3,108 research outputs found
Computational Astrocyence: Astrocytes encode inhibitory activity into the frequency and spatial extent of their calcium elevations
Deciphering the complex interactions between neurotransmission and astrocytic
elevations is a target promising a comprehensive understanding of
brain function. While the astrocytic response to excitatory synaptic activity
has been extensively studied, how inhibitory activity results to intracellular
waves remains elusive. In this study, we developed a compartmental
astrocytic model that exhibits distinct levels of responsiveness to inhibitory
activity. Our model suggested that the astrocytic coverage of inhibitory
terminals defines the spatial and temporal scale of their elevations.
Understanding the interplay between the synaptic pathways and the astrocytic
responses will help us identify how astrocytes work independently and
cooperatively with neurons, in health and disease.Comment: 4 pages, 3 figures, IEEE-EMBS International Conference on Biomedical
and Health Informatics (BHI '19
The Golden Horde Nomads and the Surrounding World: a mutual perception paradigm
A discourse analysis of the texts (narratives) by medieval European (Plano Carpini, Guillaume de Rubrouck, Riccoldo da Monte di Croce) and Eastern (Al-Omari, Ibn-Battuta) authors addressing the nomads of the Golden Horde has allowed the author of the paper to draw a number of conclusions regarding the mutual perception of nomads, who represented the main part of the Golden Horde society, by the European (Catholic) and Eastern (Muslim) worlds. In particular, from the viewpoint of European narrators, this was a world posing a potential danger to Christian Europe. From the viewpoint of Eastern (Muslim) authors, this world did not deserve any serious attention. As for the Golden Horde nomads themselves, due to their mentality accounted for by their way of life and ideology, they perceived the world around them primarily as an object of mercantile exploitation
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Molecular Cloning of a Bovine Immunoglobulin Lambda Chain cDNA
A cDNA library of the bovine mammary gland constructed in pBR322 was screened by mRNA hybrid-selected translation and by differential hybridization. Several immunoglobulin (Ig) λ light-chain clones were identified and sequenced. Nucleotide sequence comparison of bovine and human Ig λ chains showed a high degree of homology for constant regions and for J regions. The amino acid (aa) sequence encoded by the constant region of the bovine Ig λ chain cDNA contains 107 aa with differences at 24 aa positions from the human Ig A chain. Three complementarity-determining regions (CDR1,2,3) characteristic of the variable region of bovine Ig λ chain cDNA can be distinguished. The bovine and human sequences display good homology in the framework region 3 (FR3) but only patches of homology throughout the FR2 region. The 5′ end of the bovine Ig λ chain cDNA fragment of clone 1-14E contains five stop codons: two in CDR1, one in FR1 and two in the hydrophobic prepeptide region. These data suggest that the Igλ mRNA of clone 1-14E is transcribed from the Vλ pseudogene
Theoretical description of the decays
We calculate the invariant and helicity amplitudes for the transitions
where the
are -type ground and excited states with
quantum numbers . The calculations are
performed in the framework of a covariant confined quark model previously
developed by us. We find that the values of the helicity amplitudes for the
and the are
suppressed compared with those for the ground state
and the excited state . This analysis is
important for the identification of the hidden charm pentaquark states
and which were discovered in the decay chain
because the cascade decay chain
involves the same
final state.Comment: 15 pages, 4 figures. Minor corrections don
Riemann-Hilbert problem, integrability and reductions
The present paper is dedicated to integrable models with Mikhailov reduction
groups Their Lax representation allows us to prove,
that their solution is equivalent to solving Riemann-Hilbert problems, whose
contours depend on the realization of the -action on the spectral
parameter. Two new examples of Nonlinear Evolution Equations (NLEE) with
symmetries are presented.Comment: 19 pages, 3 figures, Dedicated to Darryl Holm's 70th birthda
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