного возраста ΠΈ приводящСС Π² ΠΊΠΎΠ½Π΅Ρ‡Π½ΠΎΠΌ ΠΈΡ‚ΠΎΠ³Π΅ ΠΊ ΠΈΠ½Π²Π°Π»ΠΈΠ΄ΠΈΠ·Π°Ρ†ΠΈΠΈ. Π’ послСдниС Π³ΠΎΠ΄Ρ‹ Π½Π°Π±Π»ΡŽΠ΄Π°Π΅Ρ‚ΡΡ рост числа Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ…, связанный ΠΊΠ°ΠΊ с истинным ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ΠΌ заболСваСмости, Ρ‚Π°ΠΊ ΠΈ с качСством диагностики.ЦСль исслСдования ― ΠΎΡ†Π΅Π½ΠΊΠ° ассоциации ΠΎΠ΄Π½ΠΎΠ½ΡƒΠΊΠ»Π΅ΠΎΡ‚ΠΈΠ΄Π½Ρ‹Ρ… ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… Π²Π°Ρ€ΠΈΠ°Π½Ρ‚ΠΎΠ² Π³Π΅Π½ΠΎΠ² BDNF rs6265 ΠΈ SLC1A2 rs4354668 с риском возникновСния, клиничСскими проявлСниями ΠΈ Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ΠΌ рассСянного склСроза.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ исслСдованиС Π±Ρ‹Π»ΠΎ Π²ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΎ 302 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π° с рассСянным склСрозом, 268 Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… Π΄ΠΎΠ±Ρ€ΠΎΠ²ΠΎΠ»ΡŒΡ†Π΅Π² составили Π³Ρ€ΡƒΠΏΠΏΡƒ контроля. ΠŸΠ°Ρ†ΠΈΠ΅Π½Ρ‚Ρ‹ Π½Π°Ρ…ΠΎΠ΄ΠΈΠ»ΠΈΡΡŒ Π½Π° Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ Π² нСврологичСской ΠΊΠ»ΠΈΠ½ΠΈΠΊΠ΅ Бибирского государствСнного мСдицинского унивСрситСта. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π°Π»Π»Π΅Π»ΡŒΠ½Ρ‹Ρ… Π²Π°Ρ€ΠΈΠ°Π½Ρ‚ΠΎΠ² Π³Π΅Π½ΠΎΠ² SLC1A2 (rs4354668) ΠΈ BDNF (rs6265) ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ€Π°Π·Π½ΠΎΠΉ Ρ†Π΅ΠΏΠ½ΠΎΠΉ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ. ΠΠΌΠΏΠ»ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΡŽ ΠΈ Π°Π½Π°Π»ΠΈΠ· Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² осущСствляли с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΏΡ€ΠΈΠ±ΠΎΡ€ΠΎΠ² StepOnePlus ΠΈ Quant Studio 5 (Applied Biosystems, БША).Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠŸΡ€ΠΈ сравнСнии частоты Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΠΎΠ² ΠΈ Π°Π»Π»Π΅Π»Π΅ΠΉ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… Π²Π°Ρ€ΠΈΠ°Π½Ρ‚ΠΎΠ² Π³Π΅Π½ΠΎΠ² BDNF ΠΈ SLC1A2 ΠΌΠ΅ΠΆΠ΄Ρƒ Π³Ρ€ΡƒΠΏΠΏΠ°ΠΌΠΈ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с рассСянным склСрозом ΠΈ Π³Ρ€ΡƒΠΏΠΏΠΎΠΉ контроля статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΡ‹Ρ… Ρ€Π°Π·Π»ΠΈΡ‡ΠΈΠΉ Π½Π΅ выявлСно. Π‘Ρ€Π°Π²Π½Π΅Π½ΠΈΠ΅ частоты Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΠΎΠ² ΠΈ Π°Π»Π»Π΅Π»Π΅ΠΉ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Π² зависимости ΠΎΡ‚ ΠΏΠΎΠ»Π°, возраста Π½Π°Ρ‡Π°Π»Π° заболСвания Ρ‚Π°ΠΊΠΆΠ΅ статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΡ‹Ρ… Ρ€Π°Π·Π»ΠΈΡ‡ΠΈΠΉ Π½Π΅ выявило. ΠŸΡ€ΠΈ исслСдовании связи ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½ΠΎΠ³ΠΎ Π²Π°Ρ€ΠΈΠ°Π½Ρ‚Π° Π³Π΅Π½Π° BDNF (rs6265) с клиничСскими проявлСниями Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π½Π°ΠΉΠ΄Π΅Π½Π° ассоциация Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΠ° Π‘Π‘ с Π³Π»Π°Π·ΠΎΠ΄Π²ΠΈΠ³Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹ΠΌΠΈ ΠΈ Ρ‚Ρ€ΠΈΠ³Π΅ΠΌΠΈΠ½Π°Π»ΡŒΠ½Ρ‹ΠΌΠΈ расстройствами Π² Π΄Π΅Π±ΡŽΡ‚Π΅ заболСвания (F=7; p=0,017). ΠŸΡ€ΠΈ исслСдовании ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½ΠΎΠ³ΠΎ Π²Π°Ρ€ΠΈΠ°Π½Ρ‚Π° rs4354668 Π³Π΅Π½Π° Π³Π»ΡƒΡ‚Π°ΠΌΠ°Ρ‚Π½ΠΎΠ³ΠΎ транспортСра SLC1A2 выявлСна ассоциация аллСля G с Π±ΠΎΠ»Π΅Π΅ Ρ€Π°Π½Π½ΠΈΠΌ (Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ 5 Π»Π΅Ρ‚ ΠΎΡ‚ ΠΌΠΎΠΌΠ΅Π½Ρ‚Π° Π΄Π΅Π±ΡŽΡ‚Π°) ΠΏΠ΅Ρ€Π΅Ρ…ΠΎΠ΄ΠΎΠΌ заболСвания Π² ΡΡ‚Π°Π΄ΠΈΡŽ Π²Ρ‚ΠΎΡ€ΠΈΡ‡Π½ΠΎΠ³ΠΎ прогрСссирования, нСсмотря Π½Π° Ρ‚Π΅Ρ€Π°ΠΏΠΈΡŽ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌΠΈ, ΠΈΠ·ΠΌΠ΅Π½ΡΡŽΡ‰ΠΈΠΌΠΈ Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ рассСянного склСроза (Ο‡2=5,940; Ρ€=0,010; OR 1,58; 95% CI 1,09βˆ’2,29). Π“ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡ‚Π½Ρ‹ΠΉ Π³Π΅Π½ΠΎΡ‚ΠΈΠΏ Π’Π’ (Ο‡2=6,393; Ρ€=0,041; OR 0,50; 95% CI 0,28βˆ’0,88) ΠΈ аллСль Π’ (Ο‡2=5,940; Ρ€=0,010; OR 0,63; 95% CI 0,44βˆ’0,92) ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° rs4354668 Π³Π΅Π½Π° Π³Π»ΡƒΡ‚Π°ΠΌΠ°Ρ‚Π½ΠΎΠ³ΠΎ транспортСра SLC1A2 статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΠΎ Ρ‡Π°Ρ‰Π΅ Π²ΡΡ‚Ρ€Π΅Ρ‡Π°ΡŽΡ‚ΡΡ Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΠΏΠΎΠ·Π΄Π½ΠΈΠΌ ΠΏΠ΅Ρ€Π΅Ρ…ΠΎΠ΄ΠΎΠΌ (Ρ‡Π΅Ρ€Π΅Π· 15 ΠΈ Π±ΠΎΠ»Π΅Π΅ Π»Π΅Ρ‚ ΠΎΡ‚ ΠΌΠΎΠΌΠ΅Π½Ρ‚Π° Π΄Π΅Π±ΡŽΡ‚Π°) Π²ΠΎ Π²Ρ‚ΠΎΡ€ΠΈΡ‡Π½ΠΎ-ΠΏΡ€ΠΎΠ³Ρ€Π΅ΡΡΠΈΡ€ΡƒΡŽΡ‰Π΅Π΅ Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π’ нашСм исслСдовании выявлСна связь ΠΈΠ·ΡƒΡ‡Π°Π΅ΠΌΡ‹Ρ… ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… Π²Π°Ρ€ΠΈΠ°Π½Ρ‚ΠΎΠ² Π³Π΅Π½ΠΎΠ² с клиничСскими ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ Π² Π΄Π΅Π±ΡŽΡ‚Π΅ заболСвания ΠΈ с ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡ‚ΡŒΡŽ тСчСния заболСвания Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ², ΠΏΡ€ΠΎΠΆΠΈΠ²Π°ΡŽΡ‰ΠΈΡ… Π½Π° Ρ‚Π΅Ρ€Ρ€ΠΈΡ‚ΠΎΡ€ΠΈΠΈ Вомской области

    Impact analysis of accidents on the traffic flow based on massive floating car data

    Get PDF
    The wide usage of GPS-equipped devices enables the mass recording of vehicle movement trajectories describing the movement behavior of the traffic participants. An important aspect of the road traffic is the impact of anomalies, like accidents, on traffic flow. Accidents are especially important as they contribute to the the aspects of safety and also influence travel time estimations. In this paper, the impact of accidents is determined based on a massive GPS trajectory and accident dataset. Due to the missing precise date of the accidents in the data set used, first, the date of the accident is estimated based on the speed profile at the accident time. Further, the temporal impact of the accident is estimated using the speed profile of the whole day. The approach is applied in an experiment on a one month subset of the datasets. The results show that more than 72% of the accident dates are identified and the impact on the temporal dimension is approximated. Moreover, it can be seen that accidents during the rush hours and on high frequency road types (e.g. motorways, trunks or primaries) have an increasing effect on the impact duration on the traffic flow

    Early carboniferous brachiopod faunas from the Baoshan block, west Yunnan, southwest China

    Full text link
    38 brachiopod species in 27 genera and subgenera are described from the Yudong Formation in the Shidian-Baoshan area, west Yunnan, southwest China. New taxa include two new subgenera: Unispirifer (Septimispirifer) and Brachythyrina (Longathyrina), and seven new species: Eomarginifera yunnanensis, Marginatia cylindrica, Unispirifer (Unispirifer) xiangshanensis, Unispirifer (Septimispirifer) wafangjieensis, Brachythyrina (Brachythyrina) transversa, Brachythyrina (Longathyrina) baoshanensis, and Girtyella wafangjieensis. Based on the described material and constraints from associated coral and conodont faunas, the age of the brachiopod fauna from the Yudon Formation is considered late Tournaisian (Early Carboniferous), with a possibility extending into earlyViseacutean.<br /

    A Hierarchical Taxonomy of Psychopathology Can Transform Mental Health Research

    Get PDF
    For more than a century, research on psychopathology has focused on categorical diagnoses. Although this work has produced major discoveries, growing evidence points to the superiority of a dimensional approach to the science of mental illness. Here we outline one such dimensional systemβ€”the Hierarchical Taxonomy of Psychopathology (HiTOP)β€”that is based on empirical patterns of co-occurrence among psychological symptoms. We highlight key ways in which this framework can advance mental-health research, and we provide some heuristics for using HiTOP to test theories of psychopathology. We then review emerging evidence that supports the value of a hierarchical, dimensional model of mental illness across diverse research areas in psychological science. These new data suggest that the HiTOP system has the potential to accelerate and improve research on mental-health problems as well as efforts to more effectively assess, prevent, and treat mental illness.FSW – Publicaties zonder aanstelling Universiteit Leide
    • …
    corecore